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Protein

Aquaporin Z

Gene

aqpZ

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transport of water across the membrane. Possibly involved in the adaptation to variation in intravacuolar pH or osmolarity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei20Involved in tetramerization or stability of the tetramerBy similarity1
Sitei43Selectivity filterBy similarity1
Sitei172Selectivity filterBy similarity1
Sitei181Selectivity filterBy similarity1
Sitei187Selectivity filterBy similarity1

GO - Molecular functioni

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin Z
Gene namesi
Name:aqpZ
Ordered Locus Names:BMEI0070
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

Q9L772:

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 29Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini30 – 33PeriplasmicSequence analysis4
Transmembranei34 – 56Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini57 – 80CytoplasmicSequence analysisAdd BLAST24
Transmembranei81 – 103Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini104 – 126PeriplasmicSequence analysisAdd BLAST23
Transmembranei127 – 149Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini150 – 153CytoplasmicSequence analysis4
Transmembranei154 – 176Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini177 – 202PeriplasmicSequence analysisAdd BLAST26
Transmembranei203 – 225Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini226 – 228CytoplasmicSequence analysis3

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639851 – 228Aquaporin ZAdd BLAST228

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi224914.BAWG_0126.

Structurei

3D structure databases

ProteinModelPortaliQ9L772.
SMRiQ9L772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi63 – 65NPA 13
Motifi184 – 186NPA 23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi92 – 97Poly-Ala6

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D8C. Bacteria.
COG0580. LUCA.
HOGENOMiHOG000288286.
KOiK06188.
OMAiELFGTFW.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
HAMAPiMF_01146. Aquaporin_Z. 1 hit.
InterProiView protein in InterPro
IPR023271. Aquaporin-like.
IPR034294. Aquaporin_transptr.
IPR023743. Aquaporin_Z.
IPR000425. MIP.
IPR022357. MIP_CS.
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiView protein in Pfam
PF00230. MIP. 1 hit.
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiView protein in PROSITE
PS00221. MIP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9L772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNKLSAEFF GTFWLVFGGC GSAILAAAFP ELGIGFLGVA LAFGLTVLTM
60 70 80 90 100
AYAVGGISGG HFNPAVSLGL TVAGRLPAKD LIPYWVAQVL GAIAAAAILY
110 120 130 140 150
VIASGKDGFS AGGLASNGYG ELSPGGYSMM AGLLIEIILT AFFIIIILGS
160 170 180 190 200
TSSLAPAGFA PIAIGFGLTL IHLVSIPVTN TWVNPARSTG VALFADTAAL
210 220
SQLWLFWVAP LVGAVIGAII WKGLLGRD
Length:228
Mass (Da):23,189
Last modified:October 1, 2000 - v1
Checksum:i64282C39E4DD4109
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226624 Genomic DNA. Translation: AAF36396.1.
AE008917 Genomic DNA. Translation: AAL51252.1.
PIRiAI3260.
RefSeqiWP_004684491.1. NZ_GG703778.1.

Genome annotation databases

EnsemblBacteriaiAAL51252; AAL51252; BMEI0070.
GeneIDi29594900.
KEGGibme:BMEI0070.
bmel:DK63_1364.
PATRICifig|224914.52.peg.1440.

Similar proteinsi

Entry informationi

Entry nameiAQPZ_BRUME
AccessioniPrimary (citable) accession number: Q9L772
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 1, 2000
Last modified: June 7, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families