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Protein

Histidine kinase

Gene

hstK

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphorelay sensor kinase activity Source: InterPro
  3. protein serine/threonine kinase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine kinaseSAAS annotation (EC:2.7.13.3SAAS annotation)
Gene namesi
Name:hstKImported
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)Imported
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi103690.alr2258.

Structurei

3D structure databases

ProteinModelPortaliQ9L708.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains histidine kinase domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG0642.
HOGENOMiHOG000263148.
OMAiPLIAFTM.
OrthoDBiEOG6HTNS7.

Family and domain databases

Gene3Di3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003661. EnvZ-like_dim/P.
IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003594. HATPase_C.
IPR011009. Kinase-like_dom.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9L708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITLPNYQII ELIGEGVKTN VYHAISIPDS KLVVIKILKT EYPELKDIAA
60 70 80 90 100
LKHEYELIKN LDIPGVVKAH GFEKYNNCFA LVLEEFDGTS LHKVIQEKKI
110 120 130 140 150
GLLDFCKIGI QITQALGELH RKYIIHKDIK PQNIIVNLET HQVKIIDFSI
160 170 180 190 200
SSLLFQEKAK LNNPNLLEGT IAYMSPEQTG RMNRSIDYRT DFYSLGVTFY
210 220 230 240 250
EMLTGQLPFI VTDPMELVHC HIAKQPISIN QLIPEIPEVV SEIIMKLLSK
260 270 280 290 300
TAEERYQSAL GIKADLEKCL NQLVAVDSIT TFPIGQHDQS SQLQIPEKLY
310 320 330 340 350
GREAEIDILM AAFENVNQGH KELILVAGYS GIGKSALVNE IHKPVIKNRG
360 370 380 390 400
YFIAGKFEQF QRNIPYASLI QAFQELMQQL LTESGQQLAN WRERILAALV
410 420 430 440 450
PNAQIIIDVI PELELIIGKQ PEVPQLGSAE AQNRFNLVMQ KFINVFAQKE
460 470 480 490 500
HPLVVFLDDL QWADLASLKL IQLLAINSDI QYLFLIGAYR DNEVDSSHHL
510 520 530 540 550
MLILQEIEKN RTPINIIYCQ NLKITDVCQL VGDTLKSGLE DSKELAKLIF
560 570 580 590 600
HKTGGNPFFI NQLLKFIHQE NLLVFNFITG QWQWYIQYIQ MLDITDNVVD
610 620 630 640 650
LMIGKIQKLK DNTQNIIKIA ACIGNRFNLN TLSCINEKSH NATALDIWEA
660 670 680 690 700
LQAGLIIPLS DNYKLPQLLD DVDIFVIDYK FLHDRVQQAA YALIPDEHKK
710 720 730 740 750
EIHLNIGRLL LKNIDKSLLE EKIFDIANQL NMGAGLITAP EERYKLAALN
760 770 780 790 800
LMAGRKAKDS TAYESAVSFL KQGLNLLDID CWQKHYELTL DLHVETVESA
810 820 830 840 850
YLNTNFEEAE PLFATVIANS KNILDAVKVY EKKIQFYVGQ NRMREALDLD
860 870 880 890 900
LQVLGMLGVS LSQTPPAELK IEELINLPEM MDPSKLAAMR ILMTAMPPAY
910 920 930 940 950
LADPALLPLI AFTMIDLCLQ YGNSSFAAYA YGFYGLILCG PLNNIESGYR
960 970 980 990 1000
FGKLSLQILN QFNAKEIKSK VYALFNIFVR HWKEHIQTTI EPLQEGVQSG
1010 1020 1030 1040 1050
LDTGDIEYVG YNGLLVCWHP FWSGENLETV EQRLDKYINL AQRIQQEHFT
1060 1070 1080 1090 1100
VCLLILKQLL TELKQGLKNE VYLDGDDFNN SIMQRMAGNI TAIFYAYLAK
1110 1120 1130 1140 1150
SILSYFFKDY SQAVKNAELA QQYEVAVGGT FYLIEYKFYY SLALLALCLN
1160 1170 1180 1190 1200
LTSDADITSA LEKVSENQQQ LKEWADHAPI NNQHKYELVE AEKARVLGQV
1210 1220 1230 1240 1250
LIAMEYYECA IQGAHKFGYI HEEALAYECA AEFYFSLGRN EFACLYITKA
1260 1270 1280 1290 1300
HYGYRHWGAS AKVRNLESKY PELTAKISSQ YPADFTNTNI TTSTASEKSS
1310 1320 1330 1340 1350
GLDLISVIKA SQTLSEVILL DNLLEKLMTI VIENAGAQTG ILLLEKAGNL
1360 1370 1380 1390 1400
LIEAKASVDK DDVTVGQSIP FEDSQQLPIS VINFVRRTRK DVVLSDASNE
1410 1420 1430 1440 1450
GSFILDPYII KQDIKSIICT SILNQGKLIG ILYLENNLIV GAFTADRIQI
1460 1470 1480 1490 1500
LKLLSTQAAI SLENARLYAN LEEKIEERTR ELNENNLRLR QTLHELKLTQ
1510 1520 1530 1540 1550
TQLIQTEKMS SLGQMVAGIA HEINNPVSFI HGNLSHIDNY ANDLLTLIDI
1560 1570 1580 1590 1600
YRSIYPEATP EIEEFLENID VDFIKEDMPK TLSSMKIGTQ RIREIVLTLR
1610 1620 1630 1640 1650
NFSRLDEADM KPVDIHEGIE STLLILQSRL QAKPGKPAIE IIKNYAELPK
1660 1670 1680 1690 1700
VECYTGQLNQ VFMNILNNAI DSLEKLNREH NLEEIKTDAS AIAIRTEVVN
1710 1720 1730 1740 1750
PDLVAISIKD NGLGMSDSVR QRIFDPFFTT KPIGQGTGLG LSISYQIVVD
1760 1770
KHRGSIECIS TPGQGAEFII QIPCRQK
Length:1,777
Mass (Da):200,912
Last modified:October 1, 2000 - v1
Checksum:i81D5684741F76A24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230361 Genomic DNA. Translation: AAF44653.1.
BA000019 Genomic DNA. Translation: BAB73957.1.
PIRiAC2088.
RefSeqiNP_486298.1. NC_003272.1.
WP_010996415.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB73957; BAB73957; BAB73957.
GeneIDi1105855.
KEGGiana:alr2258.
PATRICi22774684. VBINosSp37423_2809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF230361 Genomic DNA. Translation: AAF44653.1.
BA000019 Genomic DNA. Translation: BAB73957.1.
PIRiAC2088.
RefSeqiNP_486298.1. NC_003272.1.
WP_010996415.1. NC_003272.1.

3D structure databases

ProteinModelPortaliQ9L708.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.alr2258.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB73957; BAB73957; BAB73957.
GeneIDi1105855.
KEGGiana:alr2258.
PATRICi22774684. VBINosSp37423_2809.

Phylogenomic databases

eggNOGiCOG0642.
HOGENOMiHOG000263148.
OMAiPLIAFTM.
OrthoDBiEOG6HTNS7.

Family and domain databases

Gene3Di3.30.450.40. 1 hit.
3.30.565.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003661. EnvZ-like_dim/P.
IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003594. HATPase_C.
IPR011009. Kinase-like_dom.
IPR027417. P-loop_NTPase.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
PfamiPF01590. GAF. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00065. GAF. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 2 hits.
SSF52540. SSF52540. 1 hit.
SSF55781. SSF55781. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "HstK, a cyanobacterial protein with both a serine/threonine kinase domain and a histidine kinase domain: implication for the mechanism of signal transduction."
    Phalip V., Li J.H., Zhang C.C.
    Biochem. J. 360:639-644(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120Imported and PCC 7120 / UTEX 2576Imported.

Entry informationi

Entry nameiQ9L708_NOSS1
AccessioniPrimary (citable) accession number: Q9L708
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: March 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.