Q9L6Q8 (WECF_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-alpha-L-fucosyltransferase
EC=2.4.1.-

Alternative name(s):
TDP-Fuc4NAc:lipid II Fuc4NAc transferase
Short name=Fuc4NAc transferase

Gene names

Name:	wecF
Synonyms:	rffT
Ordered Locus Names:	STM3927
ORF Names:	STMD1.63

Organism

Salmonella typhimurium

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis By similarity. HAMAP MF_01002
Catalytic activity	TDP-Fuc4NAc + Und-PP-GlcNAc-ManNAcA = TDP + Und-PP-GlcNAc-ManNAcA-Fuc4NAc. HAMAP MF_01002
Pathway	Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. HAMAP MF_01002
Subcellular location	Cell inner membrane; Peripheral membrane protein Potential HAMAP MF_01002.
Sequence similarities	Belongs to the glycosyltransferase 56 family.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	enterobacterial common antigen biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	Gram-negative-bacterium-type cell wall Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fucosyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	4-alpha-L-fucosyltransferase HAMAP MF_01002		PRO_0000216188

Sequences

	Sequence		Length	Mass (Da)
	Q9L6Q8 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: C3F3DB29DC3E5595	FASTA	359	40,543
	10 20 30 40 50 60 MTVLIHVLGS DIPHHNHTVL RFFNDTLAAT SEHAREFMVA GEDNGFTESC PALSLRFYGS 70 80 90 100 110 120 KKALAQAVIA KAKANRRQRF FFHGQFNTSL WLALLSGGIK PAQFYWHIWG ADLYEVSHGL 130 140 150 160 170 180 KFRLFYPLRR IAQGRVGGVF ATRGDLSYFA RQHPDVRGEL LYFPTRMDPS LNAMAKERQR 190 200 210 220 230 240 AGKLTILVGN SGDRSNQHIA ALRAVYQQFG DTVNVVVPMG YPANNQDYID EVRQAGLALF 250 260 270 280 290 300 SAENLQILSE KMEFDAYLAL LRQCDLGYFI FARQQGIGTL CLLIQADIPC VLNRDNPFWQ 310 320 330 340 350 DMAEQHLPVL FTTDDLNEQV VREAQRQLAS VDKSGITFFS PNYLQPWHNA LRIAAGEAE

References

[1]

"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF233324 Genomic DNA. Translation: AAF33460.1. AE006468 Genomic DNA. Translation: AAL22776.1.
RefSeq	NP_462817.1. NC_003197.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT56. Glycosyltransferase Family 56.
Proteomic databases
PRIDE	Q9L6Q8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1255453.
GenomeReviews	Gene locus STM3927 in contig AE006468_GR.
KEGG	stm:STM3927.
NMPDR	fig|99287.1.peg.3791.
PATRIC	32386717. VBISalEnt20916_4148.
Phylogenomic databases
HOGENOM	HBG296660.
OMA	IPHHNQT.
ProtClustDB	PRK02797.
Enzyme and pathway databases
BioCyc	STYP99287:STM3927-MONOMER.
Family and domain databases
HAMAP	MF_01002. WecF_RffT. [Tree]
InterPro	IPR009993. 4-alpha-FUT. [Graphical view]
KO	K12582.
Pfam	PF07429. Fuc4NAc_transf. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

WECF_SALTY

Accession

Primary (citable) accession number: Q9L6Q8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program