Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uroporphyrinogen-III synthase

Gene

hemD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi

GO - Molecular functioni

  1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciSENT99287:GCTI-3966-MONOMER.
UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:hemD
Ordered Locus Names:STM3937
ORF Names:STMD1.54
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Uroporphyrinogen-III synthasePRO_0000135246Add
BLAST

Proteomic databases

PaxDbiQ9L6Q3.
PRIDEiQ9L6Q3.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi99287.STM3937.

Structurei

3D structure databases

ProteinModelPortaliQ9L6Q3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1587.
HOGENOMiHOG000247993.
KOiK01719.
OMAiYCECYQR.
OrthoDBiEOG6RZB2F.
PhylomeDBiQ9L6Q3.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9L6Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILITRPSP AGEALVSRLR ALGQVAWSFP LIEFVAGREL PTLADRLATL
60 70 80 90 100
TENDLVFALS QHAVAFAHAQ LQRDGRNWPV APRYFAIGRT TALALHTVSG
110 120 130 140 150
FDIRYPLDRE ISEALLQLPE LQNIAGKRAL ILRGNGGREL LGETLTARGA
160 170 180 190 200
EVSFCECYQR CAKHYDGAEE AMRWHTRGVT TLVVTSGEML QRLWSLTPQW
210 220 230 240
YREHWLLRCR LLVVSERLAH LARELGWQDI KVADNADNDA LLRALQ
Length:246
Mass (Da):27,662
Last modified:October 1, 2000 - v1
Checksum:iAB28397040404C22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233324 Genomic DNA. Translation: AAF33454.1.
AE006468 Genomic DNA. Translation: AAL22782.1.
RefSeqiNP_462823.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22782; AAL22782; STM3937.
GeneIDi1255463.
KEGGistm:STM3937.
PATRICi32386737. VBISalEnt20916_4154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233324 Genomic DNA. Translation: AAF33454.1.
AE006468 Genomic DNA. Translation: AAL22782.1.
RefSeqiNP_462823.1. NC_003197.1.

3D structure databases

ProteinModelPortaliQ9L6Q3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM3937.

Proteomic databases

PaxDbiQ9L6Q3.
PRIDEiQ9L6Q3.

Protocols and materials databases

DNASUi1255463.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22782; AAL22782; STM3937.
GeneIDi1255463.
KEGGistm:STM3937.
PATRICi32386737. VBISalEnt20916_4154.

Phylogenomic databases

eggNOGiCOG1587.
HOGENOMiHOG000247993.
KOiK01719.
OMAiYCECYQR.
OrthoDBiEOG6RZB2F.
PhylomeDBiQ9L6Q3.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00320.
BioCyciSENT99287:GCTI-3966-MONOMER.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiHEM4_SALTY
AccessioniPrimary (citable) accession number: Q9L6Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.