Q9L6Q3 (HEM4_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen-III synthase
Short name=UROS
EC=4.2.1.75

Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase

Gene names

Name:	hemD
Ordered Locus Names:	STM3937
ORF Names:	STMD1.54

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]

Taxonomic identifier

99287 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.
Catalytic activity	Hydroxymethylbilane = uroporphyrinogen III + H2O.
Pathway	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the uroporphyrinogen-III synthase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	uroporphyrinogen-III synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Uroporphyrinogen-III synthase		PRO_0000135246

Sequences

	Sequence		Length	Mass (Da)
	Q9L6Q3 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: AB28397040404C22	FASTA	246	27,662
	10 20 30 40 50 60 MSILITRPSP AGEALVSRLR ALGQVAWSFP LIEFVAGREL PTLADRLATL TENDLVFALS 70 80 90 100 110 120 QHAVAFAHAQ LQRDGRNWPV APRYFAIGRT TALALHTVSG FDIRYPLDRE ISEALLQLPE 130 140 150 160 170 180 LQNIAGKRAL ILRGNGGREL LGETLTARGA EVSFCECYQR CAKHYDGAEE AMRWHTRGVT 190 200 210 220 230 240 TLVVTSGEML QRLWSLTPQW YREHWLLRCR LLVVSERLAH LARELGWQDI KVADNADNDA LLRALQ

References

[1]

"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF233324 Genomic DNA. Translation: AAF33454.1. AE006468 Genomic DNA. Translation: AAL22782.1.
RefSeq	NP_462823.1. NC_003197.1.
3D structure databases
ProteinModelPortal	Q9L6Q3.
ModBase	Search...
Protein-protein interaction databases
STRING	99287.STM3937.
Proteomic databases
PaxDb	Q9L6Q3.
PRIDE	Q9L6Q3.
Protocols and materials databases
DNASU	1255463.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL22782; AAL22782; STM3937.
GeneID	1255463.
KEGG	stm:STM3937.
PATRIC	32386737. VBISalEnt20916_4154.
Phylogenomic databases
eggNOG	COG1587.
HOGENOM	HOG000247993.
KO	K01719.
OMA	YCECYQR.
ProtClustDB	PRK05928.
Enzyme and pathway databases
BioCyc	SENT99287:GCTI-3966-MONOMER.
UniPathway	UPA00251; UER00320.
Family and domain databases
InterPro	IPR003754. 4pyrrol_synth_uPrphyn_synth. [Graphical view]
Pfam	PF02602. HEM4. 1 hit. [Graphical view]
SUPFAM	SSF69618. HEM4_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HEM4_SALTY

Accession

Primary (citable) accession number: Q9L6Q3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	October 1, 2000
Last modified:	May 29, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program