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Q9L6Q3 (HEM4_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen-III synthase

Short name=UROS
EC=4.2.1.75
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene names
Name:hemD
Ordered Locus Names:STM3937
ORF Names:STMD1.54
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.

Catalytic activity

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the uroporphyrinogen-III synthase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionuroporphyrinogen-III synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Uroporphyrinogen-III synthase
PRO_0000135246

Sequences

Sequence LengthMass (Da)Tools
Q9L6Q3 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: AB28397040404C22

FASTA24627,662
        10         20         30         40         50         60 
MSILITRPSP AGEALVSRLR ALGQVAWSFP LIEFVAGREL PTLADRLATL TENDLVFALS 

        70         80         90        100        110        120 
QHAVAFAHAQ LQRDGRNWPV APRYFAIGRT TALALHTVSG FDIRYPLDRE ISEALLQLPE 

       130        140        150        160        170        180 
LQNIAGKRAL ILRGNGGREL LGETLTARGA EVSFCECYQR CAKHYDGAEE AMRWHTRGVT 

       190        200        210        220        230        240 
TLVVTSGEML QRLWSLTPQW YREHWLLRCR LLVVSERLAH LARELGWQDI KVADNADNDA 


LLRALQ 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF233324 Genomic DNA. Translation: AAF33454.1.
AE006468 Genomic DNA. Translation: AAL22782.1.
RefSeqNP_462823.1. NC_003197.1.

3D structure databases

ProteinModelPortalQ9L6Q3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM3937.

Proteomic databases

PaxDbQ9L6Q3.
PRIDEQ9L6Q3.

Protocols and materials databases

DNASU1255463.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL22782; AAL22782; STM3937.
GeneID1255463.
KEGGstm:STM3937.
PATRIC32386737. VBISalEnt20916_4154.

Phylogenomic databases

eggNOGCOG1587.
HOGENOMHOG000247993.
KOK01719.
OMAYCECYQR.
OrthoDBEOG6RZB2F.
PhylomeDBQ9L6Q3.

Enzyme and pathway databases

BioCycSENT99287:GCTI-3966-MONOMER.
UniPathwayUPA00251; UER00320.

Family and domain databases

InterProIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMSSF69618. SSF69618. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEM4_SALTY
AccessionPrimary (citable) accession number: Q9L6Q3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways