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Q9L6Q3

- HEM4_SALTY

UniProt

Q9L6Q3 - HEM4_SALTY

Protein

Uroporphyrinogen-III synthase

Gene

hemD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

    Catalytic activityi

    Hydroxymethylbilane = uroporphyrinogen III + H2O.

    Pathwayi

    GO - Molecular functioni

    1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-3966-MONOMER.
    UniPathwayiUPA00251; UER00320.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen-III synthase (EC:4.2.1.75)
    Short name:
    UROS
    Alternative name(s):
    Hydroxymethylbilane hydrolyase [cyclizing]
    Uroporphyrinogen-III cosynthase
    Gene namesi
    Name:hemD
    Ordered Locus Names:STM3937
    ORF Names:STMD1.54
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Uroporphyrinogen-III synthasePRO_0000135246Add
    BLAST

    Proteomic databases

    PaxDbiQ9L6Q3.
    PRIDEiQ9L6Q3.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi99287.STM3937.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9L6Q3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1587.
    HOGENOMiHOG000247993.
    KOiK01719.
    OMAiYCECYQR.
    OrthoDBiEOG6RZB2F.
    PhylomeDBiQ9L6Q3.

    Family and domain databases

    InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view]
    PfamiPF02602. HEM4. 1 hit.
    [Graphical view]
    SUPFAMiSSF69618. SSF69618. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9L6Q3-1 [UniParc]FASTAAdd to Basket

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    MSILITRPSP AGEALVSRLR ALGQVAWSFP LIEFVAGREL PTLADRLATL    50
    TENDLVFALS QHAVAFAHAQ LQRDGRNWPV APRYFAIGRT TALALHTVSG 100
    FDIRYPLDRE ISEALLQLPE LQNIAGKRAL ILRGNGGREL LGETLTARGA 150
    EVSFCECYQR CAKHYDGAEE AMRWHTRGVT TLVVTSGEML QRLWSLTPQW 200
    YREHWLLRCR LLVVSERLAH LARELGWQDI KVADNADNDA LLRALQ 246
    Length:246
    Mass (Da):27,662
    Last modified:October 1, 2000 - v1
    Checksum:iAB28397040404C22
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF233324 Genomic DNA. Translation: AAF33454.1.
    AE006468 Genomic DNA. Translation: AAL22782.1.
    RefSeqiNP_462823.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL22782; AAL22782; STM3937.
    GeneIDi1255463.
    KEGGistm:STM3937.
    PATRICi32386737. VBISalEnt20916_4154.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF233324 Genomic DNA. Translation: AAF33454.1 .
    AE006468 Genomic DNA. Translation: AAL22782.1 .
    RefSeqi NP_462823.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali Q9L6Q3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM3937.

    Proteomic databases

    PaxDbi Q9L6Q3.
    PRIDEi Q9L6Q3.

    Protocols and materials databases

    DNASUi 1255463.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL22782 ; AAL22782 ; STM3937 .
    GeneIDi 1255463.
    KEGGi stm:STM3937.
    PATRICi 32386737. VBISalEnt20916_4154.

    Phylogenomic databases

    eggNOGi COG1587.
    HOGENOMi HOG000247993.
    KOi K01719.
    OMAi YCECYQR.
    OrthoDBi EOG6RZB2F.
    PhylomeDBi Q9L6Q3.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00320 .
    BioCyci SENT99287:GCTI-3966-MONOMER.

    Family and domain databases

    InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view ]
    Pfami PF02602. HEM4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69618. SSF69618. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiHEM4_SALTY
    AccessioniPrimary (citable) accession number: Q9L6Q3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3