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Q9L6I1

- HISX_THIRO

UniProt

Q9L6I1 - HISX_THIRO

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Thiocapsa roseopersicina
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei31 – 311SubstrateBy similarity
    Metal bindingi53 – 531ZincBy similarity
    Binding sitei53 – 531SubstrateBy similarity
    Metal bindingi56 – 561ZincBy similarity
    Binding sitei56 – 561SubstrateBy similarity
    Active sitei121 – 1211Proton acceptorBy similarity
    Active sitei122 – 1221Proton acceptorBy similarity
    Binding sitei122 – 1221SubstrateBy similarity
    Metal bindingi155 – 1551ZincBy similarity
    Binding sitei155 – 1551SubstrateBy similarity
    Binding sitei209 – 2091SubstrateBy similarity
    Metal bindingi214 – 2141ZincBy similarity
    Binding sitei214 – 2141SubstrateBy similarity

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenase (EC:1.1.1.23)
    Short name:
    HDH
    Gene namesi
    Name:hisD
    OrganismiThiocapsa roseopersicina
    Taxonomic identifieri1058 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeThiocapsa

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 233›233Histidinol dehydrogenasePRO_0000135873Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9L6I1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.Curated

    Family and domain databases

    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9L6I1-1 [UniParc]FASTAAdd to Basket

    « Hide

    DKIVGPGNIY VATAKRAVFG QVGIDMVAGP SEILVVCDGA TDPDWIAMDL    50
    FSQAEHDEDA QSILLSWDAD FLDRVAASIE RLLPSMERET IIATALRGRG 100
    AMILARDLDD AIAVANRIAP EHLELSVEDP QAIVGRIRHA GAIFMGRYTA 150
    EAIGDYCAGP NHVLPTSRTA RFSSPLGVYD FQKRSSLIMA SAAGAAQLAK 200
    TASVLARGEG LTAHARSAEY RGAVEPAAEP GLS 233
    Length:233
    Mass (Da):24,671
    Last modified:October 1, 2000 - v1
    Checksum:iEDF15B51B24D45F0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF235018 Genomic DNA. Translation: AAF44661.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF235018 Genomic DNA. Translation: AAF44661.1 .

    3D structure databases

    ProteinModelPortali Q9L6I1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .

    Family and domain databases

    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes for putative enzymes of histidine biosynthesis from the phototrophic sulfur bacterium Thiocapsa roseopersicina."
      Milles J., Kappler U., Truper H.G., Dahl C.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiHISX_THIRO
    AccessioniPrimary (citable) accession number: Q9L6I1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3