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Q9L6I1

- HISX_THIRO

UniProt

Q9L6I1 - HISX_THIRO

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Thiocapsa roseopersicina
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311SubstrateBy similarity
Metal bindingi53 – 531ZincBy similarity
Binding sitei53 – 531SubstrateBy similarity
Metal bindingi56 – 561ZincBy similarity
Binding sitei56 – 561SubstrateBy similarity
Active sitei121 – 1211Proton acceptorBy similarity
Active sitei122 – 1221Proton acceptorBy similarity
Binding sitei122 – 1221SubstrateBy similarity
Metal bindingi155 – 1551ZincBy similarity
Binding sitei155 – 1551SubstrateBy similarity
Binding sitei209 – 2091SubstrateBy similarity
Metal bindingi214 – 2141ZincBy similarity
Binding sitei214 – 2141SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
OrganismiThiocapsa roseopersicina
Taxonomic identifieri1058 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeThiocapsa

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 233›233Histidinol dehydrogenasePRO_0000135873Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9L6I1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Family and domain databases

InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9L6I1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
DKIVGPGNIY VATAKRAVFG QVGIDMVAGP SEILVVCDGA TDPDWIAMDL
60 70 80 90 100
FSQAEHDEDA QSILLSWDAD FLDRVAASIE RLLPSMERET IIATALRGRG
110 120 130 140 150
AMILARDLDD AIAVANRIAP EHLELSVEDP QAIVGRIRHA GAIFMGRYTA
160 170 180 190 200
EAIGDYCAGP NHVLPTSRTA RFSSPLGVYD FQKRSSLIMA SAAGAAQLAK
210 220 230
TASVLARGEG LTAHARSAEY RGAVEPAAEP GLS
Length:233
Mass (Da):24,671
Last modified:October 1, 2000 - v1
Checksum:iEDF15B51B24D45F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF235018 Genomic DNA. Translation: AAF44661.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF235018 Genomic DNA. Translation: AAF44661.1 .

3D structure databases

ProteinModelPortali Q9L6I1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genes for putative enzymes of histidine biosynthesis from the phototrophic sulfur bacterium Thiocapsa roseopersicina."
    Milles J., Kappler U., Truper H.G., Dahl C.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHISX_THIRO
AccessioniPrimary (citable) accession number: Q9L6I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3