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Q9L6B8

- PUR1_PASMU

UniProt

Q9L6B8 - PUR1_PASMU

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Protein

Amidophosphoribosyltransferase

Gene
purF, PM0701
Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O.

Cofactori

Binds 1 magnesium ion per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21For GATase activity
Metal bindingi367 – 3671Magnesium By similarity
Metal bindingi368 – 3681Magnesium By similarity

GO - Molecular functioni

  1. amidophosphoribosyltransferase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-KW
  3. nucleoside metabolic process Source: InterPro
  4. purine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciPMUL272843:GC8W-726-MONOMER.
UniPathwayiUPA00074; UER00124.

Protein family/group databases

MEROPSiC44.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Amidophosphoribosyltransferase (EC:2.4.2.14)
Short name:
ATase
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase
Short name:
GPATase
Gene namesi
Name:purF
Ordered Locus Names:PM0701
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
ProteomesiUP000000809: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 504503AmidophosphoribosyltransferasePRO_0000139640Add
BLAST

Proteomic databases

PRIDEiQ9L6B8.

Interactioni

Protein-protein interaction databases

STRINGi272843.PM0701.

Structurei

3D structure databases

ProteinModelPortaliQ9L6B8.
SMRiQ9L6B8. Positions 2-477.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 235234Glutamine amidotransferase type-2Add
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG0034.
HOGENOMiHOG000033687.
KOiK00764.
OMAiAARVHMG.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
InterProiIPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00310. GATase_2. 2 hits.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFiPIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMiSSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01134. purF. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9L6B8-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGIVSQ SPVNQSIYDA LTLLQHRGQD AAGIVTVDDE NRFRLRKANG    50
LVSDVFEQVH MLRLQGNAGI GHVRYPTAGS SSVSEAQPFY VNSPYGLTLV 100
HNGNLTNSSE LKEKLFRRAR RHVNTNSDSE LLLNILANHL DHFEKYQLDP 150
QDVFSAVKQT HQDIRGAYAC IAMIIGHGMV AFRDPNGIRP LVLGKREENG 200
KTEYMFASES IALDTVGFEF VRDVQPGEAI YVTFEGEMYA QQCADKPTLT 250
PCIFEYVYFA RPDSCIDGVS VYAARVHMGQ RLGEKIAREW ADVDDIDVVI 300
PVPETSNDIA LRIARVLNKP YRQGFVKNRY VGRTFIMPGQ ALRVSSVRRK 350
LNTIASEFKD KNVLLVDDSI VRGTTSEQIV EMARAAGAKK IYFASAAPEI 400
RYPNVYGIDM PTKNELIAYG RDVDEIAKLI GVDKLIFQDL DALTGSVQQE 450
NPSIQDFDCS VFTGVYVTGD ITPEYLDNIA EQRNDIAKKK REKDATNLEM 500
HNEK 504
Length:504
Mass (Da):56,327
Last modified:January 23, 2007 - v3
Checksum:iBD19FE1E621D7A2E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti118 – 1181R → L in AAF68406. 1 Publication
Sequence conflicti428 – 4281K → N in AAF68406. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF237920 Genomic DNA. Translation: AAF68406.1.
AE004439 Genomic DNA. Translation: AAK02785.1.
RefSeqiNP_245638.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK02785; AAK02785; PM0701.
GeneIDi1244048.
KEGGipmu:PM0701.
PATRICi22870596. VBIPasMul88067_0709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF237920 Genomic DNA. Translation: AAF68406.1 .
AE004439 Genomic DNA. Translation: AAK02785.1 .
RefSeqi NP_245638.1. NC_002663.1.

3D structure databases

ProteinModelPortali Q9L6B8.
SMRi Q9L6B8. Positions 2-477.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272843.PM0701.

Protein family/group databases

MEROPSi C44.001.

Proteomic databases

PRIDEi Q9L6B8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK02785 ; AAK02785 ; PM0701 .
GeneIDi 1244048.
KEGGi pmu:PM0701.
PATRICi 22870596. VBIPasMul88067_0709.

Phylogenomic databases

eggNOGi COG0034.
HOGENOMi HOG000033687.
KOi K00764.
OMAi AARVHMG.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00124 .
BioCyci PMUL272843:GC8W-726-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
3.60.20.10. 1 hit.
InterProi IPR005854. Amd_phspho_trans.
IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR029055. Ntn_hydrolases_N.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00310. GATase_2. 2 hits.
PF00156. Pribosyltran. 1 hit.
[Graphical view ]
PIRSFi PIRSF000485. Amd_phspho_trans. 1 hit.
SUPFAMi SSF53271. SSF53271. 1 hit.
SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01134. purF. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Pasteurella multocida virulence genes in a septicemic mouse model using signature-tagged mutagenesis."
    Fuller T.E., Kennedy M.J., Lowery D.E.
    Microb. Pathog. 29:25-38(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pm70.

Entry informationi

Entry nameiPUR1_PASMU
AccessioniPrimary (citable) accession number: Q9L6B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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