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Q9L6B7

- IMDH_PASMU

UniProt

Q9L6B7 - IMDH_PASMU

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Protein
Inosine-5'-monophosphate dehydrogenase
Gene
guaB, PM0295
Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth By similarity.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium By similarity.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei248 – 2481NAD By similarity
Metal bindingi300 – 3001Potassium; via carbonyl oxygen By similarity
Metal bindingi302 – 3021Potassium; via carbonyl oxygen By similarity
Binding sitei303 – 3031IMP By similarity
Active sitei305 – 3051Thioimidate intermediate By similarity
Metal bindingi305 – 3051Potassium; via carbonyl oxygen By similarity
Binding sitei415 – 4151IMP By similarity
Metal bindingi469 – 4691Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi470 – 4701Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi471 – 4711Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi248 – 2503NAD By similarity
Nucleotide bindingi298 – 3003NAD By similarity

GO - Molecular functioni

  1. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  2. adenyl nucleotide binding Source: InterPro
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

BioCyciPMUL272843:GC8W-299-MONOMER.
UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenase (EC:1.1.1.205)
Short name:
IMP dehydrogenase
Short name:
IMPD
Short name:
IMPDH
Gene namesi
Name:guaB
Ordered Locus Names:PM0295
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
ProteomesiUP000000809: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487Inosine-5'-monophosphate dehydrogenaseUniRule annotation
PRO_0000093703Add
BLAST

Proteomic databases

PRIDEiQ9L6B7.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272843.PM0295.

Structurei

3D structure databases

ProteinModelPortaliQ9L6B7.
SMRiQ9L6B7. Positions 3-485.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 14957CBS 1
Add
BLAST
Domaini153 – 21462CBS 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni338 – 3403IMP binding By similarity
Regioni361 – 3622IMP binding By similarity
Regioni385 – 3895IMP binding By similarity

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiCOG0517.
HOGENOMiHOG000165755.
KOiK00088.
OMAiHGHSKNI.
OrthoDBiEOG6GTZPV.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9L6B7-1 [UniParc]FASTAAdd to Basket

« Hide

MLRVIKEALT FDDVLLVPAH STVLPNTADL STQLTKTIRL NIPMLSAAMD    50
TVTETKLAIS LAQEGGIGFI HKNMSIERQA ERVRKVKKFE SGIVSDPVTV 100
SPTLSLAELS ELVKKNGFAS FPVVDDEKNL VGIITGRDTR FVTDLNKTVA 150
DFMTPKARLV TVKRNASRDE IFGLMHTHRV EKVLVVSDDF KLKGMITLKD 200
YQKSEQKPQA CKDEFGRLRV GAAVGAGPGN EERIDALVKA GVDVLLIDSS 250
HGHSEGVLQR VRETRAKYPD LPIVAGNVAT AEGAIALADA GASAVKVGIG 300
PGSICTTRIV TGVGVPQITA IADAAEALKD RGIPVIADGG IRFSGDISKA 350
IAAGASCVMV GSMFAGTEEA PGEIELYQGR AFKSYRGMGS LGAMSKGSSD 400
RYFQSDNAAD KLVPEGIEGR IPYKGFLKEI IHQQMGGLRS CMGLTGCATI 450
DELRTKAQFV RISGAGIQES HVHDVTITKE APNYRMG 487
Length:487
Mass (Da):52,008
Last modified:October 1, 2000 - v1
Checksum:i0871DB08893B8FCA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF237921 Genomic DNA. Translation: AAF68407.1.
AE004439 Genomic DNA. Translation: AAK02379.1.
RefSeqiNP_245232.1. NC_002663.1.
WP_005725353.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK02379; AAK02379; PM0295.
GeneIDi1243642.
KEGGipmu:PM0295.
PATRICi22869746. VBIPasMul88067_0305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF237921 Genomic DNA. Translation: AAF68407.1 .
AE004439 Genomic DNA. Translation: AAK02379.1 .
RefSeqi NP_245232.1. NC_002663.1.
WP_005725353.1. NC_002663.1.

3D structure databases

ProteinModelPortali Q9L6B7.
SMRi Q9L6B7. Positions 3-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272843.PM0295.

Proteomic databases

PRIDEi Q9L6B7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK02379 ; AAK02379 ; PM0295 .
GeneIDi 1243642.
KEGGi pmu:PM0295.
PATRICi 22869746. VBIPasMul88067_0305.

Phylogenomic databases

eggNOGi COG0517.
HOGENOMi HOG000165755.
KOi K00088.
OMAi HGHSKNI.
OrthoDBi EOG6GTZPV.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .
BioCyci PMUL272843:GC8W-299-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Pasteurella multocida virulence genes in a septicemic mouse model using signature-tagged mutagenesis."
    Fuller T.E., Kennedy M.J., Lowery D.E.
    Microb. Pathog. 29:25-38(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pm70.

Entry informationi

Entry nameiIMDH_PASMU
AccessioniPrimary (citable) accession number: Q9L6B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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