Q9L6B7 (IMDH_PASMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inosine-5'-monophosphate dehydrogenase
Short name=IMP dehydrogenase
Short name=IMPD
Short name=IMPDH
EC=1.1.1.205

Gene names

Name:	guaB
Ordered Locus Names:	PM0295

Organism

Pasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]

Taxonomic identifier

272843 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.
Pathway	Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the IMPDH/GMPR family. Contains 2 CBS domains.

Ontologies

Keywords
Biological process	GMP biosynthesis Purine biosynthesis
Domain	CBS domain Repeat
Ligand	Metal-binding NAD Potassium
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	GMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	IMP dehydrogenase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 487	487	Inosine-5'-monophosphate dehydrogenase		PRO_0000093703
Regions
	Domain	93 – 149	57	CBS 1
	Domain	153 – 214	62	CBS 2
	Nucleotide binding	227 – 250	24	NAD By similarity
Sites
	Active site	305	1	Thioimidate intermediate By similarity
	Metal binding	300	1	Potassium; via carbonyl oxygen By similarity
	Metal binding	302	1	Potassium; via carbonyl oxygen By similarity
	Binding site	338	1	IMP By similarity
	Binding site	385	1	IMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9L6B7 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 0871DB08893B8FCA	FASTA	487	52,008
	10 20 30 40 50 60 MLRVIKEALT FDDVLLVPAH STVLPNTADL STQLTKTIRL NIPMLSAAMD TVTETKLAIS 70 80 90 100 110 120 LAQEGGIGFI HKNMSIERQA ERVRKVKKFE SGIVSDPVTV SPTLSLAELS ELVKKNGFAS 130 140 150 160 170 180 FPVVDDEKNL VGIITGRDTR FVTDLNKTVA DFMTPKARLV TVKRNASRDE IFGLMHTHRV 190 200 210 220 230 240 EKVLVVSDDF KLKGMITLKD YQKSEQKPQA CKDEFGRLRV GAAVGAGPGN EERIDALVKA 250 260 270 280 290 300 GVDVLLIDSS HGHSEGVLQR VRETRAKYPD LPIVAGNVAT AEGAIALADA GASAVKVGIG 310 320 330 340 350 360 PGSICTTRIV TGVGVPQITA IADAAEALKD RGIPVIADGG IRFSGDISKA IAAGASCVMV 370 380 390 400 410 420 GSMFAGTEEA PGEIELYQGR AFKSYRGMGS LGAMSKGSSD RYFQSDNAAD KLVPEGIEGR 430 440 450 460 470 480 IPYKGFLKEI IHQQMGGLRS CMGLTGCATI DELRTKAQFV RISGAGIQES HVHDVTITKE APNYRMG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of Pasteurella multocida virulence genes in a septicemic mouse model using signature-tagged mutagenesis." Fuller T.E., Kennedy M.J., Lowery D.E. Microb. Pathog. 29:25-38(2000) [PubMed: 10873488] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genomic sequence of Pasteurella multocida Pm70." May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pm70.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF237921 Genomic DNA. Translation: AAF68407.1. AE004439 Genomic DNA. Translation: AAK02379.1.
RefSeq	NP_245232.1. NC_002663.1.
3D structure databases
ProteinModelPortal	Q9L6B7.
SMR	Q9L6B7. Positions 3-485.
ModBase	Search...
Proteomic databases
PRIDE	Q9L6B7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1243642.
GenomeReviews	Gene locus PM0295 in contig AE004439_GR.
KEGG	pmu:PM0295.
NMPDR	fig|272843.1.peg.295.
PATRIC	22869746. VBIPasMul88067_0305.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG298985.
OMA	GIGIVHK.
ProtClustDB	PRK05567.
Enzyme and pathway databases
BioCyc	PMUL272843:PM0295-MONOMER.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR000644. Cysta_beta_synth_core. IPR005990. IMP_DH. IPR018529. IMP_DH-rel. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00088.
PANTHER	PTHR11911:SF6. IMP_DH_GMPRtase. 1 hit.
Pfam	PF00571. CBS. 2 hits. PF00478. IMPDH. 1 hit. [Graphical view]
PIRSF	PIRSF000130. IMPDH. 1 hit.
SMART	SM00116. CBS. 2 hits. [Graphical view]
TIGRFAMs	TIGR01302. IMP_dehydrog. 1 hit.
PROSITE	PS51371. CBS. 2 hits. PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IMDH_PASMU

Accession

Primary (citable) accession number: Q9L6B7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 4, 2001
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program