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Q9L646 (NRDD_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anaerobic ribonucleoside-triphosphate reductase

EC=1.17.4.2
Gene names
Name:nrdD
Ordered Locus Names:STM4452
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length712 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Subunit structure

Tetramer consisting of 2 alpha (NrdD) and 2 beta (NrdG) subunits.

Sequence similarities

Belongs to the anaerobic ribonucleoside-triphosphate reductase family.

Contains 1 ATP-cone domain.

Contains 1 glycine radical domain.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionOxidoreductase
   PTMOrganic radical
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ribonucleoside-triphosphate reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 712712Anaerobic ribonucleoside-triphosphate reductase
PRO_0000166685

Regions

Domain3 – 9290ATP-cone
Domain583 – 708126Glycine radical

Amino acid modifications

Modified residue6811Glycine radical By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9L646 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 1D907CF6B758D7E4

FASTA71279,959
        10         20         30         40         50         60 
MTPHVMKRDG CKVPFKSERI KEAILRAAKA AGVDDADYCA TVAEVVSSQM NARSQVDINE 

        70         80         90        100        110        120 
IQTAVENQLM SGPYKQLARA YIEYRHDRDI QREKRGRLNQ EIRGLVEQTN SALLNENANK 

       130        140        150        160        170        180 
DSKVIPTQRD LLAGIVAKHY ARQHLLPRDV VQAHERGDIH YHDLDYSPFF PMFNCMLIDL 

       190        200        210        220        230        240 
KGMLTQGFKM GNAEIEPPKS ISTATAVTAQ IIAQVASHIY GGTTINRIDE VLAPFVTESY 

       250        260        270        280        290        300 
NKHRKTADEW QIPDAEGYAR SRTEKECYDA FQSLEYEVNT LHTANGQTPF VTFGFGLGTS 

       310        320        330        340        350        360 
WESRLIQASI LRNRIAGLGK NRKTAVFPKL VFAIRDGLNH KFGDPNYDIK QLALECASKR 

       370        380        390        400        410        420 
MYPDILNYDQ VVKVTGSFKT PMGCRSFLGV WENENGEQIH DGRNNLGVIS LNLPRIALEA 

       430        440        450        460        470        480 
KGDETAFWKL LDERLALARK ALMTRIARLE GVKARVAPIL YMEGACGVRL KADDDVSEIF 

       490        500        510        520        530        540 
KNGRASISLG YIGIHETINA LFGGEHLYDS EQLRAKGIAI VERLRQAVDQ WKDETGYGFS 

       550        560        570        580        590        600 
LYSTPSENLC DRFCRLDTAE FGVVPGVTDK GYYTNSFHLD VEKKVNPYDK IDFEAPYPPL 

       610        620        630        640        650        660 
ANGGFICYGE YPNIQHNLKA LEDVWDYSYQ HVPYYGTNTP IDECYECGFT GEFECTSKGF 

       670        680        690        700        710 
TCPKCGNHDA ARVSVTRRVC GYLGSPDARP FNAGKQEEVK RRVKHLGNGQ IG 

« Hide

References

« Hide 'large scale' references
[1]"Genetic regulation and mutant characterization of anaerobic ribonucleotide reductase in Salmonella typhimurium."
Ng W., Wong K., Kwan H.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF242390 Genomic DNA. Translation: AAF60351.1.
AE006468 Genomic DNA. Translation: AAL23272.1.
RefSeqNP_463313.1. NC_003197.1.

3D structure databases

ProteinModelPortalQ9L646.
SMRQ9L646. Positions 121-669.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM4452.

Proteomic databases

PaxDbQ9L646.
PRIDEQ9L646.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL23272; AAL23272; STM4452.
GeneID1255978.
KEGGstm:STM4452.
PATRIC32387837. VBISalEnt20916_4682.

Phylogenomic databases

eggNOGCOG1328.
HOGENOMHOG000222474.
KOK00527.
OMAHKTAVFP.
OrthoDBEOG622PMK.
ProtClustDBPRK09263.

Enzyme and pathway databases

BioCycSENT99287:GCTI-4481-MONOMER.

Family and domain databases

InterProIPR005144. ATP-cone.
IPR019777. Form_AcTrfase_GR_CS.
IPR001150. Gly_radical.
IPR012833. NrdD.
[Graphical view]
PfamPF03477. ATP-cone. 1 hit.
[Graphical view]
TIGRFAMsTIGR02487. NrdD. 1 hit.
PROSITEPS51161. ATP_CONE. 1 hit.
PS00850. GLY_RADICAL_1. 1 hit.
PS51149. GLY_RADICAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNRDD_SALTY
AccessionPrimary (citable) accession number: Q9L646
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 1, 2000
Last modified: November 13, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families