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Q9L646

- NRDD_SALTY

UniProt

Q9L646 - NRDD_SALTY

Protein

Anaerobic ribonucleoside-triphosphate reductase

Gene

nrdD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-4481-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anaerobic ribonucleoside-triphosphate reductase (EC:1.17.4.2)
    Gene namesi
    Name:nrdD
    Ordered Locus Names:STM4452
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 712712Anaerobic ribonucleoside-triphosphate reductasePRO_0000166685Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei681 – 6811Glycine radicalPROSITE-ProRule annotation

    Keywords - PTMi

    Organic radical

    Proteomic databases

    PaxDbiQ9L646.
    PRIDEiQ9L646.

    Interactioni

    Subunit structurei

    Tetramer consisting of 2 alpha (NrdD) and 2 beta (NrdG) subunits.

    Protein-protein interaction databases

    STRINGi99287.STM4452.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9L646.
    SMRiQ9L646. Positions 121-669.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 9290ATP-conePROSITE-ProRule annotationAdd
    BLAST
    Domaini583 – 708126Glycine radicalPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ATP-cone domain.PROSITE-ProRule annotation
    Contains 1 glycine radical domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1328.
    HOGENOMiHOG000222474.
    KOiK00527.
    OMAiKRRVKHM.
    OrthoDBiEOG622PMK.
    PhylomeDBiQ9L646.

    Family and domain databases

    InterProiIPR005144. ATP-cone.
    IPR019777. Form_AcTrfase_GR_CS.
    IPR001150. Gly_radical.
    IPR012833. NrdD.
    [Graphical view]
    PfamiPF03477. ATP-cone. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02487. NrdD. 1 hit.
    PROSITEiPS51161. ATP_CONE. 1 hit.
    PS00850. GLY_RADICAL_1. 1 hit.
    PS51149. GLY_RADICAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9L646-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPHVMKRDG CKVPFKSERI KEAILRAAKA AGVDDADYCA TVAEVVSSQM    50
    NARSQVDINE IQTAVENQLM SGPYKQLARA YIEYRHDRDI QREKRGRLNQ 100
    EIRGLVEQTN SALLNENANK DSKVIPTQRD LLAGIVAKHY ARQHLLPRDV 150
    VQAHERGDIH YHDLDYSPFF PMFNCMLIDL KGMLTQGFKM GNAEIEPPKS 200
    ISTATAVTAQ IIAQVASHIY GGTTINRIDE VLAPFVTESY NKHRKTADEW 250
    QIPDAEGYAR SRTEKECYDA FQSLEYEVNT LHTANGQTPF VTFGFGLGTS 300
    WESRLIQASI LRNRIAGLGK NRKTAVFPKL VFAIRDGLNH KFGDPNYDIK 350
    QLALECASKR MYPDILNYDQ VVKVTGSFKT PMGCRSFLGV WENENGEQIH 400
    DGRNNLGVIS LNLPRIALEA KGDETAFWKL LDERLALARK ALMTRIARLE 450
    GVKARVAPIL YMEGACGVRL KADDDVSEIF KNGRASISLG YIGIHETINA 500
    LFGGEHLYDS EQLRAKGIAI VERLRQAVDQ WKDETGYGFS LYSTPSENLC 550
    DRFCRLDTAE FGVVPGVTDK GYYTNSFHLD VEKKVNPYDK IDFEAPYPPL 600
    ANGGFICYGE YPNIQHNLKA LEDVWDYSYQ HVPYYGTNTP IDECYECGFT 650
    GEFECTSKGF TCPKCGNHDA ARVSVTRRVC GYLGSPDARP FNAGKQEEVK 700
    RRVKHLGNGQ IG 712
    Length:712
    Mass (Da):79,959
    Last modified:October 1, 2000 - v1
    Checksum:i1D907CF6B758D7E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF242390 Genomic DNA. Translation: AAF60351.1.
    AE006468 Genomic DNA. Translation: AAL23272.1.
    RefSeqiNP_463313.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL23272; AAL23272; STM4452.
    GeneIDi1255978.
    KEGGistm:STM4452.
    PATRICi32387837. VBISalEnt20916_4682.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF242390 Genomic DNA. Translation: AAF60351.1 .
    AE006468 Genomic DNA. Translation: AAL23272.1 .
    RefSeqi NP_463313.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali Q9L646.
    SMRi Q9L646. Positions 121-669.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM4452.

    Proteomic databases

    PaxDbi Q9L646.
    PRIDEi Q9L646.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL23272 ; AAL23272 ; STM4452 .
    GeneIDi 1255978.
    KEGGi stm:STM4452.
    PATRICi 32387837. VBISalEnt20916_4682.

    Phylogenomic databases

    eggNOGi COG1328.
    HOGENOMi HOG000222474.
    KOi K00527.
    OMAi KRRVKHM.
    OrthoDBi EOG622PMK.
    PhylomeDBi Q9L646.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-4481-MONOMER.

    Family and domain databases

    InterProi IPR005144. ATP-cone.
    IPR019777. Form_AcTrfase_GR_CS.
    IPR001150. Gly_radical.
    IPR012833. NrdD.
    [Graphical view ]
    Pfami PF03477. ATP-cone. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02487. NrdD. 1 hit.
    PROSITEi PS51161. ATP_CONE. 1 hit.
    PS00850. GLY_RADICAL_1. 1 hit.
    PS51149. GLY_RADICAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic regulation and mutant characterization of anaerobic ribonucleotide reductase in Salmonella typhimurium."
      Ng W., Wong K., Kwan H.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiNRDD_SALTY
    AccessioniPrimary (citable) accession number: Q9L646
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3