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Protein

Anaerobic ribonucleoside-triphosphate reductase

Gene

nrdD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of ribonucleotides into deoxyribonucleotides, which are required for DNA synthesis and repair.By similarity

Catalytic activityi

Ribonucleoside 5'-triphosphate + formate = 2'-deoxyribonucleoside 5'-triphosphate + CO2 + H2O.By similarity

Enzyme regulationi

Activated under anaerobic conditions by NrdG, a tightly associated activase. Activation involves the formation of a glycyl radical at Gly-681.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi644ZincBy similarity1
Metal bindingi647ZincBy similarity1
Metal bindingi662ZincBy similarity1
Metal bindingi665ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic ribonucleoside-triphosphate reductaseBy similarity (EC:1.1.98.6By similarity)
Alternative name(s):
Class III ribonucleoside-triphosphate reductaseBy similarity
Gene namesi
Name:nrdD
Ordered Locus Names:STM4452
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001666851 – 712Anaerobic ribonucleoside-triphosphate reductaseAdd BLAST712

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei681Glycine radicalPROSITE-ProRule annotation1

Keywords - PTMi

Organic radical

Proteomic databases

PaxDbiQ9L646.
PRIDEiQ9L646.

Interactioni

Subunit structurei

Forms a tetramer composed of two NrdD and two NrdG subunits.By similarity

Protein-protein interaction databases

STRINGi99287.STM4452.

Structurei

3D structure databases

ProteinModelPortaliQ9L646.
SMRiQ9L646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 92ATP-conePROSITE-ProRule annotationAdd BLAST90
Domaini583 – 708Glycine radicalPROSITE-ProRule annotationAdd BLAST126

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CJD. Bacteria.
COG1328. LUCA.
HOGENOMiHOG000222474.
KOiK21636.
OMAiQSEWAGA.
PhylomeDBiQ9L646.

Family and domain databases

CDDicd01675. RNR_III. 1 hit.
InterProiView protein in InterPro
IPR005144. ATP-cone_dom.
IPR019777. Form_AcTrfase_GR_CS.
IPR001150. Gly_radical.
IPR012833. NrdD.
PfamiView protein in Pfam
PF03477. ATP-cone. 1 hit.
PF13597. NRDD. 1 hit.
TIGRFAMsiTIGR02487. NrdD. 1 hit.
PROSITEiView protein in PROSITE
PS51161. ATP_CONE. 1 hit.
PS00850. GLY_RADICAL_1. 1 hit.
PS51149. GLY_RADICAL_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9L646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPHVMKRDG CKVPFKSERI KEAILRAAKA AGVDDADYCA TVAEVVSSQM
60 70 80 90 100
NARSQVDINE IQTAVENQLM SGPYKQLARA YIEYRHDRDI QREKRGRLNQ
110 120 130 140 150
EIRGLVEQTN SALLNENANK DSKVIPTQRD LLAGIVAKHY ARQHLLPRDV
160 170 180 190 200
VQAHERGDIH YHDLDYSPFF PMFNCMLIDL KGMLTQGFKM GNAEIEPPKS
210 220 230 240 250
ISTATAVTAQ IIAQVASHIY GGTTINRIDE VLAPFVTESY NKHRKTADEW
260 270 280 290 300
QIPDAEGYAR SRTEKECYDA FQSLEYEVNT LHTANGQTPF VTFGFGLGTS
310 320 330 340 350
WESRLIQASI LRNRIAGLGK NRKTAVFPKL VFAIRDGLNH KFGDPNYDIK
360 370 380 390 400
QLALECASKR MYPDILNYDQ VVKVTGSFKT PMGCRSFLGV WENENGEQIH
410 420 430 440 450
DGRNNLGVIS LNLPRIALEA KGDETAFWKL LDERLALARK ALMTRIARLE
460 470 480 490 500
GVKARVAPIL YMEGACGVRL KADDDVSEIF KNGRASISLG YIGIHETINA
510 520 530 540 550
LFGGEHLYDS EQLRAKGIAI VERLRQAVDQ WKDETGYGFS LYSTPSENLC
560 570 580 590 600
DRFCRLDTAE FGVVPGVTDK GYYTNSFHLD VEKKVNPYDK IDFEAPYPPL
610 620 630 640 650
ANGGFICYGE YPNIQHNLKA LEDVWDYSYQ HVPYYGTNTP IDECYECGFT
660 670 680 690 700
GEFECTSKGF TCPKCGNHDA ARVSVTRRVC GYLGSPDARP FNAGKQEEVK
710
RRVKHLGNGQ IG
Length:712
Mass (Da):79,959
Last modified:October 1, 2000 - v1
Checksum:i1D907CF6B758D7E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242390 Genomic DNA. Translation: AAF60351.1.
AE006468 Genomic DNA. Translation: AAL23272.1.
RefSeqiNP_463313.1. NC_003197.2.
WP_000187818.1. NC_003197.2.

Genome annotation databases

EnsemblBacteriaiAAL23272; AAL23272; STM4452.
GeneIDi1255978.
KEGGistm:STM4452.
PATRICifig|99287.12.peg.4682.

Similar proteinsi

Entry informationi

Entry nameiNRDD_SALTY
AccessioniPrimary (citable) accession number: Q9L646
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families