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Q9L646

- NRDD_SALTY

UniProt

Q9L646 - NRDD_SALTY

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Protein

Anaerobic ribonucleoside-triphosphate reductase

Gene

nrdD

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4481-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Gene namesi
Name:nrdD
Ordered Locus Names:STM4452
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 712712Anaerobic ribonucleoside-triphosphate reductasePRO_0000166685Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei681 – 6811Glycine radicalPROSITE-ProRule annotation

Keywords - PTMi

Organic radical

Proteomic databases

PaxDbiQ9L646.
PRIDEiQ9L646.

Interactioni

Subunit structurei

Tetramer consisting of 2 alpha (NrdD) and 2 beta (NrdG) subunits.

Protein-protein interaction databases

STRINGi99287.STM4452.

Structurei

3D structure databases

ProteinModelPortaliQ9L646.
SMRiQ9L646. Positions 121-669.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 9290ATP-conePROSITE-ProRule annotationAdd
BLAST
Domaini583 – 708126Glycine radicalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-cone domain.PROSITE-ProRule annotation
Contains 1 glycine radical domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1328.
HOGENOMiHOG000222474.
KOiK00527.
OMAiKRRVKHM.
OrthoDBiEOG622PMK.
PhylomeDBiQ9L646.

Family and domain databases

InterProiIPR005144. ATP-cone.
IPR019777. Form_AcTrfase_GR_CS.
IPR001150. Gly_radical.
IPR012833. NrdD.
[Graphical view]
PfamiPF03477. ATP-cone. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02487. NrdD. 1 hit.
PROSITEiPS51161. ATP_CONE. 1 hit.
PS00850. GLY_RADICAL_1. 1 hit.
PS51149. GLY_RADICAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9L646-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPHVMKRDG CKVPFKSERI KEAILRAAKA AGVDDADYCA TVAEVVSSQM
60 70 80 90 100
NARSQVDINE IQTAVENQLM SGPYKQLARA YIEYRHDRDI QREKRGRLNQ
110 120 130 140 150
EIRGLVEQTN SALLNENANK DSKVIPTQRD LLAGIVAKHY ARQHLLPRDV
160 170 180 190 200
VQAHERGDIH YHDLDYSPFF PMFNCMLIDL KGMLTQGFKM GNAEIEPPKS
210 220 230 240 250
ISTATAVTAQ IIAQVASHIY GGTTINRIDE VLAPFVTESY NKHRKTADEW
260 270 280 290 300
QIPDAEGYAR SRTEKECYDA FQSLEYEVNT LHTANGQTPF VTFGFGLGTS
310 320 330 340 350
WESRLIQASI LRNRIAGLGK NRKTAVFPKL VFAIRDGLNH KFGDPNYDIK
360 370 380 390 400
QLALECASKR MYPDILNYDQ VVKVTGSFKT PMGCRSFLGV WENENGEQIH
410 420 430 440 450
DGRNNLGVIS LNLPRIALEA KGDETAFWKL LDERLALARK ALMTRIARLE
460 470 480 490 500
GVKARVAPIL YMEGACGVRL KADDDVSEIF KNGRASISLG YIGIHETINA
510 520 530 540 550
LFGGEHLYDS EQLRAKGIAI VERLRQAVDQ WKDETGYGFS LYSTPSENLC
560 570 580 590 600
DRFCRLDTAE FGVVPGVTDK GYYTNSFHLD VEKKVNPYDK IDFEAPYPPL
610 620 630 640 650
ANGGFICYGE YPNIQHNLKA LEDVWDYSYQ HVPYYGTNTP IDECYECGFT
660 670 680 690 700
GEFECTSKGF TCPKCGNHDA ARVSVTRRVC GYLGSPDARP FNAGKQEEVK
710
RRVKHLGNGQ IG
Length:712
Mass (Da):79,959
Last modified:October 1, 2000 - v1
Checksum:i1D907CF6B758D7E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF242390 Genomic DNA. Translation: AAF60351.1.
AE006468 Genomic DNA. Translation: AAL23272.1.
RefSeqiNP_463313.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL23272; AAL23272; STM4452.
GeneIDi1255978.
KEGGistm:STM4452.
PATRICi32387837. VBISalEnt20916_4682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF242390 Genomic DNA. Translation: AAF60351.1 .
AE006468 Genomic DNA. Translation: AAL23272.1 .
RefSeqi NP_463313.1. NC_003197.1.

3D structure databases

ProteinModelPortali Q9L646.
SMRi Q9L646. Positions 121-669.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM4452.

Proteomic databases

PaxDbi Q9L646.
PRIDEi Q9L646.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL23272 ; AAL23272 ; STM4452 .
GeneIDi 1255978.
KEGGi stm:STM4452.
PATRICi 32387837. VBISalEnt20916_4682.

Phylogenomic databases

eggNOGi COG1328.
HOGENOMi HOG000222474.
KOi K00527.
OMAi KRRVKHM.
OrthoDBi EOG622PMK.
PhylomeDBi Q9L646.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-4481-MONOMER.

Family and domain databases

InterProi IPR005144. ATP-cone.
IPR019777. Form_AcTrfase_GR_CS.
IPR001150. Gly_radical.
IPR012833. NrdD.
[Graphical view ]
Pfami PF03477. ATP-cone. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02487. NrdD. 1 hit.
PROSITEi PS51161. ATP_CONE. 1 hit.
PS00850. GLY_RADICAL_1. 1 hit.
PS51149. GLY_RADICAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic regulation and mutant characterization of anaerobic ribonucleotide reductase in Salmonella typhimurium."
    Ng W., Wong K., Kwan H.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiNRDD_SALTY
AccessioniPrimary (citable) accession number: Q9L646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3