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Q9L646

- NRDD_SALTY

UniProt

Q9L646 - NRDD_SALTY

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Protein

Anaerobic ribonucleoside-triphosphate reductase

Gene
nrdD, STM4452
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4481-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Gene namesi
Name:nrdD
Ordered Locus Names:STM4452
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 712712Anaerobic ribonucleoside-triphosphate reductasePRO_0000166685Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei681 – 6811Glycine radical By similarity

Keywords - PTMi

Organic radical

Proteomic databases

PaxDbiQ9L646.
PRIDEiQ9L646.

Interactioni

Subunit structurei

Tetramer consisting of 2 alpha (NrdD) and 2 beta (NrdG) subunits.

Protein-protein interaction databases

STRINGi99287.STM4452.

Structurei

3D structure databases

ProteinModelPortaliQ9L646.
SMRiQ9L646. Positions 121-669.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 9290ATP-coneAdd
BLAST
Domaini583 – 708126Glycine radicalAdd
BLAST

Sequence similaritiesi

Contains 1 ATP-cone domain.

Phylogenomic databases

eggNOGiCOG1328.
HOGENOMiHOG000222474.
KOiK00527.
OMAiKRRVKHM.
OrthoDBiEOG622PMK.
PhylomeDBiQ9L646.

Family and domain databases

InterProiIPR005144. ATP-cone.
IPR019777. Form_AcTrfase_GR_CS.
IPR001150. Gly_radical.
IPR012833. NrdD.
[Graphical view]
PfamiPF03477. ATP-cone. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02487. NrdD. 1 hit.
PROSITEiPS51161. ATP_CONE. 1 hit.
PS00850. GLY_RADICAL_1. 1 hit.
PS51149. GLY_RADICAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9L646-1 [UniParc]FASTAAdd to Basket

« Hide

MTPHVMKRDG CKVPFKSERI KEAILRAAKA AGVDDADYCA TVAEVVSSQM    50
NARSQVDINE IQTAVENQLM SGPYKQLARA YIEYRHDRDI QREKRGRLNQ 100
EIRGLVEQTN SALLNENANK DSKVIPTQRD LLAGIVAKHY ARQHLLPRDV 150
VQAHERGDIH YHDLDYSPFF PMFNCMLIDL KGMLTQGFKM GNAEIEPPKS 200
ISTATAVTAQ IIAQVASHIY GGTTINRIDE VLAPFVTESY NKHRKTADEW 250
QIPDAEGYAR SRTEKECYDA FQSLEYEVNT LHTANGQTPF VTFGFGLGTS 300
WESRLIQASI LRNRIAGLGK NRKTAVFPKL VFAIRDGLNH KFGDPNYDIK 350
QLALECASKR MYPDILNYDQ VVKVTGSFKT PMGCRSFLGV WENENGEQIH 400
DGRNNLGVIS LNLPRIALEA KGDETAFWKL LDERLALARK ALMTRIARLE 450
GVKARVAPIL YMEGACGVRL KADDDVSEIF KNGRASISLG YIGIHETINA 500
LFGGEHLYDS EQLRAKGIAI VERLRQAVDQ WKDETGYGFS LYSTPSENLC 550
DRFCRLDTAE FGVVPGVTDK GYYTNSFHLD VEKKVNPYDK IDFEAPYPPL 600
ANGGFICYGE YPNIQHNLKA LEDVWDYSYQ HVPYYGTNTP IDECYECGFT 650
GEFECTSKGF TCPKCGNHDA ARVSVTRRVC GYLGSPDARP FNAGKQEEVK 700
RRVKHLGNGQ IG 712
Length:712
Mass (Da):79,959
Last modified:October 1, 2000 - v1
Checksum:i1D907CF6B758D7E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF242390 Genomic DNA. Translation: AAF60351.1.
AE006468 Genomic DNA. Translation: AAL23272.1.
RefSeqiNP_463313.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL23272; AAL23272; STM4452.
GeneIDi1255978.
KEGGistm:STM4452.
PATRICi32387837. VBISalEnt20916_4682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF242390 Genomic DNA. Translation: AAF60351.1 .
AE006468 Genomic DNA. Translation: AAL23272.1 .
RefSeqi NP_463313.1. NC_003197.1.

3D structure databases

ProteinModelPortali Q9L646.
SMRi Q9L646. Positions 121-669.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM4452.

Proteomic databases

PaxDbi Q9L646.
PRIDEi Q9L646.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL23272 ; AAL23272 ; STM4452 .
GeneIDi 1255978.
KEGGi stm:STM4452.
PATRICi 32387837. VBISalEnt20916_4682.

Phylogenomic databases

eggNOGi COG1328.
HOGENOMi HOG000222474.
KOi K00527.
OMAi KRRVKHM.
OrthoDBi EOG622PMK.
PhylomeDBi Q9L646.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-4481-MONOMER.

Family and domain databases

InterProi IPR005144. ATP-cone.
IPR019777. Form_AcTrfase_GR_CS.
IPR001150. Gly_radical.
IPR012833. NrdD.
[Graphical view ]
Pfami PF03477. ATP-cone. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02487. NrdD. 1 hit.
PROSITEi PS51161. ATP_CONE. 1 hit.
PS00850. GLY_RADICAL_1. 1 hit.
PS51149. GLY_RADICAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic regulation and mutant characterization of anaerobic ribonucleotide reductase in Salmonella typhimurium."
    Ng W., Wong K., Kwan H.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiNRDD_SALTY
AccessioniPrimary (citable) accession number: Q9L646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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