Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-lactamase

Gene

blaCTX-M-9a

Organism
Escherichia coli
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Antibiotic resistanceUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotationSAAS annotation (EC:3.5.2.6UniRule annotationSAAS annotation)
Gene namesi
Name:blaCTX-M-9aImported
Synonyms:blaCTX-M-9Imported, blaCTX-M-9bImported
Encoded oniPlasmid pMSP071Imported
Plasmid pOZ173Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500771702329 – 291Beta-lactamaseSequence analysisAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29Pyrrolidone carboxylic acidCombined sources1

Keywords - PTMi

Pyrrolidone carboxylic acidCombined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YLJX-ray0.98A29-291[»]
1YM1X-ray1.12A/B29-291[»]
1YMSX-ray1.60A/B29-291[»]
1YMXX-ray1.70A/B29-291[»]
2P74X-ray0.88A/B29-288[»]
3G2YX-ray1.31A/B29-291[»]
3G2ZX-ray1.50A/B29-291[»]
3G30X-ray1.80A29-291[»]
3G31X-ray1.70A/B29-291[»]
3G32X-ray1.31A/B29-291[»]
3G34X-ray1.31A/B29-291[»]
3G35X-ray1.41A/B29-291[»]
3HLWX-ray1.50A/B29-291[»]
3HREX-ray1.45A/B29-291[»]
3HUOX-ray1.50A/B29-291[»]
3HVFX-ray1.50A/B29-291[»]
3Q07X-ray1.50A/B29-291[»]
3Q1FX-ray1.50A/B29-291[»]
4DDSX-ray1.36A/B30-291[»]
4DDYX-ray1.36A/B30-291[»]
4DE0X-ray1.12A/B30-291[»]
4DE1X-ray1.26A/B30-291[»]
4DE2X-ray1.40A/B30-291[»]
4DE3X-ray1.44A/B30-291[»]
4LENX-ray1.50A/B29-291[»]
ProteinModelPortaliQ9L5C8.
SMRiQ9L5C8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

KOiK18767.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9L5C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTKRVQRMM FAAAACIPLL LGSAPLYAQT SAVQQKLAAL EKSSGGRLGV
60 70 80 90 100
ALIDTADNTQ VLYRGDERFP MCSTSKVMAA AAVLKQSETQ KQLLNQPVEI
110 120 130 140 150
KPADLVNYNP IAEKHVNGTM TLAELSAAAL QYSDNTAMNK LIAQLGGPGG
160 170 180 190 200
VTAFARAIGD ETFRLDRTEP TLNTAIPGDP RDTTTPRAMA QTLRQLTLGH
210 220 230 240 250
ALGETQRAQL VTWLKGNTTG AASIRAGLPT SWTAGDKTGS GDYGTTNDIA
260 270 280 290
VIWPQGRAPL VLVTYFTQPQ QNAESRRDVL ASAARIIAEG L
Length:291
Mass (Da):30,951
Last modified:October 1, 2000 - v1
Checksum:iC8CB0A7739B9469E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174129 Genomic DNA. Translation: AAF05311.2.
AF252621 Genomic DNA. Translation: AAF72529.1.
EU418915 Genomic DNA. Translation: ACM04461.1.
HM569735 Genomic DNA. Translation: ADJ19345.1.
AJ416345 Genomic DNA. Translation: CAC95176.1.
AM040708 Genomic DNA. Translation: CAJ13580.1.
RefSeqiWP_032489926.1. NG_049043.1.

Genome annotation databases

KEGGiag:AAF05311.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174129 Genomic DNA. Translation: AAF05311.2.
AF252621 Genomic DNA. Translation: AAF72529.1.
EU418915 Genomic DNA. Translation: ACM04461.1.
HM569735 Genomic DNA. Translation: ADJ19345.1.
AJ416345 Genomic DNA. Translation: CAC95176.1.
AM040708 Genomic DNA. Translation: CAJ13580.1.
RefSeqiWP_032489926.1. NG_049043.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YLJX-ray0.98A29-291[»]
1YM1X-ray1.12A/B29-291[»]
1YMSX-ray1.60A/B29-291[»]
1YMXX-ray1.70A/B29-291[»]
2P74X-ray0.88A/B29-288[»]
3G2YX-ray1.31A/B29-291[»]
3G2ZX-ray1.50A/B29-291[»]
3G30X-ray1.80A29-291[»]
3G31X-ray1.70A/B29-291[»]
3G32X-ray1.31A/B29-291[»]
3G34X-ray1.31A/B29-291[»]
3G35X-ray1.41A/B29-291[»]
3HLWX-ray1.50A/B29-291[»]
3HREX-ray1.45A/B29-291[»]
3HUOX-ray1.50A/B29-291[»]
3HVFX-ray1.50A/B29-291[»]
3Q07X-ray1.50A/B29-291[»]
3Q1FX-ray1.50A/B29-291[»]
4DDSX-ray1.36A/B30-291[»]
4DDYX-ray1.36A/B30-291[»]
4DE0X-ray1.12A/B30-291[»]
4DE1X-ray1.26A/B30-291[»]
4DE2X-ray1.40A/B30-291[»]
4DE3X-ray1.44A/B30-291[»]
4LENX-ray1.50A/B29-291[»]
ProteinModelPortaliQ9L5C8.
SMRiQ9L5C8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAF05311.

Phylogenomic databases

KOiK18767.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ9L5C8_ECOLX
AccessioniPrimary (citable) accession number: Q9L5C8
Secondary accession number(s): Q9RP34
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, PlasmidImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.