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Protein

Beta-lactamase

Gene

blaCTX-M-9a

Organism
Escherichia coli
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processAntibiotic resistanceUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotationSAAS annotation (EC:3.5.2.6UniRule annotationSAAS annotation)
Gene namesi
Name:blaCTX-M-9aImported
Synonyms:blaCTX-M-9Imported, blaCTX-M-9bImported
Encoded oniPlasmid pMSP071Imported
Plasmid pOZ173Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Pathology & Biotechi

Chemistry databases

DrugBankiDB08551. (1R)-1-(2-THIENYLACETYLAMINO)-1-(3-CARBOXYPHENYL)METHYLBORONIC ACID.
DB07808. (1S,2R)-2-[(2,5-difluorophenyl)carbamoyl]cyclopropanecarboxylic acid.
DB07823. (2S)-2-[(3aR,4R,7S,7aS)-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl]propanoic acid.
DB07055. 2-[2-(1H-tetrazol-5-yl)ethyl]-1H-isoindole-1,3(2H)-dione.
DB07865. 3-(1H-tetrazol-5-ylamino)cyclohex-2-en-1-one.
DB06889. 3-(1H-tetrazol-5-ylmethyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one.
DB07729. 3-fluoro-N-[3-(1H-tetrazol-5-yl)phenyl]benzamide.
DB07824. 4-ethyl-5-methyl-2-(1H-tetrazol-5-yl)-1,2-dihydro-3H-pyrazol-3-one.
DB02841. [(2-Ethoxy-1-Naphthoyl)Amino]Methylboronic Acid.
DB02772. Sucrose.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_501051079929 – 291Beta-lactamaseSequence analysisAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29Pyrrolidone carboxylic acidCombined sources1

Keywords - PTMi

Pyrrolidone carboxylic acidCombined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YLJX-ray0.98A29-291[»]
1YM1X-ray1.12A/B29-291[»]
1YMSX-ray1.60A/B29-291[»]
1YMXX-ray1.70A/B29-291[»]
2P74X-ray0.88A/B29-291[»]
3G2YX-ray1.31A/B29-291[»]
3G2ZX-ray1.50A/B29-291[»]
3G30X-ray1.80A29-291[»]
3G31X-ray1.70A/B29-291[»]
3G32X-ray1.31A/B29-291[»]
3G34X-ray1.31A/B29-291[»]
3G35X-ray1.41A/B29-291[»]
3HLWX-ray1.50A/B29-291[»]
3HREX-ray1.45A/B29-291[»]
3HUOX-ray1.50A/B29-291[»]
3HVFX-ray1.50A/B29-291[»]
3Q07X-ray1.50A/B29-291[»]
3Q1FX-ray1.50A/B29-291[»]
4DDSX-ray1.36A/B29-291[»]
4DDYX-ray1.36A/B29-291[»]
4DE0X-ray1.12A/B29-291[»]
4DE1X-ray1.26A/B29-291[»]
4DE2X-ray1.40A/B29-291[»]
4DE3X-ray1.44A/B29-291[»]
4LENX-ray1.50A/B29-291[»]
5UJOX-ray1.35A/B29-291[»]
SMRiQ9L5C8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

KOiK18767.

Family and domain databases

InterProiView protein in InterPro
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A.
IPR023650. Beta-lactam_class-A_AS.
PRINTSiPR00118. BLACTAMASEA.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiView protein in PROSITE
PS00146. BETA_LACTAMASE_A. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9L5C8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTKRVQRMM FAAAACIPLL LGSAPLYAQT SAVQQKLAAL EKSSGGRLGV
60 70 80 90 100
ALIDTADNTQ VLYRGDERFP MCSTSKVMAA AAVLKQSETQ KQLLNQPVEI
110 120 130 140 150
KPADLVNYNP IAEKHVNGTM TLAELSAAAL QYSDNTAMNK LIAQLGGPGG
160 170 180 190 200
VTAFARAIGD ETFRLDRTEP TLNTAIPGDP RDTTTPRAMA QTLRQLTLGH
210 220 230 240 250
ALGETQRAQL VTWLKGNTTG AASIRAGLPT SWTAGDKTGS GDYGTTNDIA
260 270 280 290
VIWPQGRAPL VLVTYFTQPQ QNAESRRDVL ASAARIIAEG L
Length:291
Mass (Da):30,951
Last modified:October 1, 2000 - v1
Checksum:iC8CB0A7739B9469E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF174129 Genomic DNA. Translation: AAF05311.2.
AF252621 Genomic DNA. Translation: AAF72529.1.
EU418915 Genomic DNA. Translation: ACM04461.1.
HM569735 Genomic DNA. Translation: ADJ19345.1.
AJ416345 Genomic DNA. Translation: CAC95176.1.
AM040708 Genomic DNA. Translation: CAJ13580.1.
RefSeqiWP_032489926.1. NG_049043.1.

Genome annotation databases

KEGGiag:AAF05311.

Similar proteinsi

Entry informationi

Entry nameiQ9L5C8_ECOLX
AccessioniPrimary (citable) accession number: Q9L5C8
Secondary accession number(s): Q9RP34
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, PlasmidImported