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Q9L560 (PGK_BRUAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase
EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:BruAb1_1714
OrganismBrucella abortus biovar 1 (strain 9-941) [Complete proteome] [HAMAP]
Taxonomic identifier262698 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella ›

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Sequence caution

The sequence AAX75033.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145915

Regions

Nucleotide binding353 – 3564ATP By similarity
Region21 – 233Substrate binding By similarity
Region59 – 624Substrate binding By similarity

Sites

Binding site361Substrate By similarity
Binding site1181Substrate By similarity
Binding site1511Substrate By similarity
Binding site2011ATP By similarity
Binding site3231ATP By similarity

Experimental info

Sequence conflict1011A → P in AAF71544. Ref.1
Sequence conflict1611H → N in AAF71544. Ref.1
Sequence conflict3251R → S in AAF71544. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9L560 [UniParc].

Last modified June 21, 2005. Version 2.
Checksum: 1A5F9D738ACDCF89

FASTA39641,796
        10         20         30         40         50         60 
MMFRTLDDAN VQSKRVLVRV DLNVPMANGE VTDLTRIERI VPTIAELSRK GAKVILLAHF 

        70         80         90        100        110        120 
GRPKGVASDE NSLKHVVKPL SKVLDHSVHF AEDCIGDKAK AAVDALKDGD VLLLENTRFH 

       130        140        150        160        170        180 
KGEEKNDPEF VQALAANGDL YVNDAFSAAH RAHASTEGLA HVLPAFAGRA MQAELEALEK 

       190        200        210        220        230        240 
GLGNPARPVV AIVGGAKVST KLDLLSNLIE KVDALVIGGG MANTFLAAKG LDVGKSLCEH 

       250        260        270        280        290        300 
ELASTAREIM AKAETTKCAI ILPVDAVVGW HFAADTPHQT YGVDSVPGDA MILDAGELST 

       310        320        330        340        350        360 
DLIASAIDDA ATLVWNGPLG AFELRPFDTA TVKVARHVAK RTKEGKLVSV GGGGDTVAAL 

       370        380        390 
NHAGVADDFT YISTAGGAFL EWMEGKPLPG VDVLKK

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and DNA sequence analysis of the phosphoglycerate kinase (pgk) from Brucella abortus."
Rosinha G.M.S., Miyoshi A., Azevedo V., Campos E., Neto E.D., Oliveira S.C.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 9-941.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF256214 Genomic DNA. Translation: AAF71544.1.
AE017223 Genomic DNA. Translation: AAX75033.1. Different initiation.
RefSeqYP_222394.1. NC_006932.1.

3D structure databases

ProteinModelPortalQ9L560.
SMRQ9L560. Positions 1-396.
ModBaseSearch...

Protein-protein interaction databases

STRING262698.BruAb1_1714.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAX75033; AAX75033; BruAb1_1714.
GeneID3340208.
KEGGbmb:BruAb1_1714.
PATRIC17825210. VBIBruAbo15061_1807.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMAKFGLADK.
ProtClustDBPRK00073.

Enzyme and pathway databases

BioCycBABO262698:GJC2-1754-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. PGK. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_BRUAB
AccessionPrimary (citable) accession number: Q9L560
Secondary accession number(s): Q57BF1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: June 21, 2005
Last modified: May 1, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Brucella abortus strain 9-941

Brucella abortus (strain 9-941): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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