Q9L4X2 (Q9L4X2_9ACTO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
NysJ EMBL AAF71767.1

Gene names

Name:

nysJ EMBL AAF71767.1

Organism

Streptomyces noursei EMBL AAF71767.1

Taxonomic identifier

1971 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	5435 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	Phosphopantetheine RuleBase RU000721
Molecular function	Transferase RuleBase RU000693
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9L4X2 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: AA55465DF087A38C	FASTA	5,435	562,677
	10 20 30 40 50 60 MNAPENPETP ENNVVAALRA AVKETDRLRR QNRMLVAAAK EPIAVVGMAC RFPGAVDSPE 70 80 90 100 110 120 ALWEMVATGT DVISGFPDDR GWDLEALRNS GTDARDTDVS QRGGFLDCIA DFDPGFFGIS 130 140 150 160 170 180 PREAVTMDPQ QRLLLTTAWE AVERAGIDAT TLRATRTGAF IGTNGQDYAY LLVRSLDDAT 190 200 210 220 230 240 GDVGTGIAAS AASGRLSYTL GLEGPALTVD TACSSSLVAL HLAVQALRNG ECGMALAGGV 250 260 270 280 290 300 NVMATPGSLV EFSRQGGLAR DGRCKAFADA ADGTGWSEGA GVLLLERLSD AQRNGHPVLA 310 320 330 340 350 360 VVRGSAVNQD GASNGFTAPN GPSQQRVIRQ ALANAGLATG DIDAVEAHGT GTPLGDPIEA 370 380 390 400 410 420 QSILATYGQD RAHPVLLGSI KSNMGHTQAA SGVAGVIKMI MAMRHGVLPR TLHVDRPSTH 430 440 450 460 470 480 VDWTTGSVEL LTDAHPWPET GRPRRTGISS FGVSGTNAHV IVEQAPDTPA EAADDTPPRT 490 500 510 520 530 540 PRTLPWLLSA RTGAALRDQA TALLDHLDRP DGDRGPTALD TAFSLATTRA ALEHRLAVVT 550 560 570 580 590 600 GTDGTAGRDA LTAWLAHGTA PDAHEGHAAG RTRCAALFSG QGAQRLGMGR ELHARFPVFA 610 620 630 640 650 660 RALDTAVDLL DAELGGTLRE VIWGTDDAPL NETGFTQPAL FAVEVALYRL IESWGVAPDF 670 680 690 700 710 720 VAGHSIGEIA AAHVAGVFSL EDACTLVAAR AGLMQALPRG GAMVAVEATE DEVSPLLTDG 730 740 750 760 770 780 VAIAAINGPT SLVVSGDETA TLAVAARLAE QGRRTTRLRV SHAFHSPLMD PMLAEFRAVA 790 800 810 820 830 840 EGLSYGEPQI PVVSNLTGAV ADGTLLGTAD YWVRHVREAV RFADGIRALT DAGVGAFLEL 850 860 870 880 890 900 GPDGTLAALA QQSAPDAVSV PVLRKDRDEE PAAVAALARL HTAGVPVDWT AFYAGTGAHR 910 920 930 940 950 960 TDLPTYAFQY ERYWPKATYR PADATGLGLT AADHPLLGAA MSVAGSDELL LTGTLSLATH 970 980 990 1000 1010 1020 PWLADHVVGG MVFFPGTGFL ELAVRAADQV GCDRVEELML AAPLILPATG TVQMQIAVGA 1030 1040 1050 1060 1070 1080 ADDDGGRDLR FFTRPGDDPD AAWAQHATGR ITEGERVLAL DTTTWPPRDA EPVDIDGLYD 1090 1100 1110 1120 1130 1140 RYRANGLDYG PVFRGLRAVW RRDTEIYAEV ALPEGTADAD AFGLHPALFD AVLHSTLFAS 1150 1160 1170 1180 1190 1200 ADGDDRSLLP FAWNGVSLHA AGADALRVRI TSCGPDAVEI TAVDPQGRPV VSVESLTLRA 1210 1220 1230 1240 1250 1260 AGPDAGTADH RADAGSLFRM DWTPRTVHAP ATPATWAVLG TDPIGLTEAL TAAGPDTVTG 1270 1280 1290 1300 1310 1320 LRDGVDALGE LTAGDDRPVP DVVAVPLRGA TDHGPAGAHD LTRTVLALLQ EWLAEERFAR 1330 1340 1350 1360 1370 1380 SRLLLVTRGA VADGERGPLD LAAAPVWGLV RSAQSENPGR LLLVDLDDTA ESAAQLPLLP 1390 1400 1410 1420 1430 1440 ALLDADEPQA VVREGTVRVG RLARLDSGRG LVPPPGTPWR LGSRAKGSLD GLALLPHPEA 1450 1460 1470 1480 1490 1500 RRPLTGHEVR VGIRAAGLNF RDVLNALGMY PGDAGLFGSE AAGVVVEVGP EVTGLAPGDR 1510 1520 1530 1540 1550 1560 VMGMLFGGFG PLGIADARLL TPVPADWSWE TGASVPLVFL TAYYALKELG GLRAGEKVLV 1570 1580 1590 1600 1610 1620 HAGAGGVGMA AIQIARHVGA EVFATASEGK WDVLRSLGVA DDHIASSRTL DFEAAFAEVA 1630 1640 1650 1660 1670 1680 GDRGLDVVLN ALSGEFVDAS MRLLGDGGRF LEMGKTDIRA ADSVPDGLSY HSFDLGMVDP 1690 1700 1710 1720 1730 1740 EHIQRMLLDL VELFDRGALA ALPVRSWDVR RAGEAFRFMS LAQHIGKIVL TVPQPLDPDG 1750 1760 1770 1780 1790 1800 TVLLTGGTGG LAGLLARHLV TEHGARHLLL AGRRGPDAPG AAALHAELTA LGAEVTVAAC 1810 1820 1830 1840 1850 1860 DVADRTALAA LLATVPAEHP LTAVVHTAGV LDDGTLTALN PDRLATVLRP KVDAAWHLHD 1870 1880 1890 1900 1910 1920 LTRHLDLAAF VLYSSTAGVM GGPGQANYAA GNTFLDALAA HRHALGLPAT SLAWGAWEQG 1930 1940 1950 1960 1970 1980 AGMTGALTDH DLRRVSDAGG QPLLTAERGL ALYDAATAAD EPLIVPLGLT GGALPAGVGV 1990 2000 2010 2020 2030 2040 PAVLRGLVRT AGRRARAGTA GVSRAGLAER LAALPEEERT PFLVELVRTE AATVLGHGST 2050 2060 2070 2080 2090 2100 DPVDARREFR QLGFDSLTAI ELRNRLGKAT GLTLPATLIF DYPTPDRLAV HLHDELLGAD 2110 2120 2130 2140 2150 2160 APVTVTAAAQ AADPEHDPVV IVGMSCRFPG GVSSPEELWD LVASGTDAIT GFPADRAWDR 2170 2180 2190 2200 2210 2220 HPQLAGAPGA RTGQGGFLRD IADFDAAFFG ISPREALAMD PQQRILLEVA WEAAERAGID 2230 2240 2250 2260 2270 2280 PQTLRGSDTG VFMGVSGQDY AGLVMRSRDD IAGHATTGLA VSVVSGRLAY ALGLEGPALS 2290 2300 2310 2320 2330 2340 VDTACSSSLV SLHLAAQALR AGECTMALAG GVTVMTTAAN FTGFSRMGGL AQDGRCKAFS 2350 2360 2370 2380 2390 2400 DSADGTGWSE GAAVLVLERL SDARRAGHRV LAVVRGSAVN QDGASNGLTA PNGPAQQRVI 2410 2420 2430 2440 2450 2460 RQALANAGLT PVDVDAVEAH GTGTPLGDPI EAQALIAAYG TDRDPEHPLL LGSVKSNIGH 2470 2480 2490 2500 2510 2520 TQSAAGAAGL VKMVMAMRHG ILPQTLHLTE PSSHVDWSAG TVRLLTERTA WPRTDRPRRA 2530 2540 2550 2560 2570 2580 GVSSFGISGT NAHVILEQPP AEPTPAADPG RPAPTVVAWP VSAQTPAALD AQLDRLRTAA 2590 2600 2610 2620 2630 2640 ALAPLDTAHT LATGRSLFEH RAVLLATVGD PATGAPDLPE VARGAATPHR TAFLFSGQGA 2650 2660 2670 2680 2690 2700 QRSGMGRELH AAFPVFAAAF DEVVAVLDAE LGSDADGGVS LREVMWGGGS ELLDRTRFTQ 2710 2720 2730 2740 2750 2760 PALFAVEVAL FRLVASWGVG PEFVAGHSVG EIAAAHVAGV FSLVDACRLV VARASLMDAL 2770 2780 2790 2800 2810 2820 PVGGVMVAVE AAEAEVVPLL VDGVAIAAVN GPVSVVVSGV EAAVGQVVDQ LVERGRRVRR 2830 2840 2850 2860 2870 2880 LAVSHAFHSP LMDPMLDAFR AVAEGLEYHQ PRIPVVSNVT GEVAAAEELC AADYWVRHVR 2890 2900 2910 2920 2930 2940 ATVRFADGVR TLAERGATAF LEIGPDGVLS ALARGVLPAE ALVTPTLRKD RDEESALLAG 2950 2960 2970 2980 2990 3000 LARLHVAGVT VDWSAALTGT GARGTDLPTY AFQRERYWPE LAAEPAGGGA DAADAEFWAA 3010 3020 3030 3040 3050 3060 VERADATALA AHLDIDGDQL GAVLPALSAW RTRRRTTSAT NALRHRESWE PLSLAGTPHT 3070 3080 3090 3100 3110 3120 GGVLVLVPAA ATTDPWVADV VAALGPDARR VDVPADGTDR AALAALLTEA ADDTAPTAVV 3130 3140 3150 3160 3170 3180 SLLALDETSG DDAVPAGTTA TAALVQALAD TGAPAPLWAL TRGAVAALPD EQPTAPAQAA 3190 3200 3210 3220 3230 3240 VWGLGRIAAL ELPRHWGGLV DLPADLDERT ARRLPAALAD AGDEDQLALR ATGAYGRRIT 3250 3260 3270 3280 3290 3300 PAPAPDDAPG TGWQPTGTVL ITGGTGALGR HTARWLAAHG AEHLLLLSRS GPDAPGAAEL 3310 3320 3330 3340 3350 3360 TTELTALGAR VTLVACDAAD REQLTRVLAE VPRDCPLTGV VHTAGVLDDG VLTGLTPDRF 3370 3380 3390 3400 3410 3420 ATVFRAKVAS AVLLDELTRD TDLAVFALFS SVAGAVGNPG QAGYAAANAV LDALAARRRA 3430 3440 3450 3460 3470 3480 QGLAGTSIAW GAWAGDGMAA RHTRPGAEPV GLLDPDLAVP ALARAVTEPQ PTLVLADLQQ 3490 3500 3510 3520 3530 3540 PRLLESLLAL RPSPLLSRLP AARTAARAVQ EADRRRAGAA ADLRDQLAGT APADRHAVLL 3550 3560 3570 3580 3590 3600 RLVRTTAAAV LGHTGADAIR ADKPFRDLGF DSLTAVELSS ALAAATGLAL PPSLVFDHPS 3610 3620 3630 3640 3650 3660 PRALADHLRA ELTGDRPESA PAAPPAPVPA ADDDPIVVVG MACRFPGGVT TPEEFWQLLA 3670 3680 3690 3700 3710 3720 EGRDGIDAFP TDRGWDLDVL GRRRPGPQRP PRSAASSYDA AAFDPGFFDI SPREALAMDP 3730 3740 3750 3760 3770 3780 QQRLLLETAW EAVERTGTDP TRLRGSRTGV FVGTNGQDYA GLVLRAQEDV EGHAGTGLAA 3790 3800 3810 3820 3830 3840 SVISGRLAYA FGFEGPAVTV DTACSSSLVA LHWAVQALRA GECSLALAGG VTVMTTSTSF 3850 3860 3870 3880 3890 3900 AGFTRQGGLA PDGHCKAFSD SADGTGWSEG VGVLVVERRS DALRNGHEIL AVVRGSAVNQ 3910 3920 3930 3940 3950 3960 DGASNGLTAP NGPAQQRVIR QALANAGLAP GDVDAVEAHG TGTVLGDPIE AQALLATYGQ 3970 3980 3990 4000 4010 4020 DRPADRPLWL GSVKSNIGHT QAAAGAAGLM KMVLALQHGT LPRTLHVTEP STRVDWSAGA 4030 4040 4050 4060 4070 4080 VRLLTERTVW PRTDRPRRAG VSSFGISGTN AHVILEQPPA EPTPTAPADR PTRTPAVLPW 4090 4100 4110 4120 4130 4140 VVSARSATAL DAQLARLRAF AAERPDLPPA DVAHSLVTSR ATFEHRAVLL AAPDGITAAA 4150 4160 4170 4180 4190 4200 RAEARERSTA FLFSGQGAQR SGMGRELHAA FPVFAAAFDE VVAVLDAELA TGSGGGVSLR 4210 4220 4230 4240 4250 4260 EVMWGGGSEL LDRTRFTQPA LFAVEVALFR LVASWGVGPE FVAGHSVGEI AAAYVAGVFS 4270 4280 4290 4300 4310 4320 LVDACRLVVA RASLMDALPV GGVMVAVEAA EAEVVPLLVD GVAIAAVNGP VSVVVSGVEA 4330 4340 4350 4360 4370 4380 AVGQVVDQLV ERGRRVRRLA VSHAFHSPLM DPMLDAFRAV AEGLEYHQPR IPVVSNVTGE 4390 4400 4410 4420 4430 4440 VAAAEELCAA DYWVRHVRAT VRFADGVRTL AERGATAFLE IGPDGVLSAL AAACLFDTDA 4450 4460 4470 4480 4490 4500 EVVPALRKGR PEEHTALTAA AQLHVAGVDI DWTAVLAGTG GRRIALPTYA FQRERYWPSL 4510 4520 4530 4540 4550 4560 AAQAPGDAGG LGLEAGRHPL LGAATTVAGS AEILLTGRLS TTAQPWLAVY EADGRTVLPA 4570 4580 4590 4600 4610 4620 AVLAELAVRA GDQADCPTVA ELTVAAPLVL TGAAAQRLQV RVAAPDDTGR RALSVHARPD 4630 4640 4650 4660 4670 4680 DSPDSPWTLH ATAVLTHDTP QPPAPDTGWP PERAVPLDAL PTATGPARIA AAWQWGDELC 4690 4700 4710 4720 4730 4740 AEIELPEPGP AERAFALHPA LLDTAVRAGG LLDGDATLDA LGWRGLALHA ASATALRVRL 4750 4760 4770 4780 4790 4800 TPDGTDTWAL EATDPQGAPV VSVTGLTLGT PTVDRSGAGA ADDGATLLDL EWVPAPQAAP 4810 4820 4830 4840 4850 4860 TGGDHLPYAV LGDQLAELDG QLRIAGDGPG RVASLAALLD GGAPLPRLVL APVLGVPTGE 4870 4880 4890 4900 4910 4920 GDLPAAVRGT TTAVLELLQR WTADARTADS HLVIVTRGAV AAGAEDVHDL AAAPVWGLVR 4930 4940 4950 4960 4970 4980 SAQSEHPGSF LLLDLDPADP AGASRAAAPA TLAALLDAGE TQAAVRADTL TVARLTRAAD 4990 5000 5010 5020 5030 5040 GPEATAGHPV RDWDRDGTVL ITGGTGGLGG LLARHLVTGH GIKHLLLAGR RGPDAPGARA 5050 5060 5070 5080 5090 5100 LRDELAALGA EVTVAACDVA DRAALDRLLA QLPPEHPLTA VVHTAGVLDD ATVGTLTPER 5110 5120 5130 5140 5150 5160 LDTVLRAKAD AAWHLHDATR DRDLAGFVLY SSVAGVTGGP GQGNYAAGNT FLDALAAHRA 5170 5180 5190 5200 5210 5220 AQGLPGLSLA WGPWGQDAGM TGTLGAADLA RLERSGMPPL TPEQGLALFD AAGARGDGFA 5230 5240 5250 5260 5270 5280 VAVRLARGAA APGADEVPAV LRALVRGRRR TAAAAGHAGV LARRLAALDA EQRHQALLDL 5290 5300 5310 5320 5330 5340 VRTETAAVLG HSGADAVPAE RDFNRLGFDS LMAVELRTRL ATATGARLPA TLVFDHPTPD 5350 5360 5370 5380 5390 5400 AVARHLASTL PGGTAAGPDR SPLAELDRIA AELSPEGADD ATRQGVVGRL RHLLAQWDGT 5410 5420 5430 RQDGGGTTVD DRIEAASAEE VLAFIDHELG RQADS

References

[1]	"Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway." Brautaset T., Sekurova O.N., Sletta H., Ellingsen T.E., StrLm A.R., Valla S., Zotchev S.B. Chem. Biol. 7:395-403(2000) [PubMed: 10873841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC 11455 EMBL AAF71767.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF263912 Genomic DNA. Translation: AAF71767.1.
3D structure databases
HSSP	HSSP built from PDB template 1PQW based on UniProtKB P96202.
ProteinModelPortal	Q9L4X2.
SMR	Q9L4X2. Positions 2005-2096, 3523-3612.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001227. Ac_transferase_dom. IPR009081. Acyl_carrier_prot-like. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR000794. Beta-ketoacyl_synthase. IPR002198. DH_sc/Rdtase_SDR. IPR011032. GroES-like. IPR018201. Ketoacyl_synth_AS. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016036. Malonyl_transacylase_ACP-bd. IPR016040. NAD(P)-bd_dom. IPR006163. Phsphopanteth-bd. IPR020842. PKS/FAS_KR. IPR020801. PKS_acyl_transferase. IPR020841. PKS_Beta-ketoAc_synthase_dom. IPR020807. PKS_dehydratase. IPR020843. PKS_ER. IPR013968. PKS_KR. IPR020806. PKS_PP-bd. IPR006162. PPantetheine_attach_site. IPR002364. Quin_OxRdtase/zeta-crystal_CS. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.366.10. Ac_transferase_reg. 6 hits. G3DSA:1.10.1200.10. ACP_like. 3 hits. G3DSA:3.40.50.720. NAD(P)-bd. 4 hits. G3DSA:3.40.47.10. Thiolase-like_subgr. 6 hits.
PANTHER	PTHR11712. Ketoacyl_synth. 1 hit.
Pfam	PF00698. Acyl_transf_1. 3 hits. PF08240. ADH_N. 1 hit. PF00106. adh_short. 1 hit. PF00107. ADH_zinc_N. 1 hit. PF00109. ketoacyl-synt. 3 hits. PF02801. Ketoacyl-synt_C. 3 hits. PF08659. KR. 2 hits. PF00550. PP-binding. 3 hits. [Graphical view]
SMART	SM00827. PKS_AT. 3 hits. SM00826. PKS_DH. 2 hits. SM00829. PKS_ER. 1 hit. SM00822. PKS_KR. 3 hits. SM00825. PKS_KS. 3 hits. SM00823. PKS_PP. 3 hits. [Graphical view]
SUPFAM	SSF47336. ACP_like. 3 hits. SSF52151. Acyl_Trfase/lysoPlipase. 3 hits. SSF50129. GroES_like. 1 hit. SSF55048. Malonyl_transacylase_ACP-bd. 3 hits. SSF53901. Thiolase-like. 3 hits.
PROSITE	PS50075. ACP_DOMAIN. 3 hits. PS00606. B_KETOACYL_SYNTHASE. 3 hits. PS00012. PHOSPHOPANTETHEINE. 3 hits. PS01162. QOR_ZETA_CRYSTAL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9L4X2_9ACTO

Accession

Primary (citable) accession number: Q9L4X2

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	December 14, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)