Q9L4X1 (Q9L4X1_9ACTO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
NysK EMBL AAF71768.1

Gene names

Name:

nysK EMBL AAF71768.1

Organism

Streptomyces noursei EMBL AAF71768.1

Taxonomic identifier

1971 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	2066 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	Phosphopantetheine RuleBase RU000721
Molecular function	Transferase RuleBase RU000693
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9L4X1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: CB02F5991FB2B56E	FASTA	2,066	214,573
	10 20 30 40 50 60 MPDEKKLVDY LKWVTKDLHQ TRQRLQEVEA GRHEPVAIVG MACRFPGGVR SPEDLWELLS 70 80 90 100 110 120 AGRDGIGPFP ADRGWDLAAL AGDGPGRSAT QEGGFLPDAA AFDPGFFDIS PREALAMDPQ 130 140 150 160 170 180 QRLLLETAWE AVERSGIDPA GLRGSRTGVF VGTNGQDYAH LVLAAQDDMG GYAGNGLAAS 190 200 210 220 230 240 VLSGRLAFAL GLEGPAVTLD TACSSSLVTL HLAAQAVRAG ECGLALAGGV TVMTTSSSFA 250 260 270 280 290 300 GFSLQGGLAP DGRCKAFAEA ADGTGWSEGI GLLLVERLSD AQRNGHPVLA VLRGSAVNQD 310 320 330 340 350 360 GASNGLSAPN GPSQQRVIRQ ALAGAGLVPG DVDAVEAHGT GTRLGDPIEA GALLATYGQD 370 380 390 400 410 420 RPADRPLWLG SVKSNLGHTQ AAAGVAGVIK MVLALRHGVL PQTLHVDAPS SHVDWESGAV 430 440 450 460 470 480 RLLTAPVAWS EGDDRVRRAG VSSFGISGTN AHVILEQAPD QPEPTAEETA AAAPGGTAEE 490 500 510 520 530 540 RAAAPVAPRA VPWPVAARTA GALDAQLVRV RALTTAPGRT AADVGHALAT ARTPFEHRAL 550 560 570 580 590 600 LVHEGGAVTE VARGAVPTGD RGGLAVLFSG QGSQRPGMGR ELHARYPVFA AAFDETVALL 610 620 630 640 650 660 DARLGTSLRD IVWDQDRTRL DDTRHTQPAL FAVEVALYRL LASWGIRPDH VTGHSIGEIT 670 680 690 700 710 720 AAHVAGVLTL ADACTLVAAR ATAMSELPPG GAMVALEATE DEVRPLLTDD LAIAAVNAPR 730 740 750 760 770 780 SVVVAGAEDA ALAVRRHFDD LGRRTTRLPV SHAFHSPLMD PMLDAFRTAL APLTFAEPEI 790 800 810 820 830 840 PVVSNLTGLP ATAEELATPH YWVCHVRQAV RFGDGVRALA DRGVRTFLEL GPDGVLSALV 850 860 870 880 890 900 RENLPEPGLV AVPVLRKERP EETTVLAALG TLWAHGADVD WDAVFAGTRT PQADPVELPT 910 920 930 940 950 960 YAFQRARYWP TLGARHGDPA DLGQTAAAHP LLGAAVTLAD ADETVLTGRL ALPSHPWLGD 970 980 990 1000 1010 1020 HRSDGRITVP GVAFAELAVR AGDLSGTPHL ARLDLPAPLT LGDGDTVTLQ VRVGAPDPAG 1030 1040 1050 1060 1070 1080 HRPLTVHARL AATEDAPWTT CATGLLAPDA PEAPADPIGP ADAGWPPRDA RPVPVADLDA 1090 1100 1110 1120 1130 1140 AATAAGRHYG PHFQGLTGLW RRDGEVFAEV ALPTATAADR AFGIHPALLA TALRATAALD 1150 1160 1170 1180 1190 1200 DDHTAGHTPE PTGITGLALH ATGATALRVR LTATGPDTVA LAAADATGGA VLTADTVTLG 1210 1220 1230 1240 1250 1260 SPQDRPAPAP AGHTGQGGLF HLDWVPVDPG SRATGTRWAV VGDDELDLGY ALHRADETVS 1270 1280 1290 1300 1310 1320 AYAASLGGAI GDSGLAPDVF LVPVVGGPDA GPDAVHAVTA RALGLLQEWL NEPRLAGARL 1330 1340 1350 1360 1370 1380 VFVTRGAVAV PGETVTDPAG AAVWGLLRSA QTENPGSLLL VDLDDAFRSA GMLPHVLTLD 1390 1400 1410 1420 1430 1440 EQQLVVRDHA VRAARLARLP EPAAGTAPAR AWDPDGTVLI TGGTGGLGAA LARHLVTVRG 1450 1460 1470 1480 1490 1500 ARHLLLAGRR GPEAPGAGEL VAELTAQGAD VRVAACDVGD RTALDALLAT VPAAHPLTAV 1510 1520 1530 1540 1550 1560 VHTAGVLDDA LIGSLTPDQL ATVLRPKADA AWHLHDATRG LDLAGFVLYS SVSGVLGSPG 1570 1580 1590 1600 1610 1620 QGNYAAANAY LDALARHRAD QGLPALSLAW GPWGRGSGMT ASVSDADLER MARGGLPPLT 1630 1640 1650 1660 1670 1680 VEDGLALFDA AVGRPEPALV PSRINVAGLR DQQALPALWR DLVPRARRTA ATADRSPVTV 1690 1700 1710 1720 1730 1740 RERLRHLDET GQEQLLIDLV VGYTAGLLGH PDPTAVDPER GFLELGFDSL VSVGLRNQLA 1750 1760 1770 1780 1790 1800 EILGLRLPSS IVFDSKSPVK LARWLHQELA NGPQPGATGP AAADARPAVR SDDTLEGLFY 1810 1820 1830 1840 1850 1860 NAVRGGKLVE AMRMLKAVAN TRPMFDTPAE LEELSEPVTL ADGPGRPRLI FVSAPGATGG 1870 1880 1890 1900 1910 1920 VHQYARIAAH FRGSRHVSAL PLMGFAPGEL LPATSEAAAR IVAESVLMAS EGEPFVMVGH 1930 1940 1950 1960 1970 1980 STGGSLAYLA AGVLEDTWDV RPEAVVLLDT ASIRYNPGEG NDLDRTTRFY LADIDSPSVT 1990 2000 2010 2020 2030 2040 LNSARMSAMA HWFMAMTDIQ APAPTAPTLL VRAARALDGF RLDTSSVPAD EVRDIDADHL 2050 2060 SLAKEHSALT AQAIEGWLAE LPDPAA

References

[1]	"Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway." Brautaset T., Sekurova O.N., Sletta H., Ellingsen T.E., StrLm A.R., Valla S., Zotchev S.B. Chem. Biol. 7:395-403(2000) [PubMed: 10873841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC 11455 EMBL AAF71768.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF263912 Genomic DNA. Translation: AAF71768.1.
3D structure databases
HSSP	HSSP built from PDB template 1MLA based on UniProtKB P25715.
ProteinModelPortal	Q9L4X1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001227. Ac_transferase_dom. IPR009081. Acyl_carrier_prot-like. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR000794. Beta-ketoacyl_synthase. IPR002198. DH_sc/Rdtase_SDR. IPR018201. Ketoacyl_synth_AS. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016036. Malonyl_transacylase_ACP-bd. IPR016040. NAD(P)-bd_dom. IPR006163. Phsphopanteth-bd. IPR020842. PKS/FAS_KR. IPR020801. PKS_acyl_transferase. IPR020841. PKS_Beta-ketoAc_synthase_dom. IPR020807. PKS_dehydratase. IPR020806. PKS_PP-bd. IPR020802. PKS_thioesterase. IPR015083. Polyketide_synth_docking. IPR006162. PPantetheine_attach_site. IPR001031. Thioesterase. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.366.10. Ac_transferase_reg. 2 hits. G3DSA:1.10.1200.10. ACP_like. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
PANTHER	PTHR11712. Ketoacyl_synth. 1 hit.
Pfam	PF00698. Acyl_transf_1. 1 hit. PF00106. adh_short. 1 hit. PF08990. Docking. 1 hit. PF00109. ketoacyl-synt. 1 hit. PF02801. Ketoacyl-synt_C. 1 hit. PF00550. PP-binding. 1 hit. PF00975. Thioesterase. 1 hit. [Graphical view]
SMART	SM00827. PKS_AT. 1 hit. SM00826. PKS_DH. 1 hit. SM00822. PKS_KR. 1 hit. SM00825. PKS_KS. 1 hit. SM00823. PKS_PP. 1 hit. SM00824. PKS_TE. 1 hit. [Graphical view]
SUPFAM	SSF47336. ACP_like. 1 hit. SSF52151. Acyl_Trfase/lysoPlipase. 1 hit. SSF55048. Malonyl_transacylase_ACP-bd. 1 hit. SSF53901. Thiolase-like. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00606. B_KETOACYL_SYNTHASE. 1 hit. PS00012. PHOSPHOPANTETHEINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9L4X1_9ACTO

Accession

Primary (citable) accession number: Q9L4X1

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	December 14, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)