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Q9L4T0

- LUXS_SALTY

UniProt

Q9L4T0 - LUXS_SALTY

Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity.By similarity

    Catalytic activityi

    S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.

    Cofactori

    Binds 1 iron ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi54 – 541IronBy similarity
    Metal bindingi58 – 581IronBy similarity
    Metal bindingi128 – 1281IronBy similarity

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. quorum sensing Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Autoinducer synthesis, Quorum sensing

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-2834-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    S-ribosylhomocysteine lyase (EC:4.4.1.21)
    Alternative name(s):
    AI-2 synthesis protein
    Autoinducer-2 production protein LuxS
    Gene namesi
    Name:luxS
    Ordered Locus Names:STM2817
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 171170S-ribosylhomocysteine lyasePRO_0000172249Add
    BLAST

    Proteomic databases

    PaxDbiQ9L4T0.
    PRIDEiQ9L4T0.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi99287.STM2817.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9L4T0.
    SMRiQ9L4T0. Positions 3-161.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LuxS family.Curated

    Phylogenomic databases

    eggNOGiCOG1854.
    HOGENOMiHOG000040371.
    KOiK07173.
    OMAiRDHLNSD.
    OrthoDBiEOG68WRBM.
    PhylomeDBiQ9L4T0.

    Family and domain databases

    Gene3Di3.30.1360.80. 1 hit.
    HAMAPiMF_00091. LuxS.
    InterProiIPR011249. Metalloenz_LuxS/M16.
    IPR003815. S-ribosylhomocysteinase.
    [Graphical view]
    PfamiPF02664. LuxS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006160. AI2. 1 hit.
    PRINTSiPR01487. LUXSPROTEIN.
    ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF63411. SSF63411. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9L4T0-1 [UniParc]FASTAAdd to Basket

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    MPLLDSFAVD HTRMQAPAVR VAKTMNTPHG DAITVFDLRF CIPNKEVMPE    50
    KGIHTLEHLF AGFMRDHLNG NGVEIIDISP MGCRTGFYMS LIGTPDEQRV 100
    ADAWKAAMAD VLKVQDQNQI PELNVYQCGT YQMHSLSEAQ DIARHILERD 150
    VRVNSNKELA LPKEKLQELH I 171
    Length:171
    Mass (Da):19,308
    Last modified:January 23, 2007 - v3
    Checksum:i359A88331FF56CDF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF268390 Genomic DNA. Translation: AAF73475.1.
    AE006468 Genomic DNA. Translation: AAL21702.1.
    RefSeqiNP_461743.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL21702; AAL21702; STM2817.
    GeneIDi1254340.
    KEGGistm:STM2817.
    PATRICi32384316. VBISalEnt20916_2975.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF268390 Genomic DNA. Translation: AAF73475.1 .
    AE006468 Genomic DNA. Translation: AAL21702.1 .
    RefSeqi NP_461743.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali Q9L4T0.
    SMRi Q9L4T0. Positions 3-161.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM2817.

    Proteomic databases

    PaxDbi Q9L4T0.
    PRIDEi Q9L4T0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL21702 ; AAL21702 ; STM2817 .
    GeneIDi 1254340.
    KEGGi stm:STM2817.
    PATRICi 32384316. VBISalEnt20916_2975.

    Phylogenomic databases

    eggNOGi COG1854.
    HOGENOMi HOG000040371.
    KOi K07173.
    OMAi RDHLNSD.
    OrthoDBi EOG68WRBM.
    PhylomeDBi Q9L4T0.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-2834-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1360.80. 1 hit.
    HAMAPi MF_00091. LuxS.
    InterProi IPR011249. Metalloenz_LuxS/M16.
    IPR003815. S-ribosylhomocysteinase.
    [Graphical view ]
    Pfami PF02664. LuxS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006160. AI2. 1 hit.
    PRINTSi PR01487. LUXSPROTEIN.
    ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF63411. SSF63411. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Salmonella typhimurium luxS gene."
      Rychlik I., Sevcik M., Sebkova A., Volf J.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiLUXS_SALTY
    AccessioniPrimary (citable) accession number: Q9L4T0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3