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Q9L4K1

- BETB_CHRSD

UniProt

Q9L4K1 - BETB_CHRSD

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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

K(+)UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi93 – 931Potassium 1UniRule annotation
Active sitei162 – 1621Charge relay systemUniRule annotation
Metal bindingi180 – 1801Potassium 1; via carbonyl oxygenUniRule annotation
Binding sitei209 – 2091NAD/NADP; via amide nitrogenUniRule annotation
Metal bindingi245 – 2451Potassium 2; via carbonyl oxygenUniRule annotation
Sitei247 – 2471Seems to be a necessary countercharge to the potassium cationsUniRule annotation
Active sitei251 – 2511Proton acceptorUniRule annotation
Binding sitei285 – 2851NAD/NADPUniRule annotation
Binding sitei386 – 3861NAD/NADPUniRule annotation
Metal bindingi456 – 4561Potassium 2; via carbonyl oxygenUniRule annotation
Metal bindingi459 – 4591Potassium 2; via carbonyl oxygenUniRule annotation
Active sitei463 – 4631Charge relay systemUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi150 – 1534NAD/NADPUniRule annotation
Nucleotide bindingi176 – 1794NAD/NADPUniRule annotation
Nucleotide bindingi228 – 2336NAD/NADPUniRule annotation

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betBUniRule annotation
OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Taxonomic identifieri290398 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 489489NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_0000056545Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei285 – 2851Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9L4K1.
SMRiQ9L4K1. Positions 8-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9L4K1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAQSAQPLY IGGRPVDATS GETFTVTNPY DGSLLATIGQ ASQADVDSAV
60 70 80 90 100
QAAQRGQREW AAMTGMERSR ILLRAVALLR ERNDELAELE TRNTGKPISE
110 120 130 140 150
TASVDIVTGA DALEYYAGLA PAIEGSQIPL RDTRLVYTRR EPLGVIGAIG
160 170 180 190 200
AWNYPIQIAC WKAAPALAAG NAIVFKPSEV TPLTALKLAE IFTEAGLPDG
210 220 230 240 250
VFNVVQGDGR VGAMLTEHEG IAKVSFTGEV GTGKKVMAAA GGSTLKDVTM
260 270 280 290 300
ELGGKSPLIV FADADLDRAA DAAMMANFYS SGQICTNGTR VFVERSAKEA
310 320 330 340 350
FEAKLVERVA RIKAGDPMDP SVNFGPLVSF EHQEKVLSYI ALGKEQGARV
360 370 380 390 400
LAGGDAWNSG EWAKGAWAAP TVFTDCTDEM RVVKEEIFGP VMSVLAFDDE
410 420 430 440 450
EEVIRRANNT KYGLAAGVFS ESLNRAHRVI HQLEAGICWI NTWGESPSEM
460 470 480
PVGGYKESGI GRENGVETLN HYTQTKSVQI EMGPFESVF
Length:489
Mass (Da):52,333
Last modified:October 1, 2000 - v1
Checksum:i42AFE892DA57DD4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238780 Genomic DNA. Translation: CAB77175.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238780 Genomic DNA. Translation: CAB77175.1 .

3D structure databases

ProteinModelPortali Q9L4K1.
SMRi Q9L4K1. Positions 8-489.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genes for the synthesis of the osmoprotectant glycine betaine from choline in the moderately halophilic bacterium Halomonas elongata DSM 3043."
    Canovas D., Vargas C., Kneip S., Moron M.J., Ventosa A., Bremer E., Nieto J.J.
    Microbiology 146:455-463(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiBETB_CHRSD
AccessioniPrimary (citable) accession number: Q9L4K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3