Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

K+UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi93Potassium 1UniRule annotation1
Active sitei162Charge relay systemUniRule annotation1
Metal bindingi180Potassium 1; via carbonyl oxygenUniRule annotation1
Binding sitei209NAD/NADP; via amide nitrogenUniRule annotation1
Metal bindingi245Potassium 2; via carbonyl oxygenUniRule annotation1
Sitei247Seems to be a necessary countercharge to the potassium cationsUniRule annotation1
Active sitei251Proton acceptorUniRule annotation1
Binding sitei285NAD/NADPUniRule annotation1
Binding sitei386NAD/NADPUniRule annotation1
Metal bindingi456Potassium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi459Potassium 2; via carbonyl oxygenUniRule annotation1
Active sitei463Charge relay systemUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi150 – 153NAD/NADPUniRule annotation4
Nucleotide bindingi176 – 179NAD/NADPUniRule annotation4
Nucleotide bindingi228 – 233NAD/NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betBUniRule annotation
OrganismiChromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)
Taxonomic identifieri290398 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeChromohalobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000565451 – 489NAD/NADP-dependent betaine aldehyde dehydrogenaseAdd BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285Cysteine sulfenic acid (-SOH)UniRule annotation1

Keywords - PTMi

Oxidation

Proteomic databases

PRIDEiQ9L4K1

Interactioni

Subunit structurei

Dimer of dimers.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9L4K1
SMRiQ9L4K1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotation

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
HAMAPiMF_00804 BADH, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR011264 BADH
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01804 BADH, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Q9L4K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAQSAQPLY IGGRPVDATS GETFTVTNPY DGSLLATIGQ ASQADVDSAV
60 70 80 90 100
QAAQRGQREW AAMTGMERSR ILLRAVALLR ERNDELAELE TRNTGKPISE
110 120 130 140 150
TASVDIVTGA DALEYYAGLA PAIEGSQIPL RDTRLVYTRR EPLGVIGAIG
160 170 180 190 200
AWNYPIQIAC WKAAPALAAG NAIVFKPSEV TPLTALKLAE IFTEAGLPDG
210 220 230 240 250
VFNVVQGDGR VGAMLTEHEG IAKVSFTGEV GTGKKVMAAA GGSTLKDVTM
260 270 280 290 300
ELGGKSPLIV FADADLDRAA DAAMMANFYS SGQICTNGTR VFVERSAKEA
310 320 330 340 350
FEAKLVERVA RIKAGDPMDP SVNFGPLVSF EHQEKVLSYI ALGKEQGARV
360 370 380 390 400
LAGGDAWNSG EWAKGAWAAP TVFTDCTDEM RVVKEEIFGP VMSVLAFDDE
410 420 430 440 450
EEVIRRANNT KYGLAAGVFS ESLNRAHRVI HQLEAGICWI NTWGESPSEM
460 470 480
PVGGYKESGI GRENGVETLN HYTQTKSVQI EMGPFESVF
Length:489
Mass (Da):52,333
Last modified:October 1, 2000 - v1
Checksum:i42AFE892DA57DD4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238780 Genomic DNA Translation: CAB77175.1

Similar proteinsi

Entry informationi

Entry nameiBETB_CHRSD
AccessioniPrimary (citable) accession number: Q9L4K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health