Reviewed, UniProtKB/Swiss-Prot Q9L4K1 (BETB_CHRSD)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Name:

betB

Organism

Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)

Taxonomic identifier

290398 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Oceanospirillales › Halomonadaceae › Chromohalobacter

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_0000056545
Regions
	Nucleotide binding	228 – 233	6	NAD By similarity
Sites
	Active site	251	1	By similarity
	Active site	285	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9L4K1-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 42AFE892DA57DD4B	FASTA	489	52,333
	10 20 30 40 50 60 MTAQSAQPLY IGGRPVDATS GETFTVTNPY DGSLLATIGQ ASQADVDSAV QAAQRGQREW 70 80 90 100 110 120 AAMTGMERSR ILLRAVALLR ERNDELAELE TRNTGKPISE TASVDIVTGA DALEYYAGLA 130 140 150 160 170 180 PAIEGSQIPL RDTRLVYTRR EPLGVIGAIG AWNYPIQIAC WKAAPALAAG NAIVFKPSEV 190 200 210 220 230 240 TPLTALKLAE IFTEAGLPDG VFNVVQGDGR VGAMLTEHEG IAKVSFTGEV GTGKKVMAAA 250 260 270 280 290 300 GGSTLKDVTM ELGGKSPLIV FADADLDRAA DAAMMANFYS SGQICTNGTR VFVERSAKEA 310 320 330 340 350 360 FEAKLVERVA RIKAGDPMDP SVNFGPLVSF EHQEKVLSYI ALGKEQGARV LAGGDAWNSG 370 380 390 400 410 420 EWAKGAWAAP TVFTDCTDEM RVVKEEIFGP VMSVLAFDDE EEVIRRANNT KYGLAAGVFS 430 440 450 460 470 480 ESLNRAHRVI HQLEAGICWI NTWGESPSEM PVGGYKESGI GRENGVETLN HYTQTKSVQI EMGPFESVF

References

[1]

"Genes for the synthesis of the osmoprotectant glycine betaine from choline in the moderately halophilic bacterium Halomonas elongata DSM 3043." Canovas D., Vargas C., Kneip S., Moron M.J., Ventosa A., Bremer E., Nieto J.J. Microbiology 146:455-463(2000) [PubMed: 10708384] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ238780 Genomic DNA. Translation: CAB77175.1.
3D structure databases
HSSP	HSSP built from PDB template 1A4S based on UniProtKB P56533.
ModBase	Search...
Family and domain databases
HAMAP	MF_00804. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_CHRSD

Accession

Primary (citable) accession number: Q9L4K1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)