Reviewed, UniProtKB/Swiss-Prot Q9L3B2 (PQQC_GLUOX)

Names and origin

Protein names

Recommended name:
    Pyrroloquinoline-quinone synthase
    EC=1.3.3.11
Alternative name(s):
    Coenzyme PQQ synthesis protein C
    Pyrroloquinoline quinone biosynthesis protein C

Gene names

Name:	pqqC
Ordered Locus Names:	GOX0985

Organism

Gluconobacter oxydans (Gluconobacter suboxydans) [Complete proteome] [HAMAP]

Taxonomic identifier

442 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Gluconobacter

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity.
Catalytic activity	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O. HAMAP MF_00654
Pathway	Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. HAMAP MF_00654
Sequence similarities	Belongs to the pqqC family.

Ontologies

Keywords
Biological process	PQQ biosynthesis
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyrroloquinoline quinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	pyrroloquinoline-quinone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 239	239	Pyrroloquinoline-quinone synthase HAMAP MF_00654		PRO_0000219978
Experimental info
	Sequence conflict	69	1	A → D in CAB83199. Ref.1
	Sequence conflict	88 – 89	2	GT → EP in CAB83199. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9L3B2-1 [UniParc]. Last modified March 15, 2005. Version 2. Checksum: 708C883BED29C7F2	FASTA	239	27,293
	10 20 30 40 50 60 MTLLTPDQLE AQLRQIGAER YHNRHPFHRK LHDGKLDKAQ VQAWALNRYY YQARIPAKDA 70 80 90 100 110 120 TLLARLPTAE LRREWRRRIE DHDGTEPGTG GVARWLMLTD GLGLDRDYVE SLDGLLPATR 130 140 150 160 170 180 FSVDAYVNFV RDQSILAAIA SSLTELFSPT IISERVSGML RHYDFVSEKT LAYFTPRLTQ 190 200 210 220 230 APRDSDFALA YVREKARTPE QQKEVLGALE FKCSVLWTML DALDYAYVEG HIPPGAFVP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The pyrroloquinoline quinone synthesis genes of Gluconobacter oxydans." Felder M., Gupta A., Verma V., Kumar A., Qazi G.N., Cullum J. FEMS Microbiol. Lett. 193:231-236(2000) [PubMed: 11111029] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 9937 / LMG 1404 / NCIB 8084.
[2]	"Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans." Prust C., Hoffmeister M., Liesegang H., Wiezer A., Fricke W.F., Ehrenreich A., Gottschalk G., Deppenmeier U. Nat. Biotechnol. 23:195-200(2005) [PubMed: 15665824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 621H.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ277117 Genomic DNA. Translation: CAB83199.1. CP000009 Genomic DNA. Translation: AAW60757.1.
RefSeq	YP_191413.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3250200.
GenomeReviews	Gene locus GOX0985 in contig CP000009_GR.
KEGG	gox:GOX0985.
NMPDR	fig|290633.1.peg.958.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9L3B2.
OMA	AWALNRY.
Enzyme and pathway databases
BioCyc	GOXY290633:GOX0985-MON.
BRENDA	1.3.3.11. 3050.
Family and domain databases
HAMAP	MF_00654. [Tree]
InterPro	IPR016084. Haem_Oase-like_multi-hlx. IPR011845. PQQ_synth_PqqC. IPR004305. TENA/THI4/PQQ_synth_PqqC. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
Pfam	PF03070. TENA_THI-4. 1 hit. [Graphical view]
TIGRFAMs	TIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PQQC_GLUOX

Accession

Primary (citable) accession number: Q9L3B2
Secondary accession number(s): Q5FS89

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2003
Last sequence update:	March 15, 2005
Last modified:	November 3, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)