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Protein

Beta-lactamase

Gene

fox-4

Organism
Escherichia coli
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi24Zinc 1; via amide nitrogen and carbonyl oxygenCombined sources1
Metal bindingi26Zinc 1Combined sources1
Metal bindingi26Zinc 2Combined sources1
Metal bindingi60Zinc 2; via pros nitrogenCombined sources1
Metal bindingi60Zinc 3; via pros nitrogenCombined sources1
Metal bindingi105Zinc 4Combined sources1
Metal bindingi105Zinc 5Combined sources1
Metal bindingi145Zinc 6Combined sources1
Metal bindingi147Zinc 6Combined sources1
Metal bindingi147Zinc 7Combined sources1
Metal bindingi168Zinc 4; via tele nitrogenCombined sources1
Metal bindingi168Zinc 6; via tele nitrogenCombined sources1
Metal bindingi206Zinc 5; via pros nitrogenCombined sources1
Metal bindingi206Zinc 7; via pros nitrogenCombined sources1
Metal bindingi207Zinc 1; via tele nitrogenCombined sources1
Metal bindingi207Zinc 8; via tele nitrogenCombined sources1
Metal bindingi295Zinc 2Combined sources1
Metal bindingi295Zinc 3Combined sources1
Metal bindingi382Zinc 1; via carbonyl oxygenCombined sources1
Metal bindingi382Zinc 8Combined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processAntibiotic resistanceUniRule annotation
LigandMetal-bindingCombined sources, ZincCombined sources

Protein family/group databases

MEROPSiS12.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamaseUniRule annotation (EC:3.5.2.6UniRule annotation)
Gene namesi
Name:fox-4Imported
Encoded oniPlasmid pGC-2Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500432872524 – 382Beta-lactamaseSequence analysisAdd BLAST359

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CGSX-ray1.63A24-382[»]
5CGWX-ray1.40A24-382[»]
5CGXX-ray1.21A24-382[»]
5CHJX-ray1.36A/B24-382[»]
5CHMX-ray1.90A24-382[»]
5CHUX-ray1.10A/B24-382[»]
ProteinModelPortaliQ9L387.
SMRiQ9L387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 379Beta-lactamaseInterPro annotationAdd BLAST347

Sequence similaritiesi

Belongs to the class-C beta-lactamase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

KOiK19101.

Family and domain databases

InterProiView protein in InterPro
IPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR001586. Beta-lactam_class-C_AS.
PfamiView protein in Pfam
PF00144. Beta-lactamase. 1 hit.
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiView protein in PROSITE
PS00336. BETA_LACTAMASE_C. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9L387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQRRALALL MLGSLLLAPC TYASGEAPLT ATVDGIIQPM LKAYRIPGMA
60 70 80 90 100
VAVLKDGKAH YFNYGVANRE SGQRVSEQTL FEIGSVSKTL TATLGAYAAV
110 120 130 140 150
KGGFELDDKV SQHAPWLKGS AFDGVTMAEL ATYSAGGLPL QFPDEVDSND
160 170 180 190 200
KMQTYYRSWS PVYPAGTHRQ YSNPSIGLFG HLAANSLGQP FEQLMSQTLL
210 220 230 240 250
PKLGLHHTYI QVPESAMANY AYGYSKEDKP IRATPGVLAA EAYGIKTGSA
260 270 280 290 300
DLLKFVEANM GYQGDAALKS AIALTHTGFH SVGEMTQGLG WESYDYPVTE
310 320 330 340 350
QVLLAGNSPA VSFQANPVTR FAVPKAMGEQ RLYNKTGSTG GFGAYVAFVP
360 370 380
ARGIAIVMLA NRNYPIEARV KAAHAILSQL AE
Length:382
Mass (Da):40,961
Last modified:October 1, 2000 - v1
Checksum:i9476CE4C4A347A37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277535 Genomic DNA. Translation: CAB89086.1.
RefSeqiWP_032489727.1. NG_049104.1.

Genome annotation databases

KEGGiag:CAB89086.

Similar proteinsi

Entry informationi

Entry nameiQ9L387_ECOLX
AccessioniPrimary (citable) accession number: Q9L387
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, PlasmidImported