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Q9L289

- RUVC_STRCO

UniProt

Q9L289 - RUVC_STRCO

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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).

Cofactori

Binds 1 magnesium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi7 – 71MagnesiumBy similarity
Metal bindingi68 – 681MagnesiumBy similarity
Metal bindingi141 – 1411MagnesiumBy similarity
Metal bindingi144 – 1441MagnesiumBy similarity

GO - Molecular functioni

  1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvC (EC:3.1.22.4)
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene namesi
Name:ruvC
Ordered Locus Names:SCO1520
ORF Names:SCL2.10c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Crossover junction endodeoxyribonuclease RuvCPRO_0000183135Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO1520.

Structurei

3D structure databases

ProteinModelPortaliQ9L289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.Curated

Phylogenomic databases

eggNOGiCOG0817.
HOGENOMiHOG000012182.
InParanoidiQ9L289.
KOiK01159.
OMAiRQVQEMV.
OrthoDBiEOG6RG044.
PhylomeDBiQ9L289.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00034. RuvC.
InterProiIPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamiPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSiPR00696. RSOLVASERUVC.
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00228. ruvC. 1 hit.
PROSITEiPS01321. RUVC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9L289-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVLGVDPGL TRRGIGVVEG VAGRPLTMIG VGVVRTPADA DLGHRLVAVE
60 70 80 90 100
QGIEQWLDEH RPEFVAVERV FSQHNVRTVM GTAQASAVAI LCASRRGIPV
110 120 130 140 150
ALHTPSEVKA AVTGSGRADK AQVGAMVTRL LRLAAPPKPA DAADALALAI
160 170 180
CHIWRAPAQN RLQQAVALHT AQGPRRPHKL HPSKGRPA
Length:188
Mass (Da):19,890
Last modified:October 1, 2000 - v1
Checksum:iB19A98CF96A64B9B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939109 Genomic DNA. Translation: CAB70922.1.
RefSeqiNP_625799.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB70922; CAB70922; CAB70922.
GeneIDi1096946.
KEGGisco:SCO1520.
PATRICi23732616. VBIStrCoe124346_1529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939109 Genomic DNA. Translation: CAB70922.1 .
RefSeqi NP_625799.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9L289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO1520.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB70922 ; CAB70922 ; CAB70922 .
GeneIDi 1096946.
KEGGi sco:SCO1520.
PATRICi 23732616. VBIStrCoe124346_1529.

Phylogenomic databases

eggNOGi COG0817.
HOGENOMi HOG000012182.
InParanoidi Q9L289.
KOi K01159.
OMAi RQVQEMV.
OrthoDBi EOG6RG044.
PhylomeDBi Q9L289.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00034. RuvC.
InterProi IPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view ]
Pfami PF02075. RuvC. 1 hit.
[Graphical view ]
PRINTSi PR00696. RSOLVASERUVC.
SUPFAMi SSF53098. SSF53098. 1 hit.
TIGRFAMsi TIGR00228. ruvC. 1 hit.
PROSITEi PS01321. RUVC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiRUVC_STRCO
AccessioniPrimary (citable) accession number: Q9L289
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3