Q9L213 (AROA1_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase 1
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase 1
Short name=EPSP synthase 1
Short name=EPSPS 1

Gene names

Name:	aroA1
Ordered Locus Names:	SCO6819
ORF Names:	SC1A2.28c

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 440	440	3-phosphoshikimate 1-carboxyvinyltransferase 1 HAMAP MF_00210		PRO_0000088301

Sequences

	Sequence		Length	Mass (Da)
	Q9L213 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 77B720F81398EB0D	FASTA	440	46,530
	10 20 30 40 50 60 MSATPDPRLK AETLTIRTLT GFDETVRVLG SKSYTNRYLA IASLSGQETV IDNALLSDDT 70 80 90 100 110 120 VYFSRAIETF GHVTCDIDHA TARIRVTPTG RPMRAPSEDI FVGGAGTPLR FLISMAGHAD 130 140 150 160 170 180 GTTIITGNAR MQERPMGDLL KALPALGVDA TAVRGNGSPP VRVVGGSFKG GATSISGAVS 190 200 210 220 230 240 SQFTSSLIIN ALRAQTDTEI TISDDLVSKP YVEMTLAGLA EMGVSVDRDG YRRFTVPSGQ 250 260 270 280 290 300 QARGGQVTVE PDASGMSYFL AAAAILQSRV VIPGIGAGSH QGDVHLVQAL ERMGCRTEVG 310 320 330 340 350 360 DDSITVTGGP LRGIDIDMEA MPDVVPSLAI VAAYAEGTTR ITNIASLRVK ECDRIAAVTT 370 380 390 400 410 420 ELRKMGIDVE EHSDAMYITG GTPHGAVIDT YDDHRIAMTF AIGGLRTEGV VIKDPGCVAK 430 440 SFPAFWQTLD TLHPDLESTK

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939129 Genomic DNA. Translation: CAB71266.1.
RefSeq	NP_630891.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9L213.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1102258.
GenomeReviews	Gene locus SCO6819 in contig AL645882_GR.
KEGG	sco:SCO6819.
NMPDR	fig|100226.1.peg.6756.
PATRIC	23743567. VBIStrCoe124346_6928.
Phylogenomic databases
HOGENOM	HBG646626.
OMA	GADIEWG.
PhylomeDB	Q9L213.
ProtClustDB	PRK02427.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. False negative. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA1_STRCO

Accession

Primary (citable) accession number: Q9L213

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2003
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program