Reviewed,
UniProtKB/Swiss-Prot Q9L1L8 (K6PF2_STRCO)
Last modified
February 9, 2010.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: 6-phosphofructokinase 2 EC=2.7.1.11 Alternative name(s): Phosphofructokinase 2 Phosphohexokinase 2 | ||||||||
| Gene names |
| ||||||||
| Organism | Streptomyces coelicolor [Complete proteome] [HAMAP] | ||||||||
| Taxonomic identifier | 1902 [NCBI] | ||||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces |
Protein attributes
| Sequence length | 341 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. HAMAP MF_00339 |
| Pathway | Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. HAMAP MF_00339 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00339. |
| Sequence similarities | Belongs to the phosphofructokinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glycolysis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Allosteric enzyme Complete proteome |
| Gene Ontology (GO) | |
| Biological process | fructose 6-phosphate metabolic process Inferred from electronic annotation. Source: InterPro glycolysisInferred from electronic annotation. Source: HAMAP |
| Cellular component | 6-phosphofructokinase complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | 6-phosphofructokinase activity Inferred from electronic annotation. Source: HAMAP ATP bindingInferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 341 | 341 | 6-phosphofructokinase 2 HAMAP MF_00339 | PRO_0000111987 | |||||
Regions | |||||||||
| Nucleotide binding | 20 – 24 | 5 | ATP By similarity | ||||||
| Nucleotide binding | 154 – 158 | 5 | ATP By similarity | ||||||
| Nucleotide binding | 171 – 187 | 17 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 127 | 1 | Proton acceptor By similarity | ||||||
| Metal binding | 185 | 1 | Magnesium; via carbonyl oxygen By similarity | ||||||
| Binding site | 162 | 1 | Substrate By similarity | ||||||
| Binding site | 272 | 1 | Substrate By similarity | ||||||
| Binding site | 275 | 1 | Substrate By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. Hopwood D.A.Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL939123 Genomic DNA. Translation: CAB72402.1. |
| RefSeq | NP_629564.1. |
3D structure databases | |
| SMR | Q9L1L8. Positions 2-339. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1100866. |
| KEGG | sco:SCO5426. |
| NMPDR | fig|100226.1.peg.5378. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG405044. |
| OMA | ASSHKRV. |
Enzyme and pathway databases | |
| BioCyc | SCOE100226:SCO5426-MONOMER. |
| BRENDA | 2.7.1.11. 1084. |
Family and domain databases | |
| HAMAP | MF_00339. Phosphofructokinase. [Tree] |
| InterPro | IPR012003. ATP_PFK_prok. IPR012829. PFK. IPR000023. Phosphofructokinase. IPR015912. Phosphofructokinase_CS. [Graphical view] |
| Pfam | PF00365. PFK. 1 hit. [Graphical view] |
| PIRSF | PIRSF000532. ATP_PFK_prok. 1 hit. |
| PRINTS | PR00476. PHFRCTKINASE. |
| TIGRFAMs | TIGR02483. PFK_mixed. 1 hit. |
| PROSITE | PS00433. PHOSPHOFRUCTOKINASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | K6PF2_STRCO | ||||||||
| Accession | Primary (citable) accession number: Q9L1L8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


