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Protein

Chorismate dehydratase

Gene

mqnA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).UniRule annotation

Catalytic activityi

Chorismate = 3-((1-carboxyvinyl)oxy)benzoate + H2O.UniRule annotation

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotation1 Publication
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Menaquinone biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14866.
BRENDAi4.2.1.151. 5998.
UniPathwayiUPA00079.

Names & Taxonomyi

Protein namesi
Recommended name:
Chorismate dehydrataseUniRule annotation (EC:4.2.1.151UniRule annotation)
Alternative name(s):
Menaquinone biosynthetic enzyme MqnAUniRule annotation
Gene namesi
Name:mqnAUniRule annotation
Ordered Locus Names:SCO4506
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Pathology & Biotechi

Disruption phenotypei

Cells lacking this gene require menaquinone-4 (MK 4) for their growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Chorismate dehydratasePRO_0000425124Add
BLAST

Proteomic databases

PRIDEiQ9L0T8.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4506.

Structurei

Secondary structure

1
282
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 135Combined sources
Helixi16 – 183Combined sources
Helixi19 – 279Combined sources
Helixi30 – 334Combined sources
Beta strandi35 – 395Combined sources
Helixi41 – 499Combined sources
Beta strandi54 – 596Combined sources
Helixi60 – 656Combined sources
Helixi66 – 694Combined sources
Beta strandi70 – 8213Combined sources
Beta strandi85 – 939Combined sources
Beta strandi99 – 1068Combined sources
Helixi111 – 12212Combined sources
Beta strandi129 – 1335Combined sources
Beta strandi148 – 1503Combined sources
Helixi151 – 1599Combined sources
Helixi161 – 1644Combined sources
Beta strandi168 – 1714Combined sources
Helixi172 – 1809Combined sources
Beta strandi184 – 1929Combined sources
Helixi193 – 1986Combined sources
Helixi200 – 21920Combined sources
Helixi221 – 2299Combined sources
Beta strandi232 – 2343Combined sources
Helixi236 – 24510Combined sources
Helixi252 – 26514Combined sources
Turni267 – 2704Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NXOX-ray2.04A/B/C/D2-282[»]
ProteinModelPortaliQ9L0T8.
SMRiQ9L0T8. Positions 6-282.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9L0T8.

Family & Domainsi

Sequence similaritiesi

Belongs to the MqnA/MqnD family. MqnA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EV6. Bacteria.
COG1427. LUCA.
HOGENOMiHOG000016345.
InParanoidiQ9L0T8.
KOiK11782.
OMAiWGLARTG.
OrthoDBiEOG6JX7GK.
PhylomeDBiQ9L0T8.

Family and domain databases

HAMAPiMF_00995. MqnA.
InterProiIPR003773. Menaquinone_biosynth.
IPR030868. MqnA.
[Graphical view]
PfamiPF02621. VitK2_biosynth. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9L0T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNSRTRPRV GHIQFLNCLP LYWGLARTGT LLDFELTKDT PEKLSEQLVR
60 70 80 90 100
GDLDIGPVTL VEFLKNADDL VAFPDIAVGC DGPVMSCVIV SQVPLDRLDG
110 120 130 140 150
ARVALGSTSR TSVRLAQLLL SERFGVQPDY YTCPPDLSLM MQEADAAVLI
160 170 180 190 200
GDAALRANMI DGPRYGLDVH DLGALWKEWT GLPFVFAVWA ARRDYAEREP
210 220 230 240 250
VITRKVHEAF LASRNLSLEE VEKVAEQAAR WEAFDEDTLA KYFTTLDFRF
260 270 280
GAPQLEAVTE FARRVGPTTG FPADVKVELL KP
Length:282
Mass (Da):31,358
Last modified:October 1, 2000 - v1
Checksum:i687DB770ABC7BDB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB447888 Genomic DNA. Translation: BAG71674.1.
AL939120 Genomic DNA. Translation: CAB77297.1.
RefSeqiNP_628670.1. NC_003888.3.
WP_003974442.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB77297; CAB77297; CAB77297.
GeneIDi1099946.
KEGGisco:SCO4506.
PATRICi23738830. VBIStrCoe124346_4579.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB447888 Genomic DNA. Translation: BAG71674.1.
AL939120 Genomic DNA. Translation: CAB77297.1.
RefSeqiNP_628670.1. NC_003888.3.
WP_003974442.1. NC_003888.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NXOX-ray2.04A/B/C/D2-282[»]
ProteinModelPortaliQ9L0T8.
SMRiQ9L0T8. Positions 6-282.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO4506.

Proteomic databases

PRIDEiQ9L0T8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB77297; CAB77297; CAB77297.
GeneIDi1099946.
KEGGisco:SCO4506.
PATRICi23738830. VBIStrCoe124346_4579.

Phylogenomic databases

eggNOGiENOG4105EV6. Bacteria.
COG1427. LUCA.
HOGENOMiHOG000016345.
InParanoidiQ9L0T8.
KOiK11782.
OMAiWGLARTG.
OrthoDBiEOG6JX7GK.
PhylomeDBiQ9L0T8.

Enzyme and pathway databases

UniPathwayiUPA00079.
BioCyciMetaCyc:MONOMER-14866.
BRENDAi4.2.1.151. 5998.

Miscellaneous databases

EvolutionaryTraceiQ9L0T8.

Family and domain databases

HAMAPiMF_00995. MqnA.
InterProiIPR003773. Menaquinone_biosynth.
IPR030868. MqnA.
[Graphical view]
PfamiPF02621. VitK2_biosynth. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An alternative menaquinone biosynthetic pathway operating in microorganisms."
    Hiratsuka T., Furihata K., Ishikawa J., Yamashita H., Itoh N., Seto H., Dairi T.
    Science 321:1670-1673(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ROLE IN MENAQUINONE BIOSYNTHESIS, DISRUPTION PHENOTYPE, PATHWAY.
    Strain: ATCC BAA-471 / A3(2) / M145.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.
  3. "The crystal structure of a hypothetical protein SCO4506 (gene ID: Q9L0T8) from Streptomyces coelicolor to 2.04 Angstrom resolution."
    New York structural genomix research consortium (NYSGXRC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.04 ANGSTROMS).

Entry informationi

Entry nameiMQNA_STRCO
AccessioniPrimary (citable) accession number: Q9L0T8
Secondary accession number(s): B5MG03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: October 1, 2000
Last modified: November 11, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.