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Reviewed, UniProtKB/Swiss-Prot Q9L0Q6 (SYC1_STRCO)

Last modified November 3, 2009. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cysteinyl-tRNA synthetase 1
    EC=6.1.1.16
Alternative name(s):
    Cysteine--tRNA ligase 1
      Short name=CysRS 1
Gene names
Name: cysS1
Ordered Locus Names: SCO4235
ORF Names: SCD8A.08
OrganismStreptomyces coelicolor [Complete proteome] [HAMAP]
Taxonomic identifier1902 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

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Protein attributes

Sequence length613 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). HAMAP MF_00041

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm. HAMAP MF_00041

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

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Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   DomainRepeat
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcysteinyl-tRNA aminoacylation

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

cysteine-tRNA ligase activity

Inferred from electronic annotation. Source: HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 613613Cysteinyl-tRNA synthetase 1 HAMAP MF_00041
PRO_0000159490

Regions

Repeat36 – 49141 HAMAP MF_00041
Repeat50 – 63142 HAMAP MF_00041
Repeat64 – 77143 HAMAP MF_00041
Repeat78 – 91144 HAMAP MF_00041
Repeat92 – 105145 HAMAP MF_00041
Repeat106 – 119146 HAMAP MF_00041
Region36 – 119846 X 14 AA tandem repeats of P-[TA]-R-G-D-K-K-R-A-[RP]-R-[PL]-G-V HAMAP MF_00041
Region148 – 613466Cysteinyl-tRNA synthetase HAMAP MF_00041
Motif178 – 18811"HIGH" region HAMAP MF_00041
Motif411 – 4155"KMSKS" region HAMAP MF_00041

Sites

Metal binding1761Zinc By similarity
Metal binding3551Zinc By similarity
Metal binding3801Zinc By similarity
Metal binding3841Zinc By similarity
Binding site4141ATP By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9L0Q6-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 2224A3EA33AC6131

FASTA61367,539
        10         20         30         40         50         60 
MSAGAGTPRR PAVRGSAPHP ARGSAPGPRP MPTHHPTRGD KKRARRPGVP TRGDKKRAPR 

        70         80         90        100        110        120 
LGVPARGDKK RARRPGVPAR EDKKRAPRPG VPTRGDKKRA PRLGVPARGD KKRARRPGVP 

       130        140        150        160        170        180 
TRGGVARSGN DGPRVPLALL GAYYPGHVTI RLYDTSARQI RDFAPLTPGC VSIYLCGATV 

       190        200        210        220        230        240 
QAAPHIGHIR SGLNFDIMRR WFAYRGYDVT FVRNVTDIDD KIIRKAAEQN RPWWSIGYEN 

       250        260        270        280        290        300 
ERAFNDAYAA LGCLPPTYEP RATGHITEMV EMMRGLIERG HAYEADGNVY FDVRSLPGYL 

       310        320        330        340        350        360 
SLSNQDLDEL RQPSEDGETG KRDLRDFAMW KAAKPGEPSW ETPWGRGRPG WHLECSAMAH 

       370        380        390        400        410        420 
KYLGEEFDIH GGGIDLIFPH HENEIAQAKG FGDAFARYWV HNAWVTMSGE KMSKSLGNSV 

       430        440        450        460        470        480 
LVSEMVKKWP PVVLRYYLGT PHYRSTIEYS EESLREAESA YGRIEGFVQR VTELAGHAVE 

       490        500        510        520        530        540 
PAAEVPPAFA EAMDDDLGVP QALAIVHTTV RQGNSALAAD DKDAAVARLA EVRAMLGVLG 

       550        560        570        580        590        600 
LDPLDAQWAG AQAQGEDLRH VVDSLVRLVL DQREGARARK DWATADAIRD QLGQSGLVIE 

       610 
DSPQGPRWSL GSR

« Hide

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Cross-references

Sequence databases

AL939119 Genomic DNA. Translation: CAB77329.1.
RefSeqNP_628409.1.

3D structure databases

HSSPHSSP built from PDB template 1LI5 based on UniProtKB P21888.
ModBaseSearch...

Genome annotation databases

GeneID1099675.
GenomeReviewsGene locus SCO4235 in contig AL645882_GR.
KEGGsco:SCO4235.
NMPDRfig|100226.1.peg.4191.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9L0Q6.
OMAKKRARRP.

Enzyme and pathway databases

BioCycSCOE100226:SCO4235-MON.
BRENDA6.1.1.16. 1084.

Family and domain databases

HAMAPMF_00041. Divergent sequence.
[Tree]
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR015804. Cys-tRNA-synt_Ia_C.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR015803. Cys-tRNA-synt_Ia_N.
IPR002308. Cys-tRNA-synth_1a.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHERPTHR10890. Cys_tRNA-synt_1a. 1 hit.
PfamPF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSPR00983. TRNASYNTHCYS.
TIGRFAMsTIGR00435. cysS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. False negative.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameSYC1_STRCO
AccessionPrimary (citable) accession number: Q9L0Q6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 1, 2000
Last modified: November 3, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents