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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei192UniRule annotation1
Active sitei271Proton donorUniRule annotation1
Active sitei375UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenaseUniRule annotation
Gene namesi
Name:murBUniRule annotation
Ordered Locus Names:SCO4643
ORF Names:SCD82.14
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001792681 – 383UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST383

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4643.

Structurei

3D structure databases

ProteinModelPortaliQ9L0L7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 215FAD-binding PCMH-typeUniRule annotationAdd BLAST167

Sequence similaritiesi

Belongs to the MurB family.UniRule annotation
Contains 1 FAD-binding PCMH-type domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R4N. Bacteria.
COG0812. LUCA.
HOGENOMiHOG000284356.
InParanoidiQ9L0L7.
KOiK00075.
OMAiMQNIGAY.
OrthoDBiPOG091H02K7.
PhylomeDBiQ9L0L7.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 2 hits.
3.90.78.10. 1 hit.
HAMAPiMF_00037. MurB. 1 hit.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR21071. PTHR21071. 1 hit.
PfamiPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsiTIGR00179. murB. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9L0L7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTRRDVPAD RSGRSRVSRH PGLSVPSRTL EPVQELHDAP LAPLTTFRLG
60 70 80 90 100
GPATRLLTAT TDAEVIAAVR EADDTGTPLL LIGGGSNLVI GDKGFDGTAL
110 120 130 140 150
HIATRGFRLD GTTLELAAGE IWTDAVARTV EAGLAGVECL AGIPGSAGAT
160 170 180 190 200
PIQNVGAYGQ EVSATITEVT AYDRRSGETV ALSNADCAFS YRHSRFKAEP
210 220 230 240 250
ERYVVLRVRF ELENADGLSA PLRYAETARA LGVEAGDRVP LTAARETVLR
260 270 280 290 300
LRAGKGMVLD PEDHDTWSAG SFFTNPILTD EEFAAFRSRV AGRLGAAVEP
310 320 330 340 350
PAFPAGEGRV KTSAAWLIDK AGFTKGYGTG PARISTKHTL ALTNRGEATT
360 370 380
EDLLALAREV VAGVHEAFGV TLVNEPVTVG VAL
Length:383
Mass (Da):40,364
Last modified:October 1, 2000 - v1
Checksum:i51BA5E7DB3B19466
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939120 Genomic DNA. Translation: CAB77417.1.
RefSeqiNP_628804.1. NC_003888.3.
WP_011029789.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB77417; CAB77417; CAB77417.
GeneIDi1100084.
KEGGisco:SCO4643.
PATRICi23739106. VBIStrCoe124346_4714.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939120 Genomic DNA. Translation: CAB77417.1.
RefSeqiNP_628804.1. NC_003888.3.
WP_011029789.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9L0L7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO4643.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB77417; CAB77417; CAB77417.
GeneIDi1100084.
KEGGisco:SCO4643.
PATRICi23739106. VBIStrCoe124346_4714.

Phylogenomic databases

eggNOGiENOG4107R4N. Bacteria.
COG0812. LUCA.
HOGENOMiHOG000284356.
InParanoidiQ9L0L7.
KOiK00075.
OMAiMQNIGAY.
OrthoDBiPOG091H02K7.
PhylomeDBiQ9L0L7.

Enzyme and pathway databases

UniPathwayiUPA00219.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 2 hits.
3.90.78.10. 1 hit.
HAMAPiMF_00037. MurB. 1 hit.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR21071. PTHR21071. 1 hit.
PfamiPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsiTIGR00179. murB. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMURB_STRCO
AccessioniPrimary (citable) accession number: Q9L0L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.