Q9L0L6 (ADDL2_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative adenosine/adenine deaminase 2
EC=3.5.4.-

Alternative name(s):
Adenosine aminohydrolase 2

Gene names

Ordered Locus Names:	SCO4644
ORF Names:	SCD82.15c

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism By similarity.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adenine catabolic process Inferred from Biological aspect of Ancestor. Source: RefGenome hypoxanthine salvage Inferred from Biological aspect of Ancestor. Source: RefGenome purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular function	adenine deaminase activity Inferred from Biological aspect of Ancestor. Source: RefGenome metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Putative adenosine/adenine deaminase 2		PRO_0000194390
Sites
	Active site	207	1	Proton donor By similarity
	Metal binding	16	1	Zinc; catalytic By similarity
	Metal binding	18	1	Zinc; catalytic By similarity
	Metal binding	204	1	Zinc; catalytic By similarity
	Metal binding	285	1	Zinc; catalytic By similarity
	Binding site	18	1	Substrate By similarity
	Binding site	286	1	Substrate By similarity
	Site	228	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9L0L6 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 01C062B045E6A637	FASTA	343	37,673
	10 20 30 40 50 60 MERVRDVSEL PKAHLHLHFT GSMRPTTLLE LADKHGVRLP ETLTEALGRG ESPKLRATDE 70 80 90 100 110 120 RGWFRFQRLY DAARSCLQTP EDIQRLVREA AEEDLRDGSG WLEIQVDPTS YAPRLGGLIP 130 140 150 160 170 180 ALEIILDAVE TTVRDTGIGM RVLVAANRMK HPLDARTLAR LAVRYAERGV VGFGLSNDER 190 200 210 220 230 240 RGMARDFDRA FAIARDGGLL SAPHGGELTG PASVRDCLDD LEADRIGHGV RAAEDPRLLK 250 260 270 280 290 300 RLADRQVTCE VCPASNVALG VYEKPEDVPL RRLFEAGVPM ALGADDPLLF GSRLAAQYEI 310 320 330 340 AREHHGFTDA ELAELARQSV RGSAAPEEVK GKLLAGVDDW LVA

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939120 Genomic DNA. Translation: CAB77418.1.
RefSeq	NP_628805.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9L0L6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1100085.
GenomeReviews	Gene locus SCO4644 in contig AL645882_GR.
KEGG	sco:SCO4644.
NMPDR	fig|100226.1.peg.4599.
PATRIC	23739108. VBIStrCoe124346_4715.
Phylogenomic databases
HOGENOM	HBG630382.
OMA	WFRFQRL.
PhylomeDB	Q9L0L6.
ProtClustDB	PRK09358.
Family and domain databases
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADDL2_STRCO

Accession

Primary (citable) accession number: Q9L0L6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program