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Protein

GMP synthase [glutamine-hydrolyzing]

Gene

guaA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of GMP from XMP.By similarity

Catalytic activityi

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.

Pathwayi: GMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GMP from XMP (L-Gln route).
Proteins known to be involved in this subpathway in this organism are:
  1. GMP synthase [glutamine-hydrolyzing] (guaA)
This subpathway is part of the pathway GMP biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GMP from XMP (L-Gln route), the pathway GMP biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei90 – 901NucleophileBy similarity
Active sitei178 – 1781By similarity
Active sitei180 – 1801By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi232 – 2387ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00189; UER00296.

Protein family/group databases

MEROPSiC26.A07.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP synthase [glutamine-hydrolyzing] (EC:6.3.5.2)
Alternative name(s):
GMP synthetase
Glutamine amidotransferase
Gene namesi
Name:guaA
Ordered Locus Names:SCO4785
ORF Names:SCD63.17
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526GMP synthase [glutamine-hydrolyzing]PRO_0000140186Add
BLAST

Proteomic databases

PRIDEiQ9L0H2.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi100226.SCO4785.

Structurei

3D structure databases

ProteinModelPortaliQ9L0H2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 204192Glutamine amidotransferase type-1Add
BLAST
Domaini205 – 400196GMPS ATP-PPaseAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiENOG4105CM0. Bacteria.
COG0518. LUCA.
COG0519. LUCA.
HOGENOMiHOG000223964.
InParanoidiQ9L0H2.
KOiK01951.
OMAiMILVLDF.
OrthoDBiPOG091H00MK.
PhylomeDBiQ9L0H2.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_00344. GMP_synthase. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9L0H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSATPAAAA PDTVLVVDFG AQYAQLIARR VREARVYSEI VPSSMPVEEI
60 70 80 90 100
LAKNPAAIIL SGGPSSVYEA GAPTLDRSLF EAGVPVFGMC YGFQLMAQTL
110 120 130 140 150
GGTVDNSGAR EYGRTELAVS KPSSTLFEGT PAEQSVWMSH GDACSAAPEG
160 170 180 190 200
FTVTGSTDVV PVAAFENDEK KLYGVQYHPE VMHSTHGQQV LEHFLYRGAG
210 220 230 240 250
LSPDWTTGNV IEEQVAAIRA QVGDRRAICG LSGGVDSAVA AALVQKAIGS
260 270 280 290 300
QLTCVYVDHG LMRKGETEQV EKDFVAATGV QLKVVDASER FLGALAGVSD
310 320 330 340 350
PEQKRKIIGR EFIRVFEQAQ LEIMREDGPE VAFLVQGTLY PDVVESGGGT
360 370 380 390 400
GTANIKSHHN VGGLPDDIEF ELVEPLRQLF KDEVRMVGQE LGLPDEIVQR
410 420 430 440 450
QPFPGPGLGI RIVGEVTKER LDLLREADAI AREELTAAGL DRDIWQCPVV
460 470 480 490 500
LLADVRSVGV QGDGRTYGHP IVLRPVSSED AMTADWSRLP YEVLSKISTR
510 520
ITNEVTDVNR VVLDVTSKPP GTIEWE
Length:526
Mass (Da):56,613
Last modified:October 1, 2000 - v1
Checksum:i43ACC404EE19EEA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939121 Genomic DNA. Translation: CAB82024.1.
RefSeqiNP_628943.1. NC_003888.3.
WP_003974187.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB82024; CAB82024; CAB82024.
GeneIDi1100226.
KEGGisco:SCO4785.
PATRICi23739398. VBIStrCoe124346_4859.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939121 Genomic DNA. Translation: CAB82024.1.
RefSeqiNP_628943.1. NC_003888.3.
WP_003974187.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9L0H2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO4785.

Protein family/group databases

MEROPSiC26.A07.

Proteomic databases

PRIDEiQ9L0H2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB82024; CAB82024; CAB82024.
GeneIDi1100226.
KEGGisco:SCO4785.
PATRICi23739398. VBIStrCoe124346_4859.

Phylogenomic databases

eggNOGiENOG4105CM0. Bacteria.
COG0518. LUCA.
COG0519. LUCA.
HOGENOMiHOG000223964.
InParanoidiQ9L0H2.
KOiK01951.
OMAiMILVLDF.
OrthoDBiPOG091H00MK.
PhylomeDBiQ9L0H2.

Enzyme and pathway databases

UniPathwayiUPA00189; UER00296.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_00344. GMP_synthase. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUAA_STRCO
AccessioniPrimary (citable) accession number: Q9L0H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.