Q9L0B8 (XYLA_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xylose isomerase
EC=5.3.1.5

Gene names

Name:	xylA
Ordered Locus Names:	SCO1169
ORF Names:	2SCG11.03c

Organism

Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]

Taxonomic identifier

100226 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces › Streptomyces coelicolor

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP-Rule MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	D-xylose metabolic process Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP xylose isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Xylose isomerase HAMAP-Rule MF_00455		PRO_0000195798
Sites
	Active site	54	1	By similarity
	Active site	57	1	By similarity
	Metal binding	181	1	Magnesium 1 By similarity
	Metal binding	217	1	Magnesium 1 By similarity
	Metal binding	217	1	Magnesium 2 By similarity
	Metal binding	220	1	Magnesium 2 By similarity
	Metal binding	245	1	Magnesium 1 By similarity
	Metal binding	255	1	Magnesium 2 By similarity
	Metal binding	257	1	Magnesium 2 By similarity
	Metal binding	287	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9L0B8 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 1880BC380D957681	FASTA	387	42,918
	10 20 30 40 50 60 MNYQPTPEDR FTFGLWTVGW QGRDPFGDAT RQALDPAESV RRLSELGAYG VTFHDDDLIP 70 80 90 100 110 120 FGSSDTERES HIKRFRQALD ATGMKVPMAT TNLFTHPVFK DGAFTANDRD VRRYALRKTI 130 140 150 160 170 180 RNIDLAVELG ASVYVAWGGR EGAESGAAKD VRDALDRMKE AFDLLGEYVT EQGYDLKFAI 190 200 210 220 230 240 EPKPNEPRGD ILLPTVGHAL AFIERLERPE LYGVNPEVGH EQMAGLNFPH GIAQALWAGK 250 260 270 280 290 300 LFHIDLNGQS GIKYDQDLRF GAGDLRAAFW LVDLLERAGY AGPRHFDFKP PRTEDFDGVW 310 320 330 340 350 360 ASAAGCMRNY LILKDRAAAF RADPQVQEAL AAARLDELAR PTAEDGLAAL LADRSAYDTF 370 380 DVDAAAARGM AFEHLDQLAM DHLLGAR

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939108 Genomic DNA. Translation: CAB82827.1.
RefSeq	NP_625460.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9L0B8.
SMR	Q9L0B8. Positions 1-387.
ModBase	Search...
Protein-protein interaction databases
STRING	100226.SCO1169.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB82827; CAB82827; CAB82827.
GeneID	1096592.
KEGG	sco:SCO1169.
PATRIC	23731888. VBIStrCoe124346_1167.
Phylogenomic databases
eggNOG	COG2115.
HOGENOM	HOG000022596.
KO	K01805.
OMA	DLVFGHG.
ProtClustDB	PRK12677.
Family and domain databases
Gene3D	3.20.20.150. 1 hit.
HAMAP	MF_00455. Xylose_isom_A.
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR013453. XylA_actinobac. IPR001998. Xylose_isomerase. [Graphical view]
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR02631. xylA_Arthro. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA_STRCO

Accession

Primary (citable) accession number: Q9L0B8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program