ID   Q9L096_STRCO            Unreviewed;      1349 AA.
AC   Q9L096;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   27-MAR-2024, entry version 130.
DE   SubName: Full=Serine/threonine protein kinase (Regulator) {ECO:0000313|EMBL:CAB86115.1};
GN   OrderedLocusNames=SCO2450 {ECO:0000313|EMBL:CAB86115.1};
GN   ORFNames=SCC24.21 {ECO:0000313|EMBL:CAB86115.1};
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226 {ECO:0000313|EMBL:CAB86115.1, ECO:0000313|Proteomes:UP000001973};
RN   [1] {ECO:0000313|EMBL:CAB86115.1, ECO:0000313|Proteomes:UP000001973}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145
RC   {ECO:0000313|Proteomes:UP000001973};
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA   Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
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DR   EMBL; AL939112; CAB86115.1; -; Genomic_DNA.
DR   RefSeq; NP_626693.1; NC_003888.3.
DR   RefSeq; WP_011028360.1; NZ_VNID01000001.1.
DR   STRING; 100226.gene:17760049; -.
DR   PaxDb; 100226-SCO2450; -.
DR   PATRIC; fig|100226.15.peg.2492; -.
DR   eggNOG; COG0515; Bacteria.
DR   eggNOG; COG1262; Bacteria.
DR   eggNOG; COG3629; Bacteria.
DR   HOGENOM; CLU_005743_0_0_11; -.
DR   InParanoid; Q9L096; -.
DR   OrthoDB; 4495511at2; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR005158; BTAD.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR047738; SAV_2336-like_N.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   NCBIfam; NF041121; SAV_2336_NTERM; 1.
DR   PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR   PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR   Pfam; PF03704; BTAD; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM01043; BTAD; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Kinase {ECO:0000313|EMBL:CAB86115.1};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00022707};
KW   Myristate {ECO:0000256|ARBA:ARBA00022707};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:CAB86115.1};
KW   Transferase {ECO:0000313|EMBL:CAB86115.1};
KW   Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT   DOMAIN          588..981
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          39..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          530..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1059..1109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1140..1172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..69
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..111
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1148..1169
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1349 AA;  145672 MW;  F0902A235D694B38 CRC64;
     MPTDRPGTPD PPPLPLLADL LGRAATGARP TPLELAELLW LAGHMEPPEQ DPPDGPASGT
     RPAEPPPAPE GTREQGQEGD GQRERDRKPE RDRHGDRERD RDGDRDRGPG RGPWGDGPGR
     PSTRSEAPRT PLRLPSPAPA PGTSAAQPHS ALLAPAPPML RHTLALQRAL RPLKRRADAP
     VGHEVDEAAT ADRIARLGAG PEWWLPVLRP VRERWLRLHL VHDAGPTMPV WRPLVRELQA
     ALAQSGVFRT VTLHRADPDG TVRGDGAQIP ADGRTVMLLI SDCMGPQWRA GPDGVRWFAT
     LRRWARRAPL AVLQPLPEQL WRDTALPPVP GRLSAPHRAA PSASLAFTPY DTAAPRAPEG
     TVHVPVLEPG PEWLANWAAL VASPGGTPYP GAAAALHRPL PADADDRTDV ARLSPEELVL
     RFRASASPQA YRLAGHLALG RPDLPVMRLV QAAVEPDPRP QHLAEVILGG LLTTVAGPPG
     SYAFRPGVRE LLLRGLPRTA RNRTHDLLLR TGGLIDDRAG RSPGEFRALI PSRKGTERAG
     PSESFATISE ESVRQLTVRE RPSAPSPFPP GLGARYRPTR RLTPSGRIWL AEDTGPDRTA
     PDRTPADRTA AHPVPTNRTV AIRLHDPATG PAARQTFLRN ARRLTRLSHP NLVTVLDAGI
     EGDVPYVVME HLDGIALGAL TRSGDGRLPV PLTVSVGAQL ARALTALHRA GLAHGGLEAS
     RVVLLPDGTV RLSLFEPALA LGPGARSADL RALCEVLLRL TSGTSRPAVP VDSRRLHRLP
     TALRIHYAHA FDQLLSPSPA AQARGLDLLG DPALLARAGE AYAPRRYRAL GPLRVGLPDG
     PADLPRDVRA LLAMLLLKHG RTVTHEELRW GLWDPGNEPR NPRSETTRLA KRLAEILGPG
     VLATAAHGYA LHTSADELDL VRCDELVRRA DAARLEGALA EAHDLVSGAL SLWGDAEPLA
     GVPGPAARTA RTRLLRLRLA LHTKRAELDL VLGEYDRAAA ELSGLLRAHP HREDFRRLCL
     IALRRQGRVE EALEVYEEYE LSGGRSPALT ALGRELREEY AEPVDDAPPW TEYEQRPVEP
     GAPESTVSAP DELPEGPFPT EDGLWTPLLD DDAEHDTAQA RAEADEREER AESRAALREA
     MRAEGLEPEP ELDEDPGPEE EEEPDEPPWI DFDTGFRACA RYTLADGPVD RDARAALHGL
     VTELLADSGA DAAAYELVDE PGGPLVLLAP RAEAAPLLRA TVEGLPGRLA RLAGLRLRIE
     FWQVEFGLDG NGEQSLGRAD ADAVGAVLDA SAAQAVVVLS DSLYYDEVRE EGQYGPAFPP
     DLFRPLADDT GWYHLVEGGG RPGPAADLR
//