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Protein
Submitted name:

Isocitrate dehydrogenase

Gene

SCO7000

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported
Gene namesi
Ordered Locus Names:SCO7000Imported
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)Imported
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO7000.

Structurei

3D structure databases

ProteinModelPortaliQ9KZF3.
SMRiQ9KZF3. Positions 4-738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000240860.
InParanoidiQ9KZF3.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.
PhylomeDBiQ9KZF3.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KZF3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDSTIIYTH TDEAPALATY SFLPVVRAYA SQAGVAVETR DISLAGRIIA
60 70 80 90 100
LFPEYLTEDQ RIPDALAELG ELAKTPAANI IKLPNISASI PQLKAAVAEL
110 120 130 140 150
QGQGYALPAY PDDPKTDEER DIRARYDKVK GSAVNPVLRE GNSDRRAPAS
160 170 180 190 200
VKNYAKTHPH RMGAWTGESK TNVATMGEND FRSTEKSAVI AEDGTLRIEL
210 220 230 240 250
VGDDGTTTVL RESVPVKKDE VVDASVLRVA ALREFLTAQV ARAKAEGILY
260 270 280 290 300
SVHLKATMMK VSDPIIFGHV VRAFFPKTFA QYGDVLAKAG LTPNDGLGGI
310 320 330 340 350
YKGLESLPEG AEIKASFDAE LAEGPELAMV DSDKGITNLH VPSDVIIDAS
360 370 380 390 400
MPAMIRTSGH MWGADGGEHD ALAVIPDSSY AGVYQAVIED CRANGAYDPS
410 420 430 440 450
TMGSVPNVGL MAQKAEEYGS HDKTFEIPTT GTVRLVDAAG NAVLEQTVSA
460 470 480 490 500
GDIFRACQTK DAPIRDWVKL AVTRARATGD PAVFWLDEGR AHDANLIAKV
510 520 530 540 550
KQYLSEHDTE GLDIRILDPV EATKLSVERI RRGENTISVT GNVLRDYLTD
560 570 580 590 600
LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKEDYLRWD
610 620 630 640 650
SLGEFFALVP SLEKYAEATG NGKAKVLADT LDRATATFLN EDKSPTRRVG
660 670 680 690 700
GIDNRGSHFY LSLYWAQELA KQTDDADLAK AFAPLAETLT ASEQKIVEEL
710 720 730
NAVQGKPAEI GGYYQPDPAK AAKIMRPSTT WNEALASLA
Length:739
Mass (Da):79,520
Last modified:October 1, 2000 - v1
Checksum:iFCDF3F1D006AFC2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939130 Genomic DNA. Translation: CAB88977.1.
RefSeqiNP_631065.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB88977; CAB88977; CAB88977.
GeneIDi1102438.
KEGGisco:SCO7000.
PATRICi23743919. VBIStrCoe124346_7102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939130 Genomic DNA. Translation: CAB88977.1.
RefSeqiNP_631065.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9KZF3.
SMRiQ9KZF3. Positions 4-738.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO7000.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB88977; CAB88977; CAB88977.
GeneIDi1102438.
KEGGisco:SCO7000.
PATRICi23743919. VBIStrCoe124346_7102.

Phylogenomic databases

HOGENOMiHOG000240860.
InParanoidiQ9KZF3.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.
PhylomeDBiQ9KZF3.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145Imported.

Entry informationi

Entry nameiQ9KZF3_STRCO
AccessioniPrimary (citable) accession number: Q9KZF3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.