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Q9KZF3

- Q9KZF3_STRCO

UniProt

Q9KZF3 - Q9KZF3_STRCO

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Protein
Submitted name:

Isocitrate dehydrogenase

Gene
SCO7000
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Unreviewed - Annotation score: 1 out of 5 - Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei145 – 1451Substrate By similarity
Sitei255 – 2551Critical for catalysis By similarityUniRule annotation
Metal bindingi348 – 3481Magnesium or manganese By similarityUniRule annotation
Sitei418 – 4181Critical for catalysis By similarityUniRule annotation
Binding sitei545 – 5451Substrate By similarityUniRule annotation
Metal bindingi546 – 5461Magnesium or manganese By similarityUniRule annotation
Metal bindingi550 – 5501Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported
Gene namesi
Ordered Locus Names:SCO7000Imported
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO7000.

Structurei

3D structure databases

ProteinModelPortaliQ9KZF3.
SMRiQ9KZF3. Positions 4-738.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 1398Substrate binding By similarity

Phylogenomic databases

HOGENOMiHOG000240860.
KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.
PhylomeDBiQ9KZF3.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KZF3-1 [UniParc]FASTAAdd to Basket

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MTDSTIIYTH TDEAPALATY SFLPVVRAYA SQAGVAVETR DISLAGRIIA    50
LFPEYLTEDQ RIPDALAELG ELAKTPAANI IKLPNISASI PQLKAAVAEL 100
QGQGYALPAY PDDPKTDEER DIRARYDKVK GSAVNPVLRE GNSDRRAPAS 150
VKNYAKTHPH RMGAWTGESK TNVATMGEND FRSTEKSAVI AEDGTLRIEL 200
VGDDGTTTVL RESVPVKKDE VVDASVLRVA ALREFLTAQV ARAKAEGILY 250
SVHLKATMMK VSDPIIFGHV VRAFFPKTFA QYGDVLAKAG LTPNDGLGGI 300
YKGLESLPEG AEIKASFDAE LAEGPELAMV DSDKGITNLH VPSDVIIDAS 350
MPAMIRTSGH MWGADGGEHD ALAVIPDSSY AGVYQAVIED CRANGAYDPS 400
TMGSVPNVGL MAQKAEEYGS HDKTFEIPTT GTVRLVDAAG NAVLEQTVSA 450
GDIFRACQTK DAPIRDWVKL AVTRARATGD PAVFWLDEGR AHDANLIAKV 500
KQYLSEHDTE GLDIRILDPV EATKLSVERI RRGENTISVT GNVLRDYLTD 550
LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKEDYLRWD 600
SLGEFFALVP SLEKYAEATG NGKAKVLADT LDRATATFLN EDKSPTRRVG 650
GIDNRGSHFY LSLYWAQELA KQTDDADLAK AFAPLAETLT ASEQKIVEEL 700
NAVQGKPAEI GGYYQPDPAK AAKIMRPSTT WNEALASLA 739
Length:739
Mass (Da):79,520
Last modified:October 1, 2000 - v1
Checksum:iFCDF3F1D006AFC2D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939130 Genomic DNA. Translation: CAB88977.1.
RefSeqiNP_631065.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB88977; CAB88977; CAB88977.
GeneIDi1102438.
KEGGisco:SCO7000.
PATRICi23743919. VBIStrCoe124346_7102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939130 Genomic DNA. Translation: CAB88977.1 .
RefSeqi NP_631065.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9KZF3.
SMRi Q9KZF3. Positions 4-738.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO7000.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB88977 ; CAB88977 ; CAB88977 .
GeneIDi 1102438.
KEGGi sco:SCO7000.
PATRICi 23743919. VBIStrCoe124346_7102.

Phylogenomic databases

HOGENOMi HOG000240860.
KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.
PhylomeDBi Q9KZF3.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiQ9KZF3_STRCO
AccessioniPrimary (citable) accession number: Q9KZF3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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