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Q9KZF3

- Q9KZF3_STRCO

UniProt

Q9KZF3 - Q9KZF3_STRCO

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Protein
Submitted name:

Isocitrate dehydrogenase

Gene

SCO7000

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei145 – 1451SubstrateUniRule annotation
Sitei255 – 2551Critical for catalysis
Metal bindingi348 – 3481Magnesium or manganeseUniRule annotation
Sitei418 – 4181Critical for catalysisUniRule annotation
Binding sitei545 – 5451SubstrateUniRule annotation
Metal bindingi546 – 5461Magnesium or manganeseUniRule annotation
Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenaseImported
Gene namesi
Ordered Locus Names:SCO7000Imported
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)Imported
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO7000.

Structurei

3D structure databases

ProteinModelPortaliQ9KZF3.
SMRiQ9KZF3. Positions 4-738.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 1398Substrate bindingUniRule annotation

Phylogenomic databases

HOGENOMiHOG000240860.
InParanoidiQ9KZF3.
KOiK00031.
OMAiEEQRIGD.
OrthoDBiEOG6DVJPP.
PhylomeDBiQ9KZF3.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KZF3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDSTIIYTH TDEAPALATY SFLPVVRAYA SQAGVAVETR DISLAGRIIA
60 70 80 90 100
LFPEYLTEDQ RIPDALAELG ELAKTPAANI IKLPNISASI PQLKAAVAEL
110 120 130 140 150
QGQGYALPAY PDDPKTDEER DIRARYDKVK GSAVNPVLRE GNSDRRAPAS
160 170 180 190 200
VKNYAKTHPH RMGAWTGESK TNVATMGEND FRSTEKSAVI AEDGTLRIEL
210 220 230 240 250
VGDDGTTTVL RESVPVKKDE VVDASVLRVA ALREFLTAQV ARAKAEGILY
260 270 280 290 300
SVHLKATMMK VSDPIIFGHV VRAFFPKTFA QYGDVLAKAG LTPNDGLGGI
310 320 330 340 350
YKGLESLPEG AEIKASFDAE LAEGPELAMV DSDKGITNLH VPSDVIIDAS
360 370 380 390 400
MPAMIRTSGH MWGADGGEHD ALAVIPDSSY AGVYQAVIED CRANGAYDPS
410 420 430 440 450
TMGSVPNVGL MAQKAEEYGS HDKTFEIPTT GTVRLVDAAG NAVLEQTVSA
460 470 480 490 500
GDIFRACQTK DAPIRDWVKL AVTRARATGD PAVFWLDEGR AHDANLIAKV
510 520 530 540 550
KQYLSEHDTE GLDIRILDPV EATKLSVERI RRGENTISVT GNVLRDYLTD
560 570 580 590 600
LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKEDYLRWD
610 620 630 640 650
SLGEFFALVP SLEKYAEATG NGKAKVLADT LDRATATFLN EDKSPTRRVG
660 670 680 690 700
GIDNRGSHFY LSLYWAQELA KQTDDADLAK AFAPLAETLT ASEQKIVEEL
710 720 730
NAVQGKPAEI GGYYQPDPAK AAKIMRPSTT WNEALASLA
Length:739
Mass (Da):79,520
Last modified:October 1, 2000 - v1
Checksum:iFCDF3F1D006AFC2D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939130 Genomic DNA. Translation: CAB88977.1.
RefSeqiNP_631065.1. NC_003888.3.
WP_011031369.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB88977; CAB88977; CAB88977.
GeneIDi1102438.
KEGGisco:SCO7000.
PATRICi23743919. VBIStrCoe124346_7102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939130 Genomic DNA. Translation: CAB88977.1 .
RefSeqi NP_631065.1. NC_003888.3.
WP_011031369.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9KZF3.
SMRi Q9KZF3. Positions 4-738.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO7000.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB88977 ; CAB88977 ; CAB88977 .
GeneIDi 1102438.
KEGGi sco:SCO7000.
PATRICi 23743919. VBIStrCoe124346_7102.

Phylogenomic databases

HOGENOMi HOG000240860.
InParanoidi Q9KZF3.
KOi K00031.
OMAi EEQRIGD.
OrthoDBi EOG6DVJPP.
PhylomeDBi Q9KZF3.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145Imported.

Entry informationi

Entry nameiQ9KZF3_STRCO
AccessioniPrimary (citable) accession number: Q9KZF3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3