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Q9KZF3

- Q9KZF3_STRCO

UniProt

Q9KZF3 - Q9KZF3_STRCO

Protein
Submitted name:

Isocitrate dehydrogenase

Gene

SCO7000

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei145 – 1451SubstrateUniRule annotation
    Sitei255 – 2551Critical for catalysis
    Metal bindingi348 – 3481Magnesium or manganeseUniRule annotation
    Sitei418 – 4181Critical for catalysisUniRule annotation
    Binding sitei545 – 5451SubstrateUniRule annotation
    Metal bindingi546 – 5461Magnesium or manganeseUniRule annotation
    Metal bindingi550 – 5501Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenaseImported
    Gene namesi
    Ordered Locus Names:SCO7000Imported
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)Imported
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO7000.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KZF3.
    SMRiQ9KZF3. Positions 4-738.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni132 – 1398Substrate bindingUniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000240860.
    KOiK00031.
    OMAiEEQRIGD.
    OrthoDBiEOG6DVJPP.
    PhylomeDBiQ9KZF3.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9KZF3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDSTIIYTH TDEAPALATY SFLPVVRAYA SQAGVAVETR DISLAGRIIA    50
    LFPEYLTEDQ RIPDALAELG ELAKTPAANI IKLPNISASI PQLKAAVAEL 100
    QGQGYALPAY PDDPKTDEER DIRARYDKVK GSAVNPVLRE GNSDRRAPAS 150
    VKNYAKTHPH RMGAWTGESK TNVATMGEND FRSTEKSAVI AEDGTLRIEL 200
    VGDDGTTTVL RESVPVKKDE VVDASVLRVA ALREFLTAQV ARAKAEGILY 250
    SVHLKATMMK VSDPIIFGHV VRAFFPKTFA QYGDVLAKAG LTPNDGLGGI 300
    YKGLESLPEG AEIKASFDAE LAEGPELAMV DSDKGITNLH VPSDVIIDAS 350
    MPAMIRTSGH MWGADGGEHD ALAVIPDSSY AGVYQAVIED CRANGAYDPS 400
    TMGSVPNVGL MAQKAEEYGS HDKTFEIPTT GTVRLVDAAG NAVLEQTVSA 450
    GDIFRACQTK DAPIRDWVKL AVTRARATGD PAVFWLDEGR AHDANLIAKV 500
    KQYLSEHDTE GLDIRILDPV EATKLSVERI RRGENTISVT GNVLRDYLTD 550
    LFPILELGTS AKMLSVVPLM AGGGLFETGA GGSAPKHVQQ LVKEDYLRWD 600
    SLGEFFALVP SLEKYAEATG NGKAKVLADT LDRATATFLN EDKSPTRRVG 650
    GIDNRGSHFY LSLYWAQELA KQTDDADLAK AFAPLAETLT ASEQKIVEEL 700
    NAVQGKPAEI GGYYQPDPAK AAKIMRPSTT WNEALASLA 739
    Length:739
    Mass (Da):79,520
    Last modified:October 1, 2000 - v1
    Checksum:iFCDF3F1D006AFC2D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939130 Genomic DNA. Translation: CAB88977.1.
    RefSeqiNP_631065.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB88977; CAB88977; CAB88977.
    GeneIDi1102438.
    KEGGisco:SCO7000.
    PATRICi23743919. VBIStrCoe124346_7102.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939130 Genomic DNA. Translation: CAB88977.1 .
    RefSeqi NP_631065.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9KZF3.
    SMRi Q9KZF3. Positions 4-738.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO7000.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB88977 ; CAB88977 ; CAB88977 .
    GeneIDi 1102438.
    KEGGi sco:SCO7000.
    PATRICi 23743919. VBIStrCoe124346_7102.

    Phylogenomic databases

    HOGENOMi HOG000240860.
    KOi K00031.
    OMAi EEQRIGD.
    OrthoDBi EOG6DVJPP.
    PhylomeDBi Q9KZF3.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145Imported.

    Entry informationi

    Entry nameiQ9KZF3_STRCO
    AccessioniPrimary (citable) accession number: Q9KZF3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3