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Q9KZA7

- SYW2_STRCO

UniProt

Q9KZA7 - SYW2_STRCO

Protein

Tryptophan--tRNA ligase 2

Gene

trpS2

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei204 – 2041ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligase 2UniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetase 2UniRule annotation
    Short name:
    TrpRS 2UniRule annotation
    Gene namesi
    Name:trpS2UniRule annotation
    Synonyms:trpS
    Ordered Locus Names:SCO4839
    ORF Names:SC5G8.07
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Tryptophan--tRNA ligase 2PRO_0000136688Add
    BLAST

    Proteomic databases

    PRIDEiQ9KZA7.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi100226.SCO4839.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KZA7.
    SMRiQ9KZA7. Positions 8-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi16 – 2510"HIGH" region
    Motifi201 – 2055"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000059940.
    KOiK01867.
    OMAiIDPKKHI.
    OrthoDBiEOG686NJQ.
    PhylomeDBiQ9KZA7.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_B. Trp_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KZA7-1 [UniParc]FASTAAdd to Basket

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    MSMANERPRV LSGIQPTSGS FHLGNYLGAV RQWVDMQDTH DAFYMVVDLH    50
    AITVPQDPKE LRENTRVAAA QLLAAGLDPD RCTLFVQSHV PEHAQLGWLM 100
    NCITGFGEAS RMTQFKDKSA KQGNDRTTVG LFTYPMLMVA DILLYQADQV 150
    PVGEDQRQHL ELTRDLADRF NQTYGDAFTV PTAYILKETA KIYDLQDPTA 200
    KMSKSAATPK GLINLLDEPK ATAKKVKSAV TDTDTVVRFD RETKPGVSNL 250
    LTIYSTLTGA EIAELERKYE GKGYGALKTD LADVVVEFVT PFRERTRQYL 300
    DDPETLDAIL AKGAEKARSV AAETLARAYD EVGFLPAKH 339
    Length:339
    Mass (Da):37,593
    Last modified:October 1, 2000 - v1
    Checksum:iC45FC36D081D0197
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939121 Genomic DNA. Translation: CAB89058.1.
    RefSeqiNP_628994.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB89058; CAB89058; CAB89058.
    GeneIDi1100280.
    KEGGisco:SCO4839.
    PATRICi23739510. VBIStrCoe124346_4915.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939121 Genomic DNA. Translation: CAB89058.1 .
    RefSeqi NP_628994.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9KZA7.
    SMRi Q9KZA7. Positions 8-335.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO4839.

    Proteomic databases

    PRIDEi Q9KZA7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB89058 ; CAB89058 ; CAB89058 .
    GeneIDi 1100280.
    KEGGi sco:SCO4839.
    PATRICi 23739510. VBIStrCoe124346_4915.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000059940.
    KOi K01867.
    OMAi IDPKKHI.
    OrthoDBi EOG686NJQ.
    PhylomeDBi Q9KZA7.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_B. Trp_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiSYW2_STRCO
    AccessioniPrimary (citable) accession number: Q9KZA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3