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Q9KZA7

- SYW2_STRCO

UniProt

Q9KZA7 - SYW2_STRCO

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Protein

Tryptophan--tRNA ligase 2

Gene

trpS2

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei204 – 2041ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase 2UniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetase 2UniRule annotation
Short name:
TrpRS 2UniRule annotation
Gene namesi
Name:trpS2UniRule annotation
Synonyms:trpS
Ordered Locus Names:SCO4839
ORF Names:SC5G8.07
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Tryptophan--tRNA ligase 2PRO_0000136688Add
BLAST

Proteomic databases

PRIDEiQ9KZA7.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO4839.

Structurei

3D structure databases

ProteinModelPortaliQ9KZA7.
SMRiQ9KZA7. Positions 8-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi16 – 2510"HIGH" region
Motifi201 – 2055"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000059940.
InParanoidiQ9KZA7.
KOiK01867.
OMAiIDPKKHI.
OrthoDBiEOG686NJQ.
PhylomeDBiQ9KZA7.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KZA7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSMANERPRV LSGIQPTSGS FHLGNYLGAV RQWVDMQDTH DAFYMVVDLH
60 70 80 90 100
AITVPQDPKE LRENTRVAAA QLLAAGLDPD RCTLFVQSHV PEHAQLGWLM
110 120 130 140 150
NCITGFGEAS RMTQFKDKSA KQGNDRTTVG LFTYPMLMVA DILLYQADQV
160 170 180 190 200
PVGEDQRQHL ELTRDLADRF NQTYGDAFTV PTAYILKETA KIYDLQDPTA
210 220 230 240 250
KMSKSAATPK GLINLLDEPK ATAKKVKSAV TDTDTVVRFD RETKPGVSNL
260 270 280 290 300
LTIYSTLTGA EIAELERKYE GKGYGALKTD LADVVVEFVT PFRERTRQYL
310 320 330
DDPETLDAIL AKGAEKARSV AAETLARAYD EVGFLPAKH
Length:339
Mass (Da):37,593
Last modified:October 1, 2000 - v1
Checksum:iC45FC36D081D0197
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939121 Genomic DNA. Translation: CAB89058.1.
RefSeqiNP_628994.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB89058; CAB89058; CAB89058.
GeneIDi1100280.
KEGGisco:SCO4839.
PATRICi23739510. VBIStrCoe124346_4915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939121 Genomic DNA. Translation: CAB89058.1 .
RefSeqi NP_628994.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9KZA7.
SMRi Q9KZA7. Positions 8-335.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO4839.

Proteomic databases

PRIDEi Q9KZA7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB89058 ; CAB89058 ; CAB89058 .
GeneIDi 1100280.
KEGGi sco:SCO4839.
PATRICi 23739510. VBIStrCoe124346_4915.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000059940.
InParanoidi Q9KZA7.
KOi K01867.
OMAi IDPKKHI.
OrthoDBi EOG686NJQ.
PhylomeDBi Q9KZA7.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiSYW2_STRCO
AccessioniPrimary (citable) accession number: Q9KZA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3