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Protein

Tryptophan--tRNA ligase 2

Gene

trpS2

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei141L-tryptophanUniRule annotation1
Binding sitei192ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 17ATPUniRule annotation3
Nucleotide bindingi24 – 25ATPUniRule annotation2
Nucleotide bindingi153 – 155ATPUniRule annotation3
Nucleotide bindingi201 – 205ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.1.1.2 5998

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase 2UniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetase 2UniRule annotation
Short name:
TrpRS 2UniRule annotation
Gene namesi
Name:trpS2UniRule annotation
Synonyms:trpS
Ordered Locus Names:SCO4839
ORF Names:SC5G8.07
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366881 – 339Tryptophan--tRNA ligase 2Add BLAST339

Proteomic databases

PRIDEiQ9KZA7

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO4839

Structurei

3D structure databases

ProteinModelPortaliQ9KZA7
SMRiQ9KZA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi16 – 25"HIGH" regionUniRule annotation10
Motifi201 – 205"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059940
InParanoidiQ9KZA7
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9
PhylomeDBiQ9KZA7

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.6202 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KZA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMANERPRV LSGIQPTSGS FHLGNYLGAV RQWVDMQDTH DAFYMVVDLH
60 70 80 90 100
AITVPQDPKE LRENTRVAAA QLLAAGLDPD RCTLFVQSHV PEHAQLGWLM
110 120 130 140 150
NCITGFGEAS RMTQFKDKSA KQGNDRTTVG LFTYPMLMVA DILLYQADQV
160 170 180 190 200
PVGEDQRQHL ELTRDLADRF NQTYGDAFTV PTAYILKETA KIYDLQDPTA
210 220 230 240 250
KMSKSAATPK GLINLLDEPK ATAKKVKSAV TDTDTVVRFD RETKPGVSNL
260 270 280 290 300
LTIYSTLTGA EIAELERKYE GKGYGALKTD LADVVVEFVT PFRERTRQYL
310 320 330
DDPETLDAIL AKGAEKARSV AAETLARAYD EVGFLPAKH
Length:339
Mass (Da):37,593
Last modified:October 1, 2000 - v1
Checksum:iC45FC36D081D0197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939121 Genomic DNA Translation: CAB89058.1
RefSeqiNP_628994.1, NC_003888.3
WP_003974132.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB89058; CAB89058; CAB89058
GeneIDi1100280
29660955
KEGGisco:SCO4839
PATRICifig|100226.15.peg.4915

Similar proteinsi

Entry informationi

Entry nameiSYW2_STRCO
AccessioniPrimary (citable) accession number: Q9KZA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome