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Q9KZA7 (SYW2_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase 2

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase 2
Short name=TrpRS 2
Gene names
Name:trpS2
Synonyms:trpS
Ordered Locus Names:SCO4839
ORF Names:SC5G8.07
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Tryptophan--tRNA ligase 2 HAMAP-Rule MF_00140
PRO_0000136688

Regions

Motif16 – 2510"HIGH" region HAMAP-Rule MF_00140
Motif201 – 2055"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site2041ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KZA7 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: C45FC36D081D0197

FASTA33937,593
        10         20         30         40         50         60 
MSMANERPRV LSGIQPTSGS FHLGNYLGAV RQWVDMQDTH DAFYMVVDLH AITVPQDPKE 

        70         80         90        100        110        120 
LRENTRVAAA QLLAAGLDPD RCTLFVQSHV PEHAQLGWLM NCITGFGEAS RMTQFKDKSA 

       130        140        150        160        170        180 
KQGNDRTTVG LFTYPMLMVA DILLYQADQV PVGEDQRQHL ELTRDLADRF NQTYGDAFTV 

       190        200        210        220        230        240 
PTAYILKETA KIYDLQDPTA KMSKSAATPK GLINLLDEPK ATAKKVKSAV TDTDTVVRFD 

       250        260        270        280        290        300 
RETKPGVSNL LTIYSTLTGA EIAELERKYE GKGYGALKTD LADVVVEFVT PFRERTRQYL 

       310        320        330 
DDPETLDAIL AKGAEKARSV AAETLARAYD EVGFLPAKH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939121 Genomic DNA. Translation: CAB89058.1.
RefSeqNP_628994.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9KZA7.
SMRQ9KZA7. Positions 8-335.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO4839.

Proteomic databases

PRIDEQ9KZA7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB89058; CAB89058; CAB89058.
GeneID1100280.
KEGGsco:SCO4839.
PATRIC23739510. VBIStrCoe124346_4915.

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059940.
KOK01867.
OMAIDPKKHI.
OrthoDBEOG686NJQ.
PhylomeDBQ9KZA7.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW2_STRCO
AccessionPrimary (citable) accession number: Q9KZA7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries