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Q9KYV7 (PNPH_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Purine nucleoside phosphorylase

Short name=PNP
EC=2.4.2.1
Gene names
Ordered Locus Names:SCO3188
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Purine nucleoside phosphorylase involved in purine salvage By similarity. HAMAP-Rule MF_01963

Catalytic activity

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01963

Pathway

Purine metabolism; purine nucleoside salvage. HAMAP-Rule MF_01963

Subunit structure

Homohexamer. Dimer of a homotrimer By similarity. HAMAP-Rule MF_01963

Miscellaneous

Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA By similarity.

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Purine nucleoside phosphorylase HAMAP-Rule MF_01963
PRO_0000415083

Regions

Region55 – 562Phosphate binding By similarity
Region218 – 2203Substrate binding By similarity

Sites

Binding site151Phosphate By similarity
Binding site1941Substrate; via amide nitrogen By similarity
Binding site1951Phosphate By similarity
Site2311Important for substrate specificity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KYV7 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: CA99954C27D27D8A

FASTA28029,755
        10         20         30         40         50         60 
MANKVKAEIG VIGGSGFYSF LDDVTEVRVD TPYGPPSDSL FLGEVAGRRV AFLPRHGRGH 

        70         80         90        100        110        120 
HLPPHRINYR ANLWALRSVG ARQVLGPCAV GGLRPEYGPG TLLVPDQFVD RTRSRPSTYF 

       130        140        150        160        170        180 
DGLPMPDGTV PNVVHVSLAD PYCPTGRAAA LKAARGREWE PVDGGTLVVV EGPRFGTRAE 

       190        200        210        220        230        240 
SLWHRAQGWS VVGMTGHPEA ALARELELCY TSLTLVTDLD AGAESGEGVS HEEVLRVFAA 

       250        260        270        280 
NVDRLRGVLF DAVAALPASG ERDCPCGAAL GGMDPGIALP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939115 Genomic DNA. Translation: CAB90972.1.
RefSeqNP_627402.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9KYV7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO3188.

Proteomic databases

PRIDEQ9KYV7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB90972; CAB90972; CAB90972.
GeneID1098622.
KEGGsco:SCO3188.
PATRIC23736118. VBIStrCoe124346_3248.

Phylogenomic databases

HOGENOMHOG000228987.
KOK00772.
OMACEAQLCY.
OrthoDBEOG6KHFXC.
PhylomeDBQ9KYV7.

Enzyme and pathway databases

UniPathwayUPA00606.

Family and domain databases

Gene3D3.40.50.1580. 1 hit.
HAMAPMF_01963. MTAP.
InterProIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view]
PANTHERPTHR11904. PTHR11904. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMSSF53167. SSF53167. 1 hit.
TIGRFAMsTIGR01694. MTAP. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNPH_STRCO
AccessionPrimary (citable) accession number: Q9KYV7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways