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Q9KYV7

- PNPH_STRCO

UniProt

Q9KYV7 - PNPH_STRCO

Protein

Purine nucleoside phosphorylase

Gene

SCO3188

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Purine nucleoside phosphorylase involved in purine salvage.UniRule annotation

    Catalytic activityi

    Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151PhosphateUniRule annotation
    Binding sitei194 – 1941Substrate; via amide nitrogenUniRule annotation
    Binding sitei195 – 1951PhosphateUniRule annotation
    Sitei231 – 2311Important for substrate specificityUniRule annotation

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. purine-nucleoside phosphorylase activity Source: UniProtKB-EC
    3. S-methyl-5-thioadenosine phosphorylase activity Source: InterPro

    GO - Biological processi

    1. purine ribonucleoside salvage Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    UniPathwayiUPA00606.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Purine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
    Short name:
    PNPUniRule annotation
    Gene namesi
    Ordered Locus Names:SCO3188
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 280280Purine nucleoside phosphorylasePRO_0000415083Add
    BLAST

    Proteomic databases

    PRIDEiQ9KYV7.

    Interactioni

    Subunit structurei

    Homohexamer. Dimer of a homotrimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi100226.SCO3188.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KYV7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni55 – 562Phosphate bindingUniRule annotation
    Regioni218 – 2203Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000228987.
    KOiK00772.
    OMAiCEAQLCY.
    OrthoDBiEOG6KHFXC.
    PhylomeDBiQ9KYV7.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    HAMAPiMF_01963. MTAP.
    InterProiIPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01694. MTAP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9KYV7-1 [UniParc]FASTAAdd to Basket

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    MANKVKAEIG VIGGSGFYSF LDDVTEVRVD TPYGPPSDSL FLGEVAGRRV    50
    AFLPRHGRGH HLPPHRINYR ANLWALRSVG ARQVLGPCAV GGLRPEYGPG 100
    TLLVPDQFVD RTRSRPSTYF DGLPMPDGTV PNVVHVSLAD PYCPTGRAAA 150
    LKAARGREWE PVDGGTLVVV EGPRFGTRAE SLWHRAQGWS VVGMTGHPEA 200
    ALARELELCY TSLTLVTDLD AGAESGEGVS HEEVLRVFAA NVDRLRGVLF 250
    DAVAALPASG ERDCPCGAAL GGMDPGIALP 280
    Length:280
    Mass (Da):29,755
    Last modified:October 1, 2000 - v1
    Checksum:iCA99954C27D27D8A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939115 Genomic DNA. Translation: CAB90972.1.
    RefSeqiNP_627402.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB90972; CAB90972; CAB90972.
    GeneIDi1098622.
    KEGGisco:SCO3188.
    PATRICi23736118. VBIStrCoe124346_3248.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939115 Genomic DNA. Translation: CAB90972.1 .
    RefSeqi NP_627402.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9KYV7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO3188.

    Proteomic databases

    PRIDEi Q9KYV7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB90972 ; CAB90972 ; CAB90972 .
    GeneIDi 1098622.
    KEGGi sco:SCO3188.
    PATRICi 23736118. VBIStrCoe124346_3248.

    Phylogenomic databases

    HOGENOMi HOG000228987.
    KOi K00772.
    OMAi CEAQLCY.
    OrthoDBi EOG6KHFXC.
    PhylomeDBi Q9KYV7.

    Enzyme and pathway databases

    UniPathwayi UPA00606 .

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    HAMAPi MF_01963. MTAP.
    InterProi IPR010044. MTAP.
    IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01694. MTAP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiPNPH_STRCO
    AccessioniPrimary (citable) accession number: Q9KYV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 25, 2012
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3