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Protein

Purine nucleoside phosphorylase

Gene

SCO3188

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Purine nucleoside phosphorylase involved in purine salvage.UniRule annotation

Miscellaneous

Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15PhosphateUniRule annotation1
Binding sitei194Substrate; via amide nitrogenUniRule annotation1
Binding sitei195PhosphateUniRule annotation1
Sitei231Important for substrate specificityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

UniPathwayiUPA00606

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Short name:
PNPUniRule annotation
Gene namesi
Ordered Locus Names:SCO3188
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004150831 – 280Purine nucleoside phosphorylaseAdd BLAST280

Proteomic databases

PRIDEiQ9KYV7

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO3188

Structurei

3D structure databases

ProteinModelPortaliQ9KYV7
SMRiQ9KYV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni55 – 56Phosphate bindingUniRule annotation2
Regioni218 – 220Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107USC Bacteria
COG0005 LUCA
HOGENOMiHOG000228987
InParanoidiQ9KYV7
KOiK00772
OMAiNLYRSWG
OrthoDBiPOG091H0228
PhylomeDBiQ9KYV7

Family and domain databases

HAMAPiMF_01963 MTAP, 1 hit
InterProiView protein in InterPro
IPR010044 MTAP
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
PANTHERiPTHR42679 PTHR42679, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01694 MTAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KYV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKVKAEIG VIGGSGFYSF LDDVTEVRVD TPYGPPSDSL FLGEVAGRRV
60 70 80 90 100
AFLPRHGRGH HLPPHRINYR ANLWALRSVG ARQVLGPCAV GGLRPEYGPG
110 120 130 140 150
TLLVPDQFVD RTRSRPSTYF DGLPMPDGTV PNVVHVSLAD PYCPTGRAAA
160 170 180 190 200
LKAARGREWE PVDGGTLVVV EGPRFGTRAE SLWHRAQGWS VVGMTGHPEA
210 220 230 240 250
ALARELELCY TSLTLVTDLD AGAESGEGVS HEEVLRVFAA NVDRLRGVLF
260 270 280
DAVAALPASG ERDCPCGAAL GGMDPGIALP
Length:280
Mass (Da):29,755
Last modified:October 1, 2000 - v1
Checksum:iCA99954C27D27D8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939115 Genomic DNA Translation: CAB90972.1
RefSeqiNP_627402.1, NC_003888.3
WP_003975629.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB90972; CAB90972; CAB90972
GeneIDi1098622
KEGGisco:SCO3188
PATRICifig|100226.15.peg.3248

Similar proteinsi

Entry informationi

Entry nameiPNPH_STRCO
AccessioniPrimary (citable) accession number: Q9KYV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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