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Q9KYV7

- PNPH_STRCO

UniProt

Q9KYV7 - PNPH_STRCO

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Protein
Purine nucleoside phosphorylase
Gene
SCO3188
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Purine nucleoside phosphorylase involved in purine salvage By similarity.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Phosphate By similarity
Binding sitei194 – 1941Substrate; via amide nitrogen By similarity
Binding sitei195 – 1951Phosphate By similarity
Sitei231 – 2311Important for substrate specificity By similarity

GO - Molecular functioni

  1. S-methyl-5-thioadenosine phosphorylase activity Source: InterPro
  2. phosphorylase activity Source: InterPro
  3. purine-nucleoside phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. purine ribonucleoside salvage Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

UniPathwayiUPA00606.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylase (EC:2.4.2.1)
Short name:
PNP
Gene namesi
Ordered Locus Names:SCO3188
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Purine nucleoside phosphorylaseUniRule annotation
PRO_0000415083Add
BLAST

Proteomic databases

PRIDEiQ9KYV7.

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO3188.

Structurei

3D structure databases

ProteinModelPortaliQ9KYV7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni55 – 562Phosphate binding By similarity
Regioni218 – 2203Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000228987.
KOiK00772.
OMAiCEAQLCY.
OrthoDBiEOG6KHFXC.
PhylomeDBiQ9KYV7.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KYV7-1 [UniParc]FASTAAdd to Basket

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MANKVKAEIG VIGGSGFYSF LDDVTEVRVD TPYGPPSDSL FLGEVAGRRV    50
AFLPRHGRGH HLPPHRINYR ANLWALRSVG ARQVLGPCAV GGLRPEYGPG 100
TLLVPDQFVD RTRSRPSTYF DGLPMPDGTV PNVVHVSLAD PYCPTGRAAA 150
LKAARGREWE PVDGGTLVVV EGPRFGTRAE SLWHRAQGWS VVGMTGHPEA 200
ALARELELCY TSLTLVTDLD AGAESGEGVS HEEVLRVFAA NVDRLRGVLF 250
DAVAALPASG ERDCPCGAAL GGMDPGIALP 280
Length:280
Mass (Da):29,755
Last modified:October 1, 2000 - v1
Checksum:iCA99954C27D27D8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939115 Genomic DNA. Translation: CAB90972.1.
RefSeqiNP_627402.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB90972; CAB90972; CAB90972.
GeneIDi1098622.
KEGGisco:SCO3188.
PATRICi23736118. VBIStrCoe124346_3248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939115 Genomic DNA. Translation: CAB90972.1 .
RefSeqi NP_627402.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9KYV7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO3188.

Proteomic databases

PRIDEi Q9KYV7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB90972 ; CAB90972 ; CAB90972 .
GeneIDi 1098622.
KEGGi sco:SCO3188.
PATRICi 23736118. VBIStrCoe124346_3248.

Phylogenomic databases

HOGENOMi HOG000228987.
KOi K00772.
OMAi CEAQLCY.
OrthoDBi EOG6KHFXC.
PhylomeDBi Q9KYV7.

Enzyme and pathway databases

UniPathwayi UPA00606 .

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiPNPH_STRCO
AccessioniPrimary (citable) accession number: Q9KYV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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