Reviewed, UniProtKB/Swiss-Prot Q9KY56 (SUCC1_STRCO)

Names and origin

Protein names

Recommended name:
    Succinyl-CoA ligase [ADP-forming] subunit beta-1
    EC=6.2.1.5
Alternative name(s):
    Succinyl-CoA synthetase subunit beta-1
      Short name=SCS-beta-1

Gene names

Name:	sucC1
Ordered Locus Names:	SCO4808
ORF Names:	SCD63A.19

Organism

Streptomyces coelicolor [Complete proteome] [HAMAP]

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. HAMAP MF_00558
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle. HAMAP MF_00558
Subunit structure	Heterotetramer of two alpha and two beta subunits By similarity.
Sequence similarities	Belongs to the succinate/malate CoA ligase beta subunit family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Succinyl-CoA ligase [ADP-forming] subunit beta-1 HAMAP MF_00558		PRO_0000102869
Regions
	Domain	9 – 237	229	ATP-grasp
	Nucleotide binding	35 – 101	67	ATP By similarity
Sites
	Metal binding	190	1	Magnesium or manganese By similarity
	Metal binding	192	1	Magnesium or manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9KY56-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 14839C3E479D2783	FASTA	394	41,602
	10 20 30 40 50 60 MDLFEYQARD LFAKHDVPVL AGEVIDTPEA AREITERLGG KSVVKAQVKV GGRGKAGGVK 70 80 90 100 110 120 LAASADEAVA RATDILGMDI KGHTVHKVMI AETAPEIVEE YYVSFLLDRA NRTFLSIASV 130 140 150 160 170 180 EGGVEIEEVA ATRPEAVAKT PIDAIDGVTP EKAREIVEAA KFPAEVADKV ADILVKLWDT 190 200 210 220 230 240 FIKEDALLVE VNPLAKVVSG DVIALDGKVS LDDNAEFRHP DFEALHDKAA ANPLEAAAKE 250 260 270 280 290 300 KNLNYVKLDG EVGIIGNGAG LVMSTLDVVA YAGEAHGNVK PANFLDIGGG ASAQVMANGL 310 320 330 340 350 360 EIILGDPDVR SVFVNVFGGI TACDEVANGI VQALKLLEDR GEKVEKPLVV RLDGNNAELG 370 380 390 RKILTDANHP LVQRVDTMDG AADKAAELAH AAAK

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL939121 Genomic DNA. Translation: CAB92671.1.
RefSeq	NP_628965.1.
3D structure databases
HSSP	HSSP built from PDB template 1JKJ based on UniProtKB P07460.
ModBase	Search...
Genome annotation databases
GeneID	1100249.
GenomeReviews	Gene locus SCO4808 in contig AL645882_GR.
KEGG	sco:SCO4808.
NMPDR	fig|100226.1.peg.4763.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9KY56.
OMA	Q9KY56. NLHCLDA.
Enzyme and pathway databases
BioCyc	SCOE100226:SCO4808-MON.
BRENDA	6.2.1.5. 1084.
Family and domain databases
HAMAP	MF_00558. [Tree]
InterPro	IPR011761. ATP-grasp. IPR013650. ATP-grasp_succ-CoA_synth-type. IPR013816. ATP_grasp_subdomain_2. IPR005811. CoA_ligase. IPR017866. Succ-CoA_synthase_bsu_CS. IPR005809. Succ_CoA_synthase_bsu. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.261. Succinyl-CoA_synth-like. 1 hit.
PANTHER	PTHR11815. CoA_lig_beta. 1 hit.
Pfam	PF08442. ATP-grasp_2. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01016. sucCoAbeta. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. PS01217. SUCCINYL_COA_LIG_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUCC1_STRCO

Accession

Primary (citable) accession number: Q9KY56

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)