sucD

Functionⁱ

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.UniRule annotation

Catalytic activityⁱ

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation

Pathwayⁱ: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes succinate from succinyl-CoA (ligase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:

Succinate--CoA ligase [ADP-forming] subunit beta 1 (sucC1), Succinate--CoA ligase [ADP-forming] subunit alpha (sucD), Succinate--CoA ligase [ADP-forming] subunit alpha (sucD), Succinate--CoA ligase [ADP-forming] subunit beta 2 (sucC2)

This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinate from succinyl-CoA (ligase route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	43	Coenzyme AUniRule annotation	1
Binding siteⁱ	165	Substrate; shared with subunit betaUniRule annotation	1
Active siteⁱ	251	Tele-phosphohistidine intermediateUniRule annotation	1

GO - Molecular functionⁱ

cofactor binding Source: InterPro
nucleotide binding Source: UniProtKB-KW
succinate-CoA ligase (ADP-forming) activity Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

tricarboxylic acid cycle Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	LigaseUniRule annotation
Biological process	Tricarboxylic acid cycleUniRule annotation
Ligand	Nucleotide-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayⁱ	UPA00223; UER00999.

UniPathwayⁱ

UPA00223; UER00999.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Succinate--CoA ligase [ADP-forming] subunit alphaUniRule annotation (EC:6.2.1.5UniRule annotation) Alternative name(s): Succinyl-CoA synthetase subunit alphaUniRule annotation Short name: SCS-alphaUniRule annotation
Gene namesⁱ	Name:sucDUniRule annotation Ordered Locus Names:SCO4809Imported
Organismⁱ	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)Imported
Taxonomic identifierⁱ	100226 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Actinobacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces › Streptomyces albidoflavus group › Streptomyces coelicolor
Proteomesⁱ	UP000001973 Componentⁱ: Chromosome

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	Q9KY55.

PRIDEⁱ

Q9KY55.

Interactionⁱ

Subunit structureⁱ

Heterotetramer of two alpha and two beta subunits.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	100226.SCO4809.

STRINGⁱ

100226.SCO4809.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9KY55.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 104	CoA_bindingInterPro annotationAdd BLAST		101

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	17 – 20	Coenzyme A bindingUniRule annotation		4
Regionⁱ	100 – 102	Coenzyme A bindingUniRule annotation		3

Sequence similaritiesⁱ

Belongs to the succinate/malate CoA ligase alpha subunit family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105CH8. Bacteria. COG0074. LUCA.
HOGENOMⁱ	HOG000239685.
InParanoidⁱ	Q9KY55.
KEGG Orthology (KO) More...KOⁱ	K01902.
OMAⁱ	IIFVPPA.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H04FK.
PhylomeDBⁱ	Q9KY55.

Family and domain databases

Gene3Dⁱ	3.40.50.261. 1 hit.
HAMAPⁱ	MF_01988. Succ_CoA_alpha. 1 hit.
InterProⁱ	View protein in InterPro IPR017440. Cit_synth/succinyl-CoA_lig_AS. IPR033847. Citrt_syn/SCS-alpha_CS. IPR003781. CoA-bd. IPR005810. CoA_lig_alpha. IPR005811. CoA_ligase. IPR036291. NAD(P)-bd_dom_sf. IPR016102. Succinyl-CoA_synth-like.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02629. CoA_binding. 1 hit. PF00549. Ligase_CoA. 1 hit.
PIRSFⁱ	PIRSF001553. SucCS_alpha. 1 hit.
SMARTⁱ	View protein in SMART SM00881. CoA_binding. 1 hit.
SUPFAMⁱ	SSF51735. SSF51735. 1 hit. SSF52210. SSF52210. 1 hit.
TIGRFAMsⁱ	TIGR01019. sucCoAalpha. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01216. SUCCINYL_COA_LIG_1. 1 hit. PS00399. SUCCINYL_COA_LIG_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9KY55-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAIWLNKDSK VIVQGMTGAT GMKHTKLMLG DGTEVVGGVN PRKAGTSVDF 
        60         70         80         90        100
DGNEVPVFGT VKEAIEKTGA NVSVIFVPEK FTKDAVVEAI DAEIPLAVVI 
       110        120        130        140        150
TEGIAVHDSA AFWSYAGKKG NKTRIIGPNC PGIITPGQSN VGIIPGDITK 
       160        170        180        190        200
PGRIGLVSKS GTLTYQMMYE LRDIGFSTAV GIGGDPIIGT THIDALAAFE 
       210        220        230        240        250
ADPETDLIVM IGEIGGDAEE RAAEYISKNV TKPVVGYVAG FTAPEGKTMG 
       260        270        280        290 
HAGAIVSGSS GTAQAKKEAL EAAGVKVGKT PTETAKLARA ILAG

Length:294

Mass (Da):30,239

Last modified:October 1, 2000 - v1

Checksum:ⁱECD4DC830CAE8F09

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL939121 Genomic DNA. Translation: CAB92672.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_628966.1. NC_003888.3. WP_003974163.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaⁱ	CAB92672; CAB92672; CAB92672.
GeneIDⁱ	1100250. 29660612.
KEGGⁱ	sco:SCO4809.
PATRICⁱ	fig\|100226.15.peg.4886.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9KY55	A0A0K2AXB3 A0A1H2CQ58 D6ECR4 A0A1R1WJ05	Streptomyces ambofaciens ATCC 23877 Streptomyces sp. 2114.2 Streptomyces lividans TK24 Streptomyces sp. M1013	294	UniRef100_A0A0K2AXB3	Cluster: Succinate--CoA ligase [ADP-forming] subunit alpha	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9KY55	A0A0F7VV65 A0A0L0JZX7 A0A0K2AXB3 A0A1H2CQ58 D6ECR4 A0A1R1WJ05 A0A117QL83 A0A0N1IRX4 A0A209BVR6 A0A1H5C5W3 +47	Streptomyces leeuwenhoekii Streptomyces acidiscabies Streptomyces ambofaciens ATCC 23877 Streptomyces sp. 2114.2 Streptomyces lividans TK24 Streptomyces sp. M1013 Streptomyces longwoodensis Streptomyces sp. NRRL F-7442 Streptomyces sp. CS113 Streptomyces sp. 2231.1 And more	294	UniRef90_A0A0F7VV65	Cluster: Succinate--CoA ligase [ADP-forming] subunit alpha	58

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9KY55	A0A0F7VV65 UPI0007504DEE A0A0S2P4F8 A0A101QIB4 H2JUI6 S5UVW1 UPI00046603B5 A0A117QL83 UPI0004C1956D A0A1S6J874 +139	Streptomyces leeuwenhoekii Streptomyces canus Streptomyces hygroscopicus subsp. limoneus Streptomyces corchorusii (Streptomyces chibaensis) Streptomyces hygroscopicus subsp. jinggangensis (strain 5008) Streptomyces collinus (strain DSM 40733 / Tu 365) Streptomyces sp. CNH189 Streptomyces longwoodensis Streptomyces sp. NRRL S-1022 Streptomyces pactum And more	294	UniRef50_A0A0F7VV65	Cluster: Succinate--CoA ligase [ADP-forming] subunit alpha	150

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL939121 Genomic DNA. Translation: CAB92672.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_628966.1. NC_003888.3. WP_003974163.1. NC_003888.3.

3D structure databases

ProteinModelPortalⁱ	Q9KY55.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	100226.SCO4809.

STRINGⁱ

100226.SCO4809.

Proteomic databases

PRIDEⁱ	Q9KY55.

PRIDEⁱ

Q9KY55.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	CAB92672; CAB92672; CAB92672.
GeneIDⁱ	1100250. 29660612.
KEGGⁱ	sco:SCO4809.
PATRICⁱ	fig\|100226.15.peg.4886.

Phylogenomic databases

eggNOGⁱ	ENOG4105CH8. Bacteria. COG0074. LUCA.
HOGENOMⁱ	HOG000239685.
InParanoidⁱ	Q9KY55.
KEGG Orthology (KO) More...KOⁱ	K01902.
OMAⁱ	IIFVPPA.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H04FK.
PhylomeDBⁱ	Q9KY55.

Enzyme and pathway databases

UniPathwayⁱ	UPA00223; UER00999.

UniPathwayⁱ

UPA00223; UER00999.

Family and domain databases

Gene3Dⁱ	3.40.50.261. 1 hit.
HAMAPⁱ	MF_01988. Succ_CoA_alpha. 1 hit.
InterProⁱ	View protein in InterPro IPR017440. Cit_synth/succinyl-CoA_lig_AS. IPR033847. Citrt_syn/SCS-alpha_CS. IPR003781. CoA-bd. IPR005810. CoA_lig_alpha. IPR005811. CoA_ligase. IPR036291. NAD(P)-bd_dom_sf. IPR016102. Succinyl-CoA_synth-like.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02629. CoA_binding. 1 hit. PF00549. Ligase_CoA. 1 hit.
PIRSFⁱ	PIRSF001553. SucCS_alpha. 1 hit.
SMARTⁱ	View protein in SMART SM00881. CoA_binding. 1 hit.
SUPFAMⁱ	SSF51735. SSF51735. 1 hit. SSF52210. SSF52210. 1 hit.
TIGRFAMsⁱ	TIGR01019. sucCoAalpha. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01216. SUCCINYL_COA_LIG_1. 1 hit. PS00399. SUCCINYL_COA_LIG_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q9KY55_STRCO
Accessionⁱ	Q9KY55Primary (citable) accession number: Q9KY55
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 1, 2000
	Last sequence update:	October 1, 2000
	Last modified:	March 28, 2018
	This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9KY55 (Q9KY55_STRCO)

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Succinate--CoA ligase [ADP-forming] subunit alpha

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tricarboxylic acid cycle

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: tricarboxylic acid cycle

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ