UniProtKB - Q9KY55 (Q9KY55_STRCO)
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Protein
Succinate--CoA ligase [ADP-forming] subunit alpha
Gene
sucD
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Functioni
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.UniRule annotation
Catalytic activityi
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation
: tricarboxylic acid cycle Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes succinate from succinyl-CoA (ligase route).UniRule annotationProteins known to be involved in this subpathway in this organism are:
- Succinate--CoA ligase [ADP-forming] subunit beta 1 (sucC1), Succinate--CoA ligase [ADP-forming] subunit alpha (sucD), Succinate--CoA ligase [ADP-forming] subunit alpha (sucD), Succinate--CoA ligase [ADP-forming] subunit beta 2 (sucC2)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes succinate from succinyl-CoA (ligase route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 43 | Coenzyme AUniRule annotation | 1 | |
Binding sitei | 165 | Substrate; shared with subunit betaUniRule annotation | 1 | |
Active sitei | 251 | Tele-phosphohistidine intermediateUniRule annotation | 1 |
GO - Molecular functioni
- cofactor binding Source: InterPro
- nucleotide binding Source: UniProtKB-KW
- succinate-CoA ligase (ADP-forming) activity Source: UniProtKB-UniRule
GO - Biological processi
- tricarboxylic acid cycle Source: UniProtKB-UniRule
Keywordsi
Molecular function | LigaseUniRule annotation |
Biological process | Tricarboxylic acid cycleUniRule annotation |
Ligand | Nucleotide-bindingUniRule annotation |
Enzyme and pathway databases
UniPathwayi | UPA00223; UER00999. |
Names & Taxonomyi
Protein namesi | Recommended name: Succinate--CoA ligase [ADP-forming] subunit alphaUniRule annotation (EC:6.2.1.5UniRule annotation)Alternative name(s): Succinyl-CoA synthetase subunit alphaUniRule annotation Short name: SCS-alphaUniRule annotation |
Gene namesi | Name:sucDUniRule annotation Ordered Locus Names:SCO4809Imported |
Organismi | Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)Imported |
Taxonomic identifieri | 100226 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces › Streptomyces albidoflavus group › |
Proteomesi |
|
Interactioni
Subunit structurei
Heterotetramer of two alpha and two beta subunits.UniRule annotation
Protein-protein interaction databases
STRINGi | 100226.SCO4809. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 104 | CoA_bindingInterPro annotationAdd BLAST | 101 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 17 – 20 | Coenzyme A bindingUniRule annotation | 4 | |
Regioni | 100 – 102 | Coenzyme A bindingUniRule annotation | 3 |
Sequence similaritiesi
Belongs to the succinate/malate CoA ligase alpha subunit family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105CH8. Bacteria. COG0074. LUCA. |
HOGENOMi | HOG000239685. |
InParanoidi | Q9KY55. |
KOi | K01902. |
OMAi | IIFVPPA. |
OrthoDBi | POG091H04FK. |
PhylomeDBi | Q9KY55. |
Family and domain databases
Gene3Di | 3.40.50.261. 1 hit. |
HAMAPi | MF_01988. Succ_CoA_alpha. 1 hit. |
InterProi | View protein in InterPro IPR017440. Cit_synth/succinyl-CoA_lig_AS. IPR033847. Citrt_syn/SCS-alpha_CS. IPR003781. CoA-bd. IPR005810. CoA_lig_alpha. IPR005811. CoA_ligase. IPR036291. NAD(P)-bd_dom_sf. IPR016102. Succinyl-CoA_synth-like. |
Pfami | View protein in Pfam PF02629. CoA_binding. 1 hit. PF00549. Ligase_CoA. 1 hit. |
PIRSFi | PIRSF001553. SucCS_alpha. 1 hit. |
SMARTi | View protein in SMART SM00881. CoA_binding. 1 hit. |
SUPFAMi | SSF51735. SSF51735. 1 hit. SSF52210. SSF52210. 1 hit. |
TIGRFAMsi | TIGR01019. sucCoAalpha. 1 hit. |
PROSITEi | View protein in PROSITE PS01216. SUCCINYL_COA_LIG_1. 1 hit. PS00399. SUCCINYL_COA_LIG_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q9KY55-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAIWLNKDSK VIVQGMTGAT GMKHTKLMLG DGTEVVGGVN PRKAGTSVDF
60 70 80 90 100
DGNEVPVFGT VKEAIEKTGA NVSVIFVPEK FTKDAVVEAI DAEIPLAVVI
110 120 130 140 150
TEGIAVHDSA AFWSYAGKKG NKTRIIGPNC PGIITPGQSN VGIIPGDITK
160 170 180 190 200
PGRIGLVSKS GTLTYQMMYE LRDIGFSTAV GIGGDPIIGT THIDALAAFE
210 220 230 240 250
ADPETDLIVM IGEIGGDAEE RAAEYISKNV TKPVVGYVAG FTAPEGKTMG
260 270 280 290
HAGAIVSGSS GTAQAKKEAL EAAGVKVGKT PTETAKLARA ILAG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL939121 Genomic DNA. Translation: CAB92672.1. |
RefSeqi | NP_628966.1. NC_003888.3. WP_003974163.1. NC_003888.3. |
Genome annotation databases
EnsemblBacteriai | CAB92672; CAB92672; CAB92672. |
GeneIDi | 1100250. 29660612. |
KEGGi | sco:SCO4809. |
PATRICi | fig|100226.15.peg.4886. |
Similar proteinsi
Entry informationi
Entry namei | Q9KY55_STRCO | |
Accessioni | Q9KY55Primary (citable) accession number: Q9KY55 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 1, 2000 |
Last sequence update: | October 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |