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Q9KY50 (PUR9_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:SCO4814
ORF Names:SCD63A.25
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 523523Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192132

Sequences

Sequence LengthMass (Da)Tools
Q9KY50 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 10A16ADA490E350F

FASTA52355,043
        10         20         30         40         50         60 
MTATAGSNKR AIRRALVSVY DKTGLEDLAR GLHEAGVELV STGSTAGRIA AAGVPVTKVE 

        70         80         90        100        110        120 
ELTGFPECLD GRVKTLHPKV HAGILADLRL ESHRQQLDEL GVAPFDLVVV NLYPFRETVA 

       130        140        150        160        170        180 
SGATPDECVE QIDIGGPSMV RAAAKNHPSV AVVTSPARYA DVLLAVEGGG FDLAARKRLA 

       190        200        210        220        230        240 
AEAFQHTAAY DVAVASWFAA EYAPVDESGF PDFLGATYER ANTLRYGENP HQPAALYTSP 

       250        260        270        280        290        300 
EGGGLAQAEQ LHGKEMSYNN YTDTDAARRA AYDHAEPCVA IIKHANPCGI AIGADVAEAH 

       310        320        330        340        350        360 
RKAHDCDPVS AYGGVIAVNR PVSKEMAERV AGIFTEVIVA PDYEDGALEA LTKKKNIRVL 

       370        380        390        400        410        420 
RAPAAPAAPV EVKPIDGGAL LQVTDRLQAE GDDPATWTLA TGEALSEAEL AELAFAWRAC 

       430        440        450        460        470        480 
RAVKSNAILL AKDGASVGVG MGQVNRVDSA KLAVERAGAE RAQGAYAASD AFFPFPDGLE 

       490        500        510        520 
ILTGAGVKAV VQPGGSVRDE LVVEAAKKAG VTMYFTGTRH FFH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939121 Genomic DNA. Translation: CAB92677.1.
RefSeqNP_628971.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9KY50.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO4814.

Proteomic databases

PRIDEQ9KY50.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB92677; CAB92677; CAB92677.
GeneID1100255.
KEGGsco:SCO4814.
PATRIC23739462. VBIStrCoe124346_4891.

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.
PhylomeDBQ9KY50.

Enzyme and pathway databases

UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_STRCO
AccessionPrimary (citable) accession number: Q9KY50
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways