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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:SCO4814
ORF Names:SCD63A.25
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Bifunctional purine biosynthesis protein PurHPRO_0000192132Add
BLAST

Proteomic databases

PRIDEiQ9KY50.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4814.

Structurei

3D structure databases

ProteinModelPortaliQ9KY50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
InParanoidiQ9KY50.
KOiK00602.
OMAiPCGVAEG.
OrthoDBiEOG6QCDFF.
PhylomeDBiQ9KY50.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KY50-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTATAGSNKR AIRRALVSVY DKTGLEDLAR GLHEAGVELV STGSTAGRIA
60 70 80 90 100
AAGVPVTKVE ELTGFPECLD GRVKTLHPKV HAGILADLRL ESHRQQLDEL
110 120 130 140 150
GVAPFDLVVV NLYPFRETVA SGATPDECVE QIDIGGPSMV RAAAKNHPSV
160 170 180 190 200
AVVTSPARYA DVLLAVEGGG FDLAARKRLA AEAFQHTAAY DVAVASWFAA
210 220 230 240 250
EYAPVDESGF PDFLGATYER ANTLRYGENP HQPAALYTSP EGGGLAQAEQ
260 270 280 290 300
LHGKEMSYNN YTDTDAARRA AYDHAEPCVA IIKHANPCGI AIGADVAEAH
310 320 330 340 350
RKAHDCDPVS AYGGVIAVNR PVSKEMAERV AGIFTEVIVA PDYEDGALEA
360 370 380 390 400
LTKKKNIRVL RAPAAPAAPV EVKPIDGGAL LQVTDRLQAE GDDPATWTLA
410 420 430 440 450
TGEALSEAEL AELAFAWRAC RAVKSNAILL AKDGASVGVG MGQVNRVDSA
460 470 480 490 500
KLAVERAGAE RAQGAYAASD AFFPFPDGLE ILTGAGVKAV VQPGGSVRDE
510 520
LVVEAAKKAG VTMYFTGTRH FFH
Length:523
Mass (Da):55,043
Last modified:October 1, 2000 - v1
Checksum:i10A16ADA490E350F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939121 Genomic DNA. Translation: CAB92677.1.
RefSeqiNP_628971.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB92677; CAB92677; CAB92677.
GeneIDi1100255.
KEGGisco:SCO4814.
PATRICi23739462. VBIStrCoe124346_4891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939121 Genomic DNA. Translation: CAB92677.1.
RefSeqiNP_628971.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9KY50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO4814.

Proteomic databases

PRIDEiQ9KY50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB92677; CAB92677; CAB92677.
GeneIDi1100255.
KEGGisco:SCO4814.
PATRICi23739462. VBIStrCoe124346_4891.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
InParanoidiQ9KY50.
KOiK00602.
OMAiPCGVAEG.
OrthoDBiEOG6QCDFF.
PhylomeDBiQ9KY50.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiPUR9_STRCO
AccessioniPrimary (citable) accession number: Q9KY50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.