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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional purine biosynthesis protein PurH (purH)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Multifunctional enzyme, Transferase
Biological processPurine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00133
UPA00074; UER00135

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:SCO4814
ORF Names:SCD63A.25
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001921321 – 523Bifunctional purine biosynthesis protein PurHAdd BLAST523

Proteomic databases

PRIDEiQ9KY50

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO4814

Structurei

3D structure databases

ProteinModelPortaliQ9KY50
SMRiQ9KY50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 154MGS-likePROSITE-ProRule annotationAdd BLAST154

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DC1 Bacteria
COG0138 LUCA
HOGENOMiHOG000230373
InParanoidiQ9KY50
KOiK00602
OMAiDLLFAWK
OrthoDBiPOG091H00UT
PhylomeDBiQ9KY50

Family and domain databases

Gene3Di3.40.140.20, 2 hits
3.40.50.1380, 1 hit
HAMAPiMF_00139 PurH, 1 hit
InterProiView protein in InterPro
IPR024051 AICAR_Tfase_dup_dom_sf
IPR016193 Cytidine_deaminase-like
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
IPR002695 PurH-like
PANTHERiPTHR11692 PTHR11692, 1 hit
PfamiView protein in Pfam
PF01808 AICARFT_IMPCHas, 1 hit
PF02142 MGS, 1 hit
PIRSFiPIRSF000414 AICARFT_IMPCHas, 1 hit
SMARTiView protein in SMART
SM00798 AICARFT_IMPCHas, 1 hit
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
SSF53927 SSF53927, 1 hit
TIGRFAMsiTIGR00355 purH, 1 hit
PROSITEiView protein in PROSITE
PS51855 MGS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KY50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATAGSNKR AIRRALVSVY DKTGLEDLAR GLHEAGVELV STGSTAGRIA
60 70 80 90 100
AAGVPVTKVE ELTGFPECLD GRVKTLHPKV HAGILADLRL ESHRQQLDEL
110 120 130 140 150
GVAPFDLVVV NLYPFRETVA SGATPDECVE QIDIGGPSMV RAAAKNHPSV
160 170 180 190 200
AVVTSPARYA DVLLAVEGGG FDLAARKRLA AEAFQHTAAY DVAVASWFAA
210 220 230 240 250
EYAPVDESGF PDFLGATYER ANTLRYGENP HQPAALYTSP EGGGLAQAEQ
260 270 280 290 300
LHGKEMSYNN YTDTDAARRA AYDHAEPCVA IIKHANPCGI AIGADVAEAH
310 320 330 340 350
RKAHDCDPVS AYGGVIAVNR PVSKEMAERV AGIFTEVIVA PDYEDGALEA
360 370 380 390 400
LTKKKNIRVL RAPAAPAAPV EVKPIDGGAL LQVTDRLQAE GDDPATWTLA
410 420 430 440 450
TGEALSEAEL AELAFAWRAC RAVKSNAILL AKDGASVGVG MGQVNRVDSA
460 470 480 490 500
KLAVERAGAE RAQGAYAASD AFFPFPDGLE ILTGAGVKAV VQPGGSVRDE
510 520
LVVEAAKKAG VTMYFTGTRH FFH
Length:523
Mass (Da):55,043
Last modified:October 1, 2000 - v1
Checksum:i10A16ADA490E350F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939121 Genomic DNA Translation: CAB92677.1
RefSeqiNP_628971.1, NC_003888.3
WP_011029883.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB92677; CAB92677; CAB92677
GeneIDi1100255
KEGGisco:SCO4814
PATRICifig|100226.15.peg.4891

Similar proteinsi

Entry informationi

Entry nameiPUR9_STRCO
AccessioniPrimary (citable) accession number: Q9KY50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health