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Q9KXS0

- KGUA_STRCO

UniProt

Q9KXS0 - KGUA_STRCO

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Protein
Guanylate kinase
Gene
gmk, SCO1479, SC9C5.03c
Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP By similarity.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. guanylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:SCO1479
ORF Names:SC9C5.03c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Guanylate kinaseUniRule annotation
PRO_0000170615Add
BLAST

Proteomic databases

PRIDEiQ9KXS0.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO1479.

Structurei

3D structure databases

ProteinModelPortaliQ9KXS0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 197181Guanylate kinase-like
Add
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037640.
KOiK00942.
OMAiDAVFSIS.
OrthoDBiEOG6CP410.
PhylomeDBiQ9KXS0.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KXS0-1 [UniParc]FASTAAdd to Basket

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MAATPRGTSP VPPDARPRLT VLSGPSGVGK STVVAHMRKE HPEVWLSVSA    50
TTRRPRPGEQ HGVHYFFVSD EEMDKLIANG ELLEWAEFAG NRYGTPRTAV 100
LERLEAGEPV LLEIDLQGAR QVRESMPEAR LVFLAPPSWD ELVRRLTGRG 150
TEPPEVIERR LAAAKVELAA EPEFDQTLVN TSVEDVAREL LALTNVV 197
Length:197
Mass (Da):21,734
Last modified:October 1, 2000 - v1
Checksum:i318741E08824DC53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939109 Genomic DNA. Translation: CAB93359.1.
RefSeqiNP_625759.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB93359; CAB93359; CAB93359.
GeneIDi1096905.
KEGGisco:SCO1479.
PATRICi23732534. VBIStrCoe124346_1488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939109 Genomic DNA. Translation: CAB93359.1 .
RefSeqi NP_625759.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9KXS0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO1479.

Proteomic databases

PRIDEi Q9KXS0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB93359 ; CAB93359 ; CAB93359 .
GeneIDi 1096905.
KEGGi sco:SCO1479.
PATRICi 23732534. VBIStrCoe124346_1488.

Phylogenomic databases

eggNOGi COG0194.
HOGENOMi HOG000037640.
KOi K00942.
OMAi DAVFSIS.
OrthoDBi EOG6CP410.
PhylomeDBi Q9KXS0.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00328. Guanylate_kinase.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiKGUA_STRCO
AccessioniPrimary (citable) accession number: Q9KXS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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