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Q9KXR8

- PYRF_STRCO

UniProt

Q9KXR8 - PYRF_STRCO

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei96 – 961Proton donorBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:SCO1481
ORF Names:SC9C5.05c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Orotidine 5'-phosphate decarboxylasePRO_0000134634Add
BLAST

Proteomic databases

PRIDEiQ9KXR8.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO1481.

Structurei

3D structure databases

ProteinModelPortaliQ9KXR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245748.
KOiK01591.
OMAiGSTMGAY.
OrthoDBiEOG6DZF33.
PhylomeDBiQ9KXR8.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KXR8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPFGARLRR AMDERGPLCV GIDPHASLLA EWGLNDDVAG LERFSRTVVE
60 70 80 90 100
AMADRVAVLK PQSAFFERFG SRGVAVLETT VQEARAAGAL VVMDAKRGDI
110 120 130 140 150
GSTMAAYAES FLHKDAPLFS DALTVSPYLG YGSLKPAVDL ARESGAGLFV
160 170 180 190 200
LALTSNPEGG EVQHAVRGDG RSVGATMLAH LAAENAGEEP LGSFGAVVGA
210 220 230 240 250
TLGDLSSYDL GINGPLLAPG IGAQGATPAD LPRVFGAALR NVVPNVSRGV
260 270
LRHGPDVTAL RTAADRFAVE IRTAVTAS
Length:278
Mass (Da):28,791
Last modified:October 1, 2000 - v1
Checksum:i9B3574E71E21FDC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939109 Genomic DNA. Translation: CAB93361.1.
RefSeqiNP_625761.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB93361; CAB93361; CAB93361.
GeneIDi1096907.
KEGGisco:SCO1481.
PATRICi23732538. VBIStrCoe124346_1490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939109 Genomic DNA. Translation: CAB93361.1 .
RefSeqi NP_625761.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9KXR8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO1481.

Proteomic databases

PRIDEi Q9KXR8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB93361 ; CAB93361 ; CAB93361 .
GeneIDi 1096907.
KEGGi sco:SCO1481.
PATRICi 23732538. VBIStrCoe124346_1490.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245748.
KOi K01591.
OMAi GSTMGAY.
OrthoDBi EOG6DZF33.
PhylomeDBi Q9KXR8.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiPYRF_STRCO
AccessioniPrimary (citable) accession number: Q9KXR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3