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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:SCO1481
ORF Names:SC9C5.05c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346341 – 278Orotidine 5'-phosphate decarboxylaseAdd BLAST278

Proteomic databases

PRIDEiQ9KXR8

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO1481

Structurei

3D structure databases

ProteinModelPortaliQ9KXR8
SMRiQ9KXR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105SKN Bacteria
COG0284 LUCA
HOGENOMiHOG000245748
KOiK01591
OMAiQSAFFER
OrthoDBiPOG091H09O1
PhylomeDBiQ9KXR8

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01215 OMPdecase_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR018089 OMPdecase_AS
IPR011995 OMPdecase_type-2
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR43375 PTHR43375, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02127 pyrF_sub2, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KXR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPFGARLRR AMDERGPLCV GIDPHASLLA EWGLNDDVAG LERFSRTVVE
60 70 80 90 100
AMADRVAVLK PQSAFFERFG SRGVAVLETT VQEARAAGAL VVMDAKRGDI
110 120 130 140 150
GSTMAAYAES FLHKDAPLFS DALTVSPYLG YGSLKPAVDL ARESGAGLFV
160 170 180 190 200
LALTSNPEGG EVQHAVRGDG RSVGATMLAH LAAENAGEEP LGSFGAVVGA
210 220 230 240 250
TLGDLSSYDL GINGPLLAPG IGAQGATPAD LPRVFGAALR NVVPNVSRGV
260 270
LRHGPDVTAL RTAADRFAVE IRTAVTAS
Length:278
Mass (Da):28,791
Last modified:October 1, 2000 - v1
Checksum:i9B3574E71E21FDC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939109 Genomic DNA Translation: CAB93361.1
RefSeqiNP_625761.1, NC_003888.3
WP_011027809.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB93361; CAB93361; CAB93361
GeneIDi1096907
KEGGisco:SCO1481
PATRICifig|100226.15.peg.1490

Similar proteinsi

Entry informationi

Entry nameiPYRF_STRCO
AccessioniPrimary (citable) accession number: Q9KXR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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