Q9KXQ4 (AROC_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Synonyms:	aroF
Ordered Locus Names:	SCO1496
ORF Names:	SC9C5.20c

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Chorismate synthase HAMAP MF_00300		PRO_0000140653

Sequences

	Sequence		Length	Mass (Da)
	Q9KXQ4 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 4603A034A35174B8	FASTA	394	41,577
	10 20 30 40 50 60 MSRLRWLTAG ESHGPALVAT LEGLPAGVPI TTEMVADHLA RRRLGYGRGA RMKFERDEVT 70 80 90 100 110 120 FLGGVRHGLT MGSPVAVMVG NTEWPKWEQV MAADPVDPEV LAGLARNAPL TRPRPGHADL 130 140 150 160 170 180 AGMQKYGFDE ARPILERASA RETAARVALG AVARSYLKET AGVEIVSHVV ELASAKAPHG 190 200 210 220 230 240 VYPTPADVER LDADPVRCLD ADASKAMVAE IDQAHKDGDT LGGVVEVLAY GVPVGLGSHV 250 260 270 280 290 300 HWDRKLDARL AGALMGIQAI KGVEIGDGFE LARVPGSRAH DEIVGTPDGI RRVSGRSGGT 310 320 330 340 350 360 EGGLTTGELL RVRAAMKPIA TVPRALKTVD VATGEAAQAH HQRSDVSAVP AAGIVAEAMV 370 380 390 ALVLADAVAE KFGGDSVTET RRNVRSYLDN LDIR

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939109 Genomic DNA. Translation: CAB93376.1.
RefSeq	NP_625776.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9KXQ4.
SMR	Q9KXQ4. Positions 4-387.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1096922.
GenomeReviews	Gene locus SCO1496 in contig AL645882_GR.
KEGG	sco:SCO1496.
NMPDR	fig|100226.1.peg.1463.
PATRIC	23732568. VBIStrCoe124346_1505.
Phylogenomic databases
HOGENOM	HBG292336.
OMA	IQTITEN.
PhylomeDB	Q9KXQ4.
ProtClustDB	PRK05382.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_STRCO

Accession

Primary (citable) accession number: Q9KXQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program