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Protein

Guanylate kinase

Gene

gmk

Organism
Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 26ATPBy similarity8

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMGAL710127:GC09-714-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:MYCGA6400
ORF Names:MGA_0462
OrganismiMycoplasma gallisepticum (strain R(low / passage 15 / clone 2))
Taxonomic identifieri710127 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000001418 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001705611 – 195Guanylate kinaseAdd BLAST195

Proteomic databases

PRIDEiQ9KX62.

Structurei

3D structure databases

ProteinModelPortaliQ9KX62.
SMRiQ9KX62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 191Guanylate kinase-likeAdd BLAST180

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

HOGENOMiHOG000037639.
KOiK00942.
OMAiYGTLKSE.

Family and domain databases

HAMAPiMF_00328. Guanylate_kinase. 1 hit.
InterProiView protein in InterPro
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00625. Guanylate_kin. 1 hit.
SMARTiView protein in SMART
SM00072. GuKc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiView protein in PROSITE
PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KX62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVIYIMSNK QGLIILISGP SGVGKGTIVS RLLSDNNLKL NVSISATTRK
60 70 80 90 100
KRASEVEGVH YFFKTKEEFE QMIANNQLLE YANYVNNYYG TPLSLVKEIL
110 120 130 140 150
DKNENLILEI EYQGVIQVLR KGFRTLSIFV LPPSEDELVA RLKKRGTEND
160 170 180 190
EVIKHRLEQA VKEYAHRELY DHTIINDDLE KTIEDIKQLI LKYNQ
Length:195
Mass (Da):22,473
Last modified:August 15, 2003 - v2
Checksum:i6AB0B0FBF9A66573
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120R → K in AAF36761 (Ref. 1) Curated1
Sequence conflicti191L → R in AAF36761 (Ref. 1) Curated1
Sequence conflicti194N → S in AAF36761 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35043 Genomic DNA. Translation: AAF36761.1.
AE015450 Genomic DNA. Translation: AAP56990.1.
RefSeqiWP_011113900.1. NC_004829.2.

Genome annotation databases

EnsemblBacteriaiAAP56990; AAP56990; MGA_0462.
GeneIDi1089945.
KEGGimga:MGA_0462.
PATRICifig|233150.7.peg.717.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKGUA_MYCGA
AccessioniPrimary (citable) accession number: Q9KX62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 15, 2003
Last modified: June 7, 2017
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families