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Protein

DNA-directed RNA polymerase subunit beta'

Gene

rpoC

Organism
Thermus aquaticus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit beta'UniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit beta'UniRule annotation
Alternative name(s):
RNA polymerase subunit beta'UniRule annotation
Transcriptase subunit beta'UniRule annotation
Gene namesi
Name:rpoCUniRule annotation
OrganismiThermus aquaticus
Taxonomic identifieri271 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15241524DNA-directed RNA polymerase subunit beta'PRO_0000067817Add
BLAST

Proteomic databases

PRIDEiQ9KWU6.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

STRINGi498848.TaqDRAFT_4914.

Structurei

Secondary structure

1
1524
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 93Combined sources
Helixi15 – 217Combined sources
Beta strandi23 – 253Combined sources
Beta strandi34 – 363Combined sources
Beta strandi41 – 433Combined sources
Turni47 – 493Combined sources
Beta strandi53 – 575Combined sources
Beta strandi66 – 683Combined sources
Beta strandi74 – 763Combined sources
Helixi83 – 875Combined sources
Beta strandi91 – 944Combined sources
Helixi103 – 1064Combined sources
Beta strandi107 – 1093Combined sources
Turni111 – 1133Combined sources
Turni115 – 1173Combined sources
Turni118 – 1225Combined sources
Helixi125 – 1273Combined sources
Beta strandi128 – 1314Combined sources
Beta strandi136 – 1383Combined sources
Beta strandi142 – 1465Combined sources
Helixi150 – 1534Combined sources
Helixi155 – 1628Combined sources
Beta strandi166 – 1705Combined sources
Beta strandi190 – 1945Combined sources
Beta strandi198 – 22629Combined sources
Turni227 – 2293Combined sources
Beta strandi234 – 2363Combined sources
Beta strandi241 – 2444Combined sources
Beta strandi249 – 2524Combined sources
Beta strandi257 – 2648Combined sources
Beta strandi267 – 2748Combined sources
Beta strandi277 – 2848Combined sources
Beta strandi286 – 2883Combined sources
Beta strandi307 – 3126Combined sources
Beta strandi317 – 32711Combined sources
Beta strandi330 – 34617Combined sources
Beta strandi359 – 3613Combined sources
Beta strandi366 – 3694Combined sources
Helixi373 – 3753Combined sources
Beta strandi380 – 40223Combined sources
Beta strandi420 – 4223Combined sources
Helixi424 – 4263Combined sources
Beta strandi433 – 4386Combined sources
Turni439 – 4424Combined sources
Beta strandi443 – 4486Combined sources
Helixi458 – 4669Combined sources
Helixi470 – 47910Combined sources
Turni480 – 4823Combined sources
Beta strandi484 – 4874Combined sources
Turni488 – 4914Combined sources
Helixi492 – 50312Combined sources
Beta strandi504 – 5063Combined sources
Turni509 – 5124Combined sources
Beta strandi515 – 5195Combined sources
Helixi522 – 5243Combined sources
Beta strandi528 – 5303Combined sources
Turni531 – 5333Combined sources
Beta strandi534 – 5363Combined sources
Helixi540 – 55314Combined sources
Turni554 – 5596Combined sources
Helixi564 – 58320Combined sources
Beta strandi586 – 5883Combined sources
Beta strandi594 – 5963Combined sources
Turni603 – 6075Combined sources
Beta strandi608 – 6158Combined sources
Helixi616 – 6194Combined sources
Beta strandi622 – 6287Combined sources
Beta strandi630 – 6334Combined sources
Beta strandi636 – 6416Combined sources
Helixi646 – 66318Combined sources
Helixi670 – 6756Combined sources
Turni676 – 6783Combined sources
Beta strandi679 – 6813Combined sources
Helixi685 – 69511Combined sources
Beta strandi700 – 7034Combined sources
Helixi710 – 7123Combined sources
Beta strandi713 – 7175Combined sources
Beta strandi721 – 7288Combined sources
Helixi730 – 7323Combined sources
Helixi733 – 7364Combined sources
Turni740 – 7423Combined sources
Beta strandi746 – 7483Combined sources
Helixi753 – 76210Combined sources
Helixi765 – 7673Combined sources
Beta strandi772 – 7798Combined sources
Helixi785 – 7928Combined sources
Helixi813 – 8219Combined sources
Beta strandi822 – 8254Combined sources
Beta strandi827 – 8293Combined sources
Beta strandi831 – 8333Combined sources
Helixi836 – 8405Combined sources
Beta strandi842 – 8454Combined sources
Helixi846 – 8549Combined sources
Beta strandi860 – 8623Combined sources
Beta strandi865 – 8684Combined sources
Beta strandi871 – 8733Combined sources
Helixi877 – 88812Combined sources
Turni889 – 8913Combined sources
Helixi893 – 8997Combined sources
Helixi908 – 92114Combined sources
Helixi924 – 94421Combined sources
Helixi951 – 9533Combined sources
Helixi960 – 98021Combined sources
Beta strandi981 – 9833Combined sources
Helixi985 – 101329Combined sources
Beta strandi1016 – 10183Combined sources
Helixi1019 – 10257Combined sources
Beta strandi1026 – 10294Combined sources
Helixi1032 – 10398Combined sources
Beta strandi1043 – 10464Combined sources
Beta strandi1052 – 10576Combined sources
Helixi1067 – 10726Combined sources
Turni1073 – 10753Combined sources
Helixi1076 – 108712Combined sources
Beta strandi1090 – 10923Combined sources
Helixi1093 – 110210Combined sources
Beta strandi1118 – 11258Combined sources
Turni1127 – 11293Combined sources
Beta strandi1132 – 11343Combined sources
Helixi1137 – 11448Combined sources
Beta strandi1148 – 11514Combined sources
Beta strandi1153 – 11553Combined sources
Beta strandi1158 – 11603Combined sources
Helixi1168 – 117912Combined sources
Beta strandi1184 – 11896Combined sources
Turni1191 – 11933Combined sources
Beta strandi1197 – 11993Combined sources
Turni1203 – 12053Combined sources
Beta strandi1209 – 12135Combined sources
Helixi1221 – 123010Combined sources
Helixi1231 – 12333Combined sources
Helixi1255 – 12639Combined sources
Beta strandi1269 – 12713Combined sources
Beta strandi1276 – 12783Combined sources
Beta strandi1279 – 12846Combined sources
Beta strandi1286 – 12883Combined sources
Beta strandi1291 – 12955Combined sources
Beta strandi1300 – 13045Combined sources
Beta strandi1324 – 13263Combined sources
Beta strandi1328 – 13303Combined sources
Helixi1332 – 135928Combined sources
Helixi1365 – 137410Combined sources
Beta strandi1377 – 13837Combined sources
Beta strandi1385 – 13873Combined sources
Beta strandi1392 – 13943Combined sources
Helixi1395 – 14028Combined sources
Turni1403 – 14097Combined sources
Beta strandi1416 – 14194Combined sources
Helixi1424 – 14296Combined sources
Beta strandi1430 – 14323Combined sources
Helixi1434 – 14385Combined sources
Helixi1443 – 145210Combined sources
Helixi1462 – 14687Combined sources
Helixi1475 – 14773Combined sources
Turni1479 – 14835Combined sources
Beta strandi1485 – 14884Combined sources
Helixi1490 – 14967Combined sources
Turni1497 – 14993Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HQMX-ray3.30D1-1524[»]
1I6VX-ray3.30D1-1524[»]
1L9UX-ray4.00D/M1-1524[»]
1L9ZX-ray6.50D1-1524[»]
1YNJX-ray3.20D/J1-1524[»]
1YNNX-ray3.30D/J1-1524[»]
2AUJX-ray2.70D151-455[»]
2GHOX-ray5.00D1-158[»]
D452-1524[»]
4XLNX-ray4.00D/J1-1524[»]
4XLPX-ray4.00D/J1-1524[»]
4XLQX-ray4.60D/J1-1524[»]
4XLRX-ray4.30D/J1-1524[»]
4XLSX-ray4.01D/J1-1524[»]
ProteinModelPortaliQ9KWU6.
SMRiQ9KWU6. Positions 3-1240, 1253-1501.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9KWU6.

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D27. Bacteria.
COG0086. LUCA.

Family and domain databases

HAMAPiMF_01322. RNApol_bact_RpoC. 1 hit.
InterProiIPR012754. DNA-dir_RpoC_beta_prime.
IPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
[Graphical view]
PfamiPF04997. RNA_pol_Rpb1_1. 2 hits.
PF00623. RNA_pol_Rpb1_2. 1 hit.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 2 hits.
[Graphical view]
SMARTiSM00663. RPOLA_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KWU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKEVRKVRI ALASPEKIRS WSYGEVEKPE TINYRTLKPE RDGLFDERIF
60 70 80 90 100
GPIKDYECAC GKYKRQRFEG KVCERCGVEV TRSIVRRYRM GHIELATPAA
110 120 130 140 150
HIWFVKDVPS KIGTLLDLSA TELEQVLYFN KYIVLDPKGA VLDGVPVEKR
160 170 180 190 200
QLLTDEEYRE LRYGKQETYP LPAGVDALVK DGEEVVKGQE LAPGVVSRMD
210 220 230 240 250
GVALYRFPRR VRVDYLRKER AALRIPLSAW VEKEAYRPGE VLAELSEPYL
260 270 280 290 300
FRAEESGVVE LKDLAEGHLI YLRQEEEVVA RYFLPAGMTP LVVEGEIVEV
310 320 330 340 350
GQPLAEGKGL LRLPRHMTAK EVEAEEEGDS VHLTLFLEWT EPKDYKVAPH
360 370 380 390 400
MNVIVPEGAK VQAGEKIVAA IDPEEEVIAE AEGVVHLHEP ASILVVKARV
410 420 430 440 450
YPFEDDVEVT TGDRVAPGDV LADGGKVKSE IYGRVEVDLV RNVVRVVESY
460 470 480 490 500
DIDARMGAEA IQELLKELDL EKLERELLEE MKHPSRARRA KARKRLEVVR
510 520 530 540 550
AFLDSGNRPE WMILEAVPVL PPDLRPMVQV DGGRFATSDL NDLYRRLINR
560 570 580 590 600
NNRLKKLLAQ GAPEIIIRNE KRMLQEAVDA VIDNGRRGSP VTNPGSERPL
610 620 630 640 650
RSLTDILSGK QGRFRQNLLG KRVDYSGRSV IVVGPQLKLH QCGLPKRMAL
660 670 680 690 700
ELFKPFLLKK MEEKAFAPNV KAARRMLERQ RDIKDEVWDA LEEVIHGKVV
710 720 730 740 750
LLNRAPTLHR LGIQAFQPVL VEGQSIQLHP LVCEAFNADF DGDQMAVHVP
760 770 780 790 800
LSSFAQAEAR IQMLSAHNLL SPASGEPLAK PSRDIILGLY YITQVRKEKK
810 820 830 840 850
GAGMAFATPE EALAAYERGE VALNAPIVVA GRETSVGRLK FVFANPDEAL
860 870 880 890 900
LAVAHGLLDL QDVVTVRYLG RRLETSPGRI LFARIVGEAV GDEKVAQELI
910 920 930 940 950
QMDVPQEKNS LKDLVYQAFL RLGMEKTARL LDALKYYGFT LSTTSGITIG
960 970 980 990 1000
IDDAVIPEEK QRYLEEADRK LRQIEQAYEM GFLTDRERYD QVIQLWTETT
1010 1020 1030 1040 1050
EKVTQAVFKN FEENYPFNPL YVMAQSGARG NPQQIRQLCG MRGLMQKPSG
1060 1070 1080 1090 1100
ETFEVPVRSS FREGLTVLEY FISSHGARKG GADTALRTAD SGYLTRKLVD
1110 1120 1130 1140 1150
VAHEIVVREA DCGTTNYISV PLFQMDEVTR TLRLRKRSDI ESGLYGRVLA
1160 1170 1180 1190 1200
REVEALGRRL EEGRYLSLED VHFLIKAAEA GEVREVPVRS PLTCQTRYGV
1210 1220 1230 1240 1250
CQKCYGYDLS MARPVSIGEA VGVVAAESIG EPGTQLTMRT FHTGGVAVGT
1260 1270 1280 1290 1300
DITQGLPRVI ELFEARRPKA KAVISEIDGV VRIEEGEDRL SVFVESEGFS
1310 1320 1330 1340 1350
KEYKLPKDAR LLVKDGDYVE AGQPLTRGAI DPHQLLEAKG PEAVERYLVD
1360 1370 1380 1390 1400
EIQKVYRAQG VKLHDKHIEI VVRQMLKYVE VTDPGDSRLL EGQVLEKWDV
1410 1420 1430 1440 1450
EALNERLIAE GKVPVAWKPL LMGVTKSALS TKSWLSAASF QNTTHVLTEA
1460 1470 1480 1490 1500
AIAGKKDELI GLKENVILGR LIPAGTGSDF VRFTQVVDQR TLKAIEEARK
1510 1520
EAVEAKEKEA PRRPVRREQP GKGL
Length:1,524
Mass (Da):170,944
Last modified:March 1, 2001 - v2
Checksum:i2720C58615070B7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19223 Genomic DNA. Translation: CAB65466.3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19223 Genomic DNA. Translation: CAB65466.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HQMX-ray3.30D1-1524[»]
1I6VX-ray3.30D1-1524[»]
1L9UX-ray4.00D/M1-1524[»]
1L9ZX-ray6.50D1-1524[»]
1YNJX-ray3.20D/J1-1524[»]
1YNNX-ray3.30D/J1-1524[»]
2AUJX-ray2.70D151-455[»]
2GHOX-ray5.00D1-158[»]
D452-1524[»]
4XLNX-ray4.00D/J1-1524[»]
4XLPX-ray4.00D/J1-1524[»]
4XLQX-ray4.60D/J1-1524[»]
4XLRX-ray4.30D/J1-1524[»]
4XLSX-ray4.01D/J1-1524[»]
ProteinModelPortaliQ9KWU6.
SMRiQ9KWU6. Positions 3-1240, 1253-1501.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi498848.TaqDRAFT_4914.

Proteomic databases

PRIDEiQ9KWU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105D27. Bacteria.
COG0086. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ9KWU6.

Family and domain databases

HAMAPiMF_01322. RNApol_bact_RpoC. 1 hit.
InterProiIPR012754. DNA-dir_RpoC_beta_prime.
IPR000722. RNA_pol_asu.
IPR006592. RNA_pol_N.
IPR007080. RNA_pol_Rpb1_1.
IPR007066. RNA_pol_Rpb1_3.
IPR007083. RNA_pol_Rpb1_4.
IPR007081. RNA_pol_Rpb1_5.
[Graphical view]
PfamiPF04997. RNA_pol_Rpb1_1. 2 hits.
PF00623. RNA_pol_Rpb1_2. 1 hit.
PF04983. RNA_pol_Rpb1_3. 1 hit.
PF05000. RNA_pol_Rpb1_4. 1 hit.
PF04998. RNA_pol_Rpb1_5. 2 hits.
[Graphical view]
SMARTiSM00663. RPOLA_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPOC_THEAQ
AccessioniPrimary (citable) accession number: Q9KWU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.