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Q9KWS1

- ACDH_PSESP

UniProt

Q9KWS1 - ACDH_PSESP

Protein

Acetaldehyde dehydrogenase

Gene

amnH

Organism
Pseudomonas sp.
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of 2-aminophenol.1 Publication

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei131 – 1311Acyl-thioester intermediateBy similarity
    Binding sitei290 – 2901NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 164NADBy similarity
    Nucleotide bindingi162 – 1709NADBy similarity

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase (EC:1.2.1.10)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]
    Gene namesi
    Name:amnH
    OrganismiPseudomonas sp.
    Taxonomic identifieri306 [NCBI]
    Taxonomic lineageiBacteriaProteobacteria

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Acetaldehyde dehydrogenasePRO_0000383027Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KWS1.
    SMRiQ9KWS1. Positions 3-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.Curated

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9KWS1-1 [UniParc]FASTAAdd to Basket

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    MSDDRLSVAI IGSGNIGTDL MIKIMRNSKL LKVGAMVGID PKSDGLARAQ    50
    RLGVPTTAEG VDGLLDMPAF RDIKIAFDAT SAGAQAIHNQ KLQAHGVRVI 100
    DLTPAAIGPY VIPVVNFDQH VDAPNINMVT CGGQATIPIV HAVSKVSPVH 150
    YAEIVASISS KSAGPGTRAN IDEFTETTSK AILEVGGAAQ GRAIIILNPA 200
    EPPLIMRDTV YCFVSAEANI DAITDSVEQM VKSVQEYVPG YRLKQKVQFE 250
    KIVAGNEQNI PGLGWSTGLK VSVFLEVEGA GHYLPSYAGN LDIMTSAGLT 300
    VAERIAGSGV QVGGLK 316
    Length:316
    Mass (Da):33,170
    Last modified:October 1, 2000 - v1
    Checksum:i1A709C936C057242
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020521 Genomic DNA. Translation: BAB03537.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020521 Genomic DNA. Translation: BAB03537.1 .

    3D structure databases

    ProteinModelPortali Q9KWS1.
    SMRi Q9KWS1. Positions 3-308.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Novel genes encoding 2-aminophenol 1,6-dioxygenase from Pseudomonas species AP-3 growing on 2-aminophenol and catalytic properties of the purified enzyme."
      Takenaka S., Murakami S., Shinke R., Hatakeyama K., Yukawa H., Aoki K.
      J. Biol. Chem. 272:14727-14732(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
      Strain: AP-3.
    2. "Complete nucleotide sequence and functional analysis of the genes for 2-aminophenol metabolism from Pseudomonas sp. AP-3."
      Takenaka S., Murakami S., Kim Y.J., Aoki K.
      Arch. Microbiol. 174:265-272(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: AP-3.

    Entry informationi

    Entry nameiACDH_PSESP
    AccessioniPrimary (citable) accession number: Q9KWS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3