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Q9KVZ8 (MTX1_XANVA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Modification methylase XhoI

Short name=M.XhoI
EC=2.1.1.72
Alternative name(s):
Adenine-specific methyltransferase XhoI
OrganismXanthomonas vasicola
Taxonomic identifier56459 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length546 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This methylase recognizes the double-stranded sequence CTCGAG, causes specific methylation on A-5 on both strands, and protects the DNA from cleavage by the XhoI endonuclease.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 546546Modification methylase XhoI
PRO_0000087984

Sequences

Sequence LengthMass (Da)Tools
Q9KVZ8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: D9EF9B9D4E137BD2

FASTA54661,025
        10         20         30         40         50         60 
MPDERGAIFT RREVVEFILD LVGYTEDRDL AQTKLLEPSA GHADFLLPII GRLVRSYVAH 

        70         80         90        100        110        120 
GGDLTRGAQT LGPAIRAYEV HESSLETARS VVVAELLRLG VKKAAADGLG RTWLVRADFL 

       130        140        150        160        170        180 
MAPLPHTFDF VVGNPPYVRQ ELIPAVLLAR YRARFKTLYD RADLYIPFYE RCLDVLAPGG 

       190        200        210        220        230        240 
RLGFICTDRW TKNKYGGPLR AMVSEEFSLT HFVDLVDTQA FLSNVMTYPA ITVIERPKPK 

       250        260        270        280        290        300 
SKARPTRVAY RPAISAEVFG PLAKAMTGTK LNHKAGVVEM SGVVNGSEPW ILHQADRLAL 

       310        320        330        340        350        360 
VRRLEETLPT LEEAGCKVGI GVATGNDGVY IGDMKTLNVE PSRKLPLART QDLRGGSIDW 

       370        380        390        400        410        420 
QGKGVLNPFE EDGQVVDLAS YPKFAAYLQE HAIQIKARHV AKKNPERWFR TIDRIYPALA 

       430        440        450        460        470        480 
KTPKLLVPDI KGDAHIVYEE GKLYPHHNLY FITANEWDLR ALQAVLMSGV ARLFVGTYST 

       490        500        510        520        530        540 
TMRGGFLRFQ AQYLRRIRVP HWKNVPKPLQ KALREAAVAG DREAANRATY QLYGLNEAER 


DIVATV 

« Hide

References

[1]"Nucleotide sequences of the XhoI methylase and endonuclease genes."
Morita M., Sugino Y.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 13461 / XH 3 / LMG 7416.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB046567 Genomic DNA. Translation: BAB03596.1.

3D structure databases

ProteinModelPortalQ9KVZ8.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

REBASE3530. M.XhoI.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR011639. RM_methylase_Eco57I.
IPR025931. TaqI_C.
[Graphical view]
PfamPF07669. Eco57I. 1 hit.
PF12950. TaqI_C. 1 hit.
[Graphical view]
PRINTSPR00507. N12N6MTFRASE.
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTX1_XANVA
AccessionPrimary (citable) accession number: Q9KVZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Restriction enzymes and methylases

Classification of restriction enzymes and methylases and list of entries