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Q9KVZ8

- MTX1_XANVA

UniProt

Q9KVZ8 - MTX1_XANVA

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Protein

Modification methylase XhoI

Gene
N/A
Organism
Xanthomonas vasicola
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence CTCGAG, causes specific methylation on A-5 on both strands, and protects the DNA from cleavage by the XhoI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3530. M.XhoI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase XhoI (EC:2.1.1.72)
Short name:
M.XhoI
Alternative name(s):
Adenine-specific methyltransferase XhoI
OrganismiXanthomonas vasicola
Taxonomic identifieri56459 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 546546Modification methylase XhoIPRO_0000087984Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9KVZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.Curated

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR011639. RM_methylase_Eco57I.
IPR029063. SAM-dependent_MTases-like.
IPR025931. TaqI_C.
[Graphical view]
PfamiPF07669. Eco57I. 1 hit.
PF12950. TaqI_C. 1 hit.
[Graphical view]
PRINTSiPR00507. N12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KVZ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPDERGAIFT RREVVEFILD LVGYTEDRDL AQTKLLEPSA GHADFLLPII
60 70 80 90 100
GRLVRSYVAH GGDLTRGAQT LGPAIRAYEV HESSLETARS VVVAELLRLG
110 120 130 140 150
VKKAAADGLG RTWLVRADFL MAPLPHTFDF VVGNPPYVRQ ELIPAVLLAR
160 170 180 190 200
YRARFKTLYD RADLYIPFYE RCLDVLAPGG RLGFICTDRW TKNKYGGPLR
210 220 230 240 250
AMVSEEFSLT HFVDLVDTQA FLSNVMTYPA ITVIERPKPK SKARPTRVAY
260 270 280 290 300
RPAISAEVFG PLAKAMTGTK LNHKAGVVEM SGVVNGSEPW ILHQADRLAL
310 320 330 340 350
VRRLEETLPT LEEAGCKVGI GVATGNDGVY IGDMKTLNVE PSRKLPLART
360 370 380 390 400
QDLRGGSIDW QGKGVLNPFE EDGQVVDLAS YPKFAAYLQE HAIQIKARHV
410 420 430 440 450
AKKNPERWFR TIDRIYPALA KTPKLLVPDI KGDAHIVYEE GKLYPHHNLY
460 470 480 490 500
FITANEWDLR ALQAVLMSGV ARLFVGTYST TMRGGFLRFQ AQYLRRIRVP
510 520 530 540
HWKNVPKPLQ KALREAAVAG DREAANRATY QLYGLNEAER DIVATV
Length:546
Mass (Da):61,025
Last modified:October 1, 2000 - v1
Checksum:iD9EF9B9D4E137BD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046567 Genomic DNA. Translation: BAB03596.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046567 Genomic DNA. Translation: BAB03596.1 .

3D structure databases

ProteinModelPortali Q9KVZ8.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 3530. M.XhoI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR002052. DNA_methylase_N6_adenine_CS.
IPR002296. N12N6_MeTrfase.
IPR011639. RM_methylase_Eco57I.
IPR029063. SAM-dependent_MTases-like.
IPR025931. TaqI_C.
[Graphical view ]
Pfami PF07669. Eco57I. 1 hit.
PF12950. TaqI_C. 1 hit.
[Graphical view ]
PRINTSi PR00507. N12N6MTFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS00092. N6_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequences of the XhoI methylase and endonuclease genes."
    Morita M., Sugino Y.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13461 / XH 3 / LMG 7416.

Entry informationi

Entry nameiMTX1_XANVA
AccessioniPrimary (citable) accession number: Q9KVZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3