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Q9KVZ8

- MTX1_XANVA

UniProt

Q9KVZ8 - MTX1_XANVA

Protein

Modification methylase XhoI

Gene
N/A
Organism
Xanthomonas vasicola
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence CTCGAG, causes specific methylation on A-5 on both strands, and protects the DNA from cleavage by the XhoI endonuclease.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3530. M.XhoI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase XhoI (EC:2.1.1.72)
    Short name:
    M.XhoI
    Alternative name(s):
    Adenine-specific methyltransferase XhoI
    OrganismiXanthomonas vasicola
    Taxonomic identifieri56459 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 546546Modification methylase XhoIPRO_0000087984Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KVZ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR011639. RM_methylase_Eco57I.
    IPR029063. SAM-dependent_MTases-like.
    IPR025931. TaqI_C.
    [Graphical view]
    PfamiPF07669. Eco57I. 1 hit.
    PF12950. TaqI_C. 1 hit.
    [Graphical view]
    PRINTSiPR00507. N12N6MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KVZ8-1 [UniParc]FASTAAdd to Basket

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    MPDERGAIFT RREVVEFILD LVGYTEDRDL AQTKLLEPSA GHADFLLPII    50
    GRLVRSYVAH GGDLTRGAQT LGPAIRAYEV HESSLETARS VVVAELLRLG 100
    VKKAAADGLG RTWLVRADFL MAPLPHTFDF VVGNPPYVRQ ELIPAVLLAR 150
    YRARFKTLYD RADLYIPFYE RCLDVLAPGG RLGFICTDRW TKNKYGGPLR 200
    AMVSEEFSLT HFVDLVDTQA FLSNVMTYPA ITVIERPKPK SKARPTRVAY 250
    RPAISAEVFG PLAKAMTGTK LNHKAGVVEM SGVVNGSEPW ILHQADRLAL 300
    VRRLEETLPT LEEAGCKVGI GVATGNDGVY IGDMKTLNVE PSRKLPLART 350
    QDLRGGSIDW QGKGVLNPFE EDGQVVDLAS YPKFAAYLQE HAIQIKARHV 400
    AKKNPERWFR TIDRIYPALA KTPKLLVPDI KGDAHIVYEE GKLYPHHNLY 450
    FITANEWDLR ALQAVLMSGV ARLFVGTYST TMRGGFLRFQ AQYLRRIRVP 500
    HWKNVPKPLQ KALREAAVAG DREAANRATY QLYGLNEAER DIVATV 546
    Length:546
    Mass (Da):61,025
    Last modified:October 1, 2000 - v1
    Checksum:iD9EF9B9D4E137BD2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046567 Genomic DNA. Translation: BAB03596.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046567 Genomic DNA. Translation: BAB03596.1 .

    3D structure databases

    ProteinModelPortali Q9KVZ8.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 3530. M.XhoI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR002052. DNA_methylase_N6_adenine_CS.
    IPR002296. N12N6_MeTrfase.
    IPR011639. RM_methylase_Eco57I.
    IPR029063. SAM-dependent_MTases-like.
    IPR025931. TaqI_C.
    [Graphical view ]
    Pfami PF07669. Eco57I. 1 hit.
    PF12950. TaqI_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00507. N12N6MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequences of the XhoI methylase and endonuclease genes."
      Morita M., Sugino Y.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 13461 / XH 3 / LMG 7416.

    Entry informationi

    Entry nameiMTX1_XANVA
    AccessioniPrimary (citable) accession number: Q9KVZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3