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Q9KVW0 (ILVD_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase
Short name=DAD
EC=4.2.1.9
Gene names
Name:ilvD
Ordered Locus Names:VC_0028
OrganismVibrio cholerae
Taxonomic identifier666 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length613 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012

Cofactor

Binds 1 4Fe-4S cluster Potential.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012

Sequence similarities

Belongs to the IlvD/Edd family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 613613Dihydroxy-acid dehydratase HAMAP MF_00012
PRO_0000103525

Sites

Metal binding1221Iron-sulfur (4Fe-4S) Potential
Metal binding1951Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9KVW0 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: BC91039D37F3EA7D

FASTA61365,437
        10         20         30         40         50         60 
MPKYRSATTT HGRNMAGARA LWRATGVKEE DFGKPIIAVV NSFTQFVPGH VHLKDLGQLV 

        70         80         90        100        110        120 
AREIEAAGGI AKEFNTIAVD DGIAMGHGGM LYSLPSRELI ADSVEYMVNA HCADAMVCIS 

       130        140        150        160        170        180 
NCDKITPGML MAAMRLNIPA IFVSGGPMEA GKTKLSDQII KLDLVDAMMQ GADPKVSDAQ 

       190        200        210        220        230        240 
SEQIERSACP TCGSCSGMFT ANSMNCLTEA LGLSQPGNGS LLATHADRKQ LFLTAGQRIV 

       250        260        270        280        290        300 
ELTKRYYEQD DASVLPRNIA NKAAFENAIA LDIAMGGSTN TVLHLLAAAQ EGEVEFDMTD 

       310        320        330        340        350        360 
IDRMSRQVPH LCKVAPSTQK YHMEDVHRAG GVMGILGELQ RAGLLKDQTR TVLGISLQEQ 

       370        380        390        400        410        420 
LAQYDVKQTQ DPAVHTMFRA GPAGIRTTQA FSQDCRWDTL DDDRQEGCIR DKAHAFSQDG 

       430        440        450        460        470        480 
GLAVLKGNLA IDGCIVKTAG VDESILKFRG PAVVYESQED AVNGILGGQV KAGDVVVIRY 

       490        500        510        520        530        540 
EGPKGGPGMQ EMLYPTTYLK SMGLGKQCAL LTDGRFSGGT SGLSIGHASP EAANGGTIGL 

       550        560        570        580        590        600 
VRSGDSIAID IPNRSITLEV SESELAARRA EQDKLGWKPV DRQRTVSLAL KAYASMATSA 

       610 
DKGAVRDKSK LEG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE003852 Genomic DNA. Translation: AAF93206.1.
PIRF82374.
RefSeqNP_229687.1. NC_002505.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2612960.
GenomeReviewsGene locus VC_0028 in contig AE003852_GR.
KEGGvch:VC0028.
PATRIC20079104. VBIVibCho83274_0027.
TIGRVC_0028.

Phylogenomic databases

HOGENOMHBG671001.
OMASQDCRWP.
PhylomeDBQ9KVW0.
ProtClustDBPRK12448.

Family and domain databases

HAMAPMF_00012. IlvD.
[Tree]
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
KOK01687.
PANTHERPTHR21000. ILVD_EDD_family. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00110. IlvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVD_VIBCH
AccessionPrimary (citable) accession number: Q9KVW0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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