Q9KVV7 (Q9KVV7_VIBCH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetolactate synthase RuleBase RU003591
EC=2.2.1.6 RuleBase RU003591

Gene names

Ordered Locus Names:

VC_0031

Organism

Vibrio cholerae

Taxonomic identifier

666 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 pyruvate = 2-acetolactate + CO2. RuleBase RU003591
Cofactor	Binds 1 magnesium ion per subunit By similarity. RuleBase RU003591 Binds 1 thiamine pyrophosphate per subunit By similarity. RuleBase RU003591
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4. RuleBase RU003591 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4. RuleBase RU003591
Sequence similarities	Belongs to the TPP enzyme family. RuleBase RU003702

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis RuleBase RU003591
Ligand	Magnesium RuleBase RU003591 Metal-binding RuleBase RU003591 Thiamine pyrophosphate RuleBase RU003591
Molecular function	Transferase RuleBase RU003591
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	branched chain family amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acetolactate synthase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9KVV7 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 5849A696B8A5C719	FASTA	548	59,074
	10 20 30 40 50 60 MTGAQLVVAA LKQQGIKTVF GYPGGAIMPI YDALYDGGVE HILCRHEQGA AMAAIGMARS 70 80 90 100 110 120 TQKVAVCMAT SGPGATNLVT GLADAFLDSV PLVAITGQVA SSHIGTDAFQ EMDVIGMSLS 130 140 150 160 170 180 CTKHSYLVTD INELAPTLAE AFEVAQTGRP GPVLVDIAKD VQLGKAPVSA LPSFTPPAMP 190 200 210 220 230 240 HVDATHLANA QALLAQSKRP VLYVGGGVQL ANATDTVREF LRLNPMPSVS TLKGLGTIER 250 260 270 280 290 300 HDPHYLGMLG MHGTKAANLI VQECDLLIAV GARFDDRVTG KLDTFAPHAK VIHVDIDAAE 310 320 330 340 350 360 FNKLRHAHAA LRGDINLILP QLELSHDISP WVHHSESLRS GFKWRYDHPG DNIFAPLLLK 370 380 390 400 410 420 QLSDMMPDSS IVSTDVGQHQ MWAAQHIQPR APQNFISSAG LGTMGFGLPA AMGAAVARPD 430 440 450 460 470 480 DQSILISGDG SFMMNVQELG TLKRRQIPVK MVLLDNQRLG MVRQWQSLFF DGRHSETILD 490 500 510 520 530 540 DNPDFVMLAK AFNIPGKTIS RKEEVEPALR EMLASKTAYL LHVLIDEEEN VWPLVPPGAS NTDMLENT

References

[1]

"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae." Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S. , Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M. Nature 406:477-483(2000) [PubMed: 10952301] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39315 / El Tor Inaba N16961 / Serotype O1.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE003852 Genomic DNA. Translation: AAF93209.1.
PIR	A82375.
RefSeq	NP_229690.1. NC_002505.1.
3D structure databases
HSSP	HSSP built from PDB template 1JSC based on UniProtKB P07342.
ProteinModelPortal	Q9KVV7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2614464.
GenomeReviews	Gene locus VC_0031 in contig AE003852_GR.
KEGG	vch:VC0031.
PATRIC	20079110. VBIVibCho83274_0030.
TIGR	VC_0031.
Phylogenomic databases
HOGENOM	HBG323037.
OMA	MVLINNQ.
PhylomeDB	Q9KVV7.
ProtClustDB	PRK08978.
Family and domain databases
InterPro	IPR012846. Acetolactate_synth_lsu. IPR012000. Thiamin_PyroP_enz_cen_dom. IPR012001. Thiamin_PyroP_enz_TPP-bd_dom. IPR000399. TPP-bd_CS. IPR011766. TPP_enzyme-bd_C. [Graphical view]
KO	K01652.
PANTHER	PTHR18968:SF13. PTHR18968:SF13. 1 hit.
Pfam	PF02775. TPP_enzyme_C. 1 hit. PF00205. TPP_enzyme_M. 1 hit. PF02776. TPP_enzyme_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00118. Acolac_lg. 1 hit.
PROSITE	PS00187. TPP_ENZYMES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9KVV7_VIBCH

Accession

Primary (citable) accession number: Q9KVV7

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	December 14, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)