Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9KVT8 (PURK_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N5-carboxyaminoimidazole ribonucleotide synthase
Short name=N5-CAIR synthase
EC=6.3.4.18
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide synthetase
Gene names
Name:purK
Ordered Locus Names:VC_0051
OrganismVibrio cholerae
Taxonomic identifier666 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO3- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) By similarity.

Catalytic activity

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3- = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the purK/purT family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377N5-carboxyaminoimidazole ribonucleotide synthase
PRO_0000075015

Regions

Domain97 – 287191ATP-grasp
Nucleotide binding175 – 1784ATP By similarity
Nucleotide binding257 – 2582ATP By similarity

Sites

Binding site931ATP By similarity
Binding site1331ATP By similarity
Binding site1441ATP By similarity
Binding site1831ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KVT8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: D5C1787315454BD3

FASTA37741,014
        10         20         30         40         50         60 
MRVLVLGAGQ LARMMSLAGA PLNIETIAFD VGSENIVHPL TQTVLGHGLE QAIEQVDVIT 

        70         80         90        100        110        120 
AEFEHIPHPI LDLCARSGKL YPSAEAIKAG GDRRLEKALL DRAQVANARY TMIRSRDDLT 

       130        140        150        160        170        180 
SAIAEIGLPM VLKSALGGYD GKGQWRLKEP TQIESVWQEL AQYLAANPEQ AIVAEEFVAF 

       190        200        210        220        230        240 
DREVSLVGAR NLVGDVVVYP LAENVHTQGV LSLSTAIDAP ALQTQAKAMF KAVAEQLNYV 

       250        260        270        280        290        300 
GVLALEFFEV QGQLLVNEIA PRVHNSGHWT QQGAETCQFE NHLRAVCGLP LGSTKLVRET 

       310        320        330        340        350        360 
AMINILGEDQ LPAEVLALEG CHVHWYGKAK RSGRKMGHIN VTADYSGELQ RKLCQLATVL 

       370 
DEKAFPAVHA VAKEIQP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE003852 Genomic DNA. Translation: AAF93229.1.
PIRB82370.
RefSeqNP_229710.1. NC_002505.1.

3D structure databases

ProteinModelPortalQ9KVT8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2614419.
GenomeReviewsGene locus VC_0051 in contig AE003852_GR.
KEGGvch:VC0051.
PATRIC20079150. VBIVibCho83274_0050.
TIGRVC_0051.

Phylogenomic databases

HOGENOMHBG516369.
OMAGRKMGHF.
PhylomeDBQ9KVT8.
ProtClustDBPRK06019.

Family and domain databases

InterProIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR013817. Pre-ATP_grasp.
IPR016185. PreATP-grasp-like.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
Gene3DG3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit.
G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
KOK01589.
PfamPF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR01161. PurK. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePURK_VIBCH
AccessionPrimary (citable) accession number: Q9KVT8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents