Q9KVP7 (UBIA_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-hydroxybenzoate octaprenyltransferase
EC=2.5.1.-

Alternative name(s):
4-HB polyprenyltransferase

Gene names

Name:	ubiA
Ordered Locus Names:	VC_0094

Organism

Vibrio cholerae

Taxonomic identifier

666 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Synthesis of 3-octaprenyl-4-hydroxybenzoate By similarity. HAMAP MF_01635
Catalytic activity	4-hydroxybenzoate + farnesylfarnesylgeraniol = 3-octaprenyl-4-hydroxybenzoate. HAMAP MF_01635
Cofactor	Magnesium By similarity. HAMAP MF_01635
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01635
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01635.
Sequence similarities	Belongs to the UbiA prenyltransferase family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Magnesium
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	prenyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 284	284	4-hydroxybenzoate octaprenyltransferase HAMAP MF_01635		PRO_0000262849
Regions
	Transmembrane	42 – 62	21	Helical; Potential
	Transmembrane	93 – 113	21	Helical; Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Transmembrane	136 – 156	21	Helical; Potential
	Transmembrane	158 – 178	21	Helical; Potential
	Transmembrane	210 – 230	21	Helical; Potential
	Transmembrane	233 – 253	21	Helical; Potential
	Transmembrane	264 – 284	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9KVP7 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 4F9697774C36CAC6	FASTA	284	31,820
	10 20 30 40 50 60 MTAVKARAYW QLMRMDRPIG SLLLLWPTLW ALLLAAQGLP DLRVLVVFVL GVFLMRSAGC 70 80 90 100 110 120 VINDYADRHV DGHVKRTSQR PLPAGLVSAK EALLLFVLLA VSSFLLVLTM NTLTIQLSFI 130 140 150 160 170 180 GILLAFVYPF MKRFTHLPQL VLGLAFSWSI PMAWAAQANT LTPQVWVLFL INALWTIAYD 190 200 210 220 230 240 TQYAMVDRDD DVKIGIKSTA ILFGRWDKRI IGLLQLATLS LLVALGQGLA LGTSYYWGLL 250 260 270 280 IAAGLFAYQQ HLIRYRERMP CFQAFLNNNY VGMAITAGIL LSVW

References

[1]

"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae." Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S. , Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M. Nature 406:477-483(2000) [PubMed: 10952301] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39315 / El Tor Inaba N16961 / Serotype O1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE003852 Genomic DNA. Translation: AAF93272.1.
PIR	C82365.
RefSeq	NP_229753.1. NC_002505.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2615771.
GenomeReviews	Gene locus VC_0094 in contig AE003852_GR.
KEGG	vch:VC0094.
PATRIC	20079244. VBIVibCho83274_0091.
TIGR	VC_0094.
Phylogenomic databases
HOGENOM	HBG324383.
OMA	VLIPWAA.
PhylomeDB	Q9KVP7.
ProtClustDB	PRK12848.
Family and domain databases
HAMAP	MF_01635. UbiA. [Tree]
InterPro	IPR006370. HB_polyprenyl-transferase. IPR000537. UbiA_prenyltransferase. [Graphical view]
KO	K03179.
Pfam	PF01040. UbiA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01474. UbiA_proteo. 1 hit.
PROSITE	PS00943. UBIA. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIA_VIBCH

Accession

Primary (citable) accession number: Q9KVP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program