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Q9KVM1 (HEM3_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Porphobilinogen deaminase
Short name=PBG
EC=2.5.1.61
Alternative name(s):
Hydroxymethylbilane synthase
Short name=HMBS
Pre-uroporphyrinogen synthase
Gene names
Name:hemC
Ordered Locus Names:VC_0120
OrganismVibrio cholerae
Taxonomic identifier666 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. HAMAP MF_00260

Catalytic activity

4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3. HAMAP MF_00260

Cofactor

Binds 1 dipyrromethane group covalently By similarity. HAMAP MF_00260

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4. HAMAP MF_00260

Subunit structure

Monomer By similarity. HAMAP MF_00260

Miscellaneous

The porphobilinogen subunits are added to the dipyrromethan group. HAMAP MF_00260

Sequence similarities

Belongs to the HMBS family.

Sequence caution

The sequence AAF93298.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Porphobilinogen deaminase HAMAP MF_00260
PRO_0000143005

Amino acid modifications

Modified residue2421S-(dipyrrolylmethanemethyl)cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KVM1 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: 1EB05C0791FC62AD

FASTA31133,849
        10         20         30         40         50         60 
MTETPIRIAT RQSPLALWQA NYVKDALMAA HPGLQVELVT MVTRGDVILD TPLAKVGGKG 

        70         80         90        100        110        120 
LFVKELEIAM LEGRADLAVH SMKDVPVDFP DGLGLVTICE REDPRDAFVS NTYAKIEDLP 

       130        140        150        160        170        180 
SGAIVGTCSL RRQCQLKAAR PDLVIKELRG NVGTRLSKLD AGEYDAIILA AAGLKRLELE 

       190        200        210        220        230        240 
SRIRSFIEPE QSLPAVGQGA VGIECRVNDQ RVRALLAPLN HADTADRVRC ERAMNLTLQG 

       250        260        270        280        290        300 
GCQVPIGSYA LLEGDTIWLR ALVGEPDGSQ IVRGEIRGPR TQAEQLGITL AEQLLSQGAK 

       310 
EILERLYCDH E

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE003852 Genomic DNA. Translation: AAF93298.1. Different initiation.
PIRF82362.
RefSeqNP_229779.1. NC_002505.1.

3D structure databases

ProteinModelPortalQ9KVM1.
SMRQ9KVM1. Positions 6-307.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2614463.
GenomeReviewsGene locus VC_0120 in contig AE003852_GR.
KEGGvch:VC0120.
PATRIC20079284. VBIVibCho83274_0111.
TIGRVC_0120.

Phylogenomic databases

HOGENOMHBG624842.
OMAFKDVRGN.
PhylomeDBQ9KVM1.
ProtClustDBPRK00072.

Family and domain databases

HAMAPMF_00260. Porphobil_deam.
[Tree]
InterProIPR000860. 4pyrrol_synth_OHMeBilane_synth.
IPR022419. Porphobilin_deaminase_cofac_BS.
IPR022417. Porphobilin_deaminase_N.
IPR022418. Porphobilinogen_deaminase_C.
[Graphical view]
Gene3DG3DSA:3.30.160.40. Porphobil_deam. 1 hit.
KOK01749.
PANTHERPTHR11557. Porphobil_deam. 1 hit.
PfamPF01379. Porphobil_deam. 1 hit.
PF03900. Porphobil_deamC. 1 hit.
[Graphical view]
PIRSFPIRSF001438. 4pyrrol_synth_OHMeBilane_synth. 1 hit.
PRINTSPR00151. PORPHBDMNASE.
SUPFAMSSF54782. Porphobil_deam. 1 hit.
TIGRFAMsTIGR00212. HemC. 1 hit.
PROSITEPS00533. PORPHOBILINOGEN_DEAM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEM3_VIBCH
AccessionPrimary (citable) accession number: Q9KVM1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: January 25, 2012
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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