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Q9KVD2

- SLMA_VIBCH

UniProt

Q9KVD2 - SLMA_VIBCH

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Protein
Nucleoid occlusion factor SlmA
Gene
slmA, VC_0214
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi31 – 5020H-T-H motif By similarity
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: UniProtKB-HAMAP
  2. sequence-specific DNA binding transcription factor activity Source: TIGR
Complete GO annotation...

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. negative regulation of barrier septum assembly Source: InterPro
  4. regulation of transcription, DNA-templated Source: TIGR
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoid occlusion factor SlmA
Gene namesi
Name:slmA
Ordered Locus Names:VC_0214
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

Subcellular locationi

Cytoplasmnucleoid By similarity UniRule annotation

GO - Cellular componenti

  1. bacterial nucleoid Source: UniProtKB-HAMAP
  2. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Nucleoid occlusion factor SlmAUniRule annotation
PRO_0000198983Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity. Interacts with FtsZ By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243277.VC0214.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 2113
Helixi25 – 273
Helixi32 – 398
Helixi43 – 497
Helixi53 – 7826
Helixi82 – 9918
Helixi101 – 1088
Helixi112 – 1154
Helixi117 – 14529
Helixi153 – 17321
Turni174 – 1763
Turni180 – 1834
Helixi184 – 1929
Turni193 – 1953

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GCTX-ray2.45A/B/C/D1-196[»]
4GFKX-ray1.95A/B1-196[»]
ProteinModelPortaliQ9KVD2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 6862HTH tetR-type
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili110 – 13930 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG1309.
KOiK05501.
OMAiEKDTSAR.
OrthoDBiEOG6G7R3C.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
HAMAPiMF_01839. NO_factor_SlmA.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR023769. NO_SlmA.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KVD2-1 [UniParc]FASTAAdd to Basket

« Hide

MAGNKKINRR EEILQALAEM LESNEGASRI TTAKLAKQVG VSEAALYRHF    50
PSKARMFEGL IEFIEESLMS RINRIFDEEK DTLNRIRLVM QLLLAFAERN 100
PGLTRILSGH ALMFENERLR DRINQLFERI ETSLRQILRE RKLREGKSFP 150
VDENILAAQL LGQVEGSLNR FVRSDFKYLP TANFDEYWAL LSAQIK 196
Length:196
Mass (Da):22,743
Last modified:August 16, 2005 - v2
Checksum:iD3546115CEC238BD
GO

Sequence cautioni

The sequence AAF93390.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF93390.1. Different initiation.
PIRiH82350.
RefSeqiNP_229871.2. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF93390; AAF93390; VC_0214.
GeneIDi2614568.
KEGGivch:VC0214.
PATRICi20079472. VBIVibCho83274_0195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF93390.1 . Different initiation.
PIRi H82350.
RefSeqi NP_229871.2. NC_002505.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GCT X-ray 2.45 A/B/C/D 1-196 [» ]
4GFK X-ray 1.95 A/B 1-196 [» ]
ProteinModelPortali Q9KVD2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243277.VC0214.

Protocols and materials databases

DNASUi 2614568.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF93390 ; AAF93390 ; VC_0214 .
GeneIDi 2614568.
KEGGi vch:VC0214.
PATRICi 20079472. VBIVibCho83274_0195.

Phylogenomic databases

eggNOGi COG1309.
KOi K05501.
OMAi EKDTSAR.
OrthoDBi EOG6G7R3C.

Family and domain databases

Gene3Di 1.10.357.10. 1 hit.
HAMAPi MF_01839. NO_factor_SlmA.
InterProi IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR023769. NO_SlmA.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view ]
Pfami PF00440. TetR_N. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEi PS50977. HTH_TETR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiSLMA_VIBCH
AccessioniPrimary (citable) accession number: Q9KVD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: May 14, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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