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Q9KVD2 (SLMA_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Nucleoid occlusion factor SlmA
Gene names
Name:slmA
Ordered Locus Names:VC_0214
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions By similarity. HAMAP-Rule MF_01839

Subunit structure

Homodimer By similarity. Interacts with FtsZ By similarity. HAMAP-Rule MF_01839

Subcellular location

Cytoplasmnucleoid By similarity HAMAP-Rule MF_01839.

Sequence similarities

Belongs to the nucleoid occlusion factor SlmA family.

Contains 1 HTH tetR-type DNA-binding domain.

Sequence caution

The sequence AAF93390.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 196196Nucleoid occlusion factor SlmA HAMAP-Rule MF_01839
PRO_0000198983

Regions

Domain7 – 6862HTH tetR-type
DNA binding31 – 5020H-T-H motif By similarity
Coiled coil110 – 13930 Potential

Secondary structure

.......................... 196
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9KVD2 [UniParc].

Last modified August 16, 2005. Version 2.
Checksum: D3546115CEC238BD

FASTA19622,743
        10         20         30         40         50         60 
MAGNKKINRR EEILQALAEM LESNEGASRI TTAKLAKQVG VSEAALYRHF PSKARMFEGL 

        70         80         90        100        110        120 
IEFIEESLMS RINRIFDEEK DTLNRIRLVM QLLLAFAERN PGLTRILSGH ALMFENERLR 

       130        140        150        160        170        180 
DRINQLFERI ETSLRQILRE RKLREGKSFP VDENILAAQL LGQVEGSLNR FVRSDFKYLP 

       190 
TANFDEYWAL LSAQIK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF93390.1. Different initiation.
PIRH82350.
RefSeqNP_229871.2. NC_002505.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4GCTX-ray2.45A/B/C/D1-196[»]
4GFKX-ray1.95A/B1-196[»]
ProteinModelPortalQ9KVD2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC0214.

Protocols and materials databases

DNASU2614568.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF93390; AAF93390; VC_0214.
GeneID2614568.
KEGGvch:VC0214.
PATRIC20079472. VBIVibCho83274_0195.

Phylogenomic databases

eggNOGCOG1309.
KOK05501.
OMAEKDTSAR.
OrthoDBEOG6G7R3C.

Family and domain databases

Gene3D1.10.357.10. 1 hit.
HAMAPMF_01839. NO_factor_SlmA.
InterProIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR023769. NO_SlmA.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSLMA_VIBCH
AccessionPrimary (citable) accession number: Q9KVD2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: May 14, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references