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Q9KVD2

- SLMA_VIBCH

UniProt

Q9KVD2 - SLMA_VIBCH

Protein

Nucleoid occlusion factor SlmA

Gene

slmA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (16 Aug 2005)
      Previous versions | rss
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    Functioni

    Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi31 – 5020H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: UniProtKB-HAMAP
    2. sequence-specific DNA binding transcription factor activity Source: TIGR

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. negative regulation of barrier septum assembly Source: InterPro
    4. regulation of transcription, DNA-templated Source: TIGR

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoid occlusion factor SlmAUniRule annotation
    Gene namesi
    Name:slmAUniRule annotation
    Ordered Locus Names:VC_0214
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    Subcellular locationi

    Cytoplasmnucleoid UniRule annotation

    GO - Cellular componenti

    1. bacterial nucleoid Source: UniProtKB-HAMAP
    2. cytoplasm Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 196196Nucleoid occlusion factor SlmAPRO_0000198983Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer. Interacts with FtsZ.UniRule annotation

    Protein-protein interaction databases

    STRINGi243277.VC0214.

    Structurei

    Secondary structure

    1
    196
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi9 – 2113
    Helixi25 – 273
    Helixi32 – 398
    Helixi43 – 497
    Helixi53 – 7826
    Helixi82 – 9918
    Helixi101 – 1088
    Helixi112 – 1154
    Helixi117 – 14529
    Helixi153 – 17321
    Turni174 – 1763
    Turni180 – 1834
    Helixi184 – 1929
    Turni193 – 1953

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GCTX-ray2.45A/B/C/D1-196[»]
    4GFKX-ray1.95A/B1-196[»]
    ProteinModelPortaliQ9KVD2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 6862HTH tetR-typeUniRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili110 – 13930UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the nucleoid occlusion factor SlmA family.UniRule annotation
    Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG1309.
    KOiK05501.
    OMAiEKDTSAR.
    OrthoDBiEOG6G7R3C.

    Family and domain databases

    Gene3Di1.10.357.10. 1 hit.
    HAMAPiMF_01839. NO_factor_SlmA.
    InterProiIPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR023769. NO_SlmA.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view]
    PfamiPF00440. TetR_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEiPS50977. HTH_TETR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KVD2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGNKKINRR EEILQALAEM LESNEGASRI TTAKLAKQVG VSEAALYRHF    50
    PSKARMFEGL IEFIEESLMS RINRIFDEEK DTLNRIRLVM QLLLAFAERN 100
    PGLTRILSGH ALMFENERLR DRINQLFERI ETSLRQILRE RKLREGKSFP 150
    VDENILAAQL LGQVEGSLNR FVRSDFKYLP TANFDEYWAL LSAQIK 196
    Length:196
    Mass (Da):22,743
    Last modified:August 16, 2005 - v2
    Checksum:iD3546115CEC238BD
    GO

    Sequence cautioni

    The sequence AAF93390.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF93390.1. Different initiation.
    PIRiH82350.
    RefSeqiNP_229871.2. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF93390; AAF93390; VC_0214.
    GeneIDi2614568.
    KEGGivch:VC0214.
    PATRICi20079472. VBIVibCho83274_0195.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF93390.1 . Different initiation.
    PIRi H82350.
    RefSeqi NP_229871.2. NC_002505.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GCT X-ray 2.45 A/B/C/D 1-196 [» ]
    4GFK X-ray 1.95 A/B 1-196 [» ]
    ProteinModelPortali Q9KVD2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC0214.

    Protocols and materials databases

    DNASUi 2614568.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF93390 ; AAF93390 ; VC_0214 .
    GeneIDi 2614568.
    KEGGi vch:VC0214.
    PATRICi 20079472. VBIVibCho83274_0195.

    Phylogenomic databases

    eggNOGi COG1309.
    KOi K05501.
    OMAi EKDTSAR.
    OrthoDBi EOG6G7R3C.

    Family and domain databases

    Gene3Di 1.10.357.10. 1 hit.
    HAMAPi MF_01839. NO_factor_SlmA.
    InterProi IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR023769. NO_SlmA.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    [Graphical view ]
    Pfami PF00440. TetR_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEi PS50977. HTH_TETR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiSLMA_VIBCH
    AccessioniPrimary (citable) accession number: Q9KVD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: August 16, 2005
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3