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Protein

Nucleoid occlusion factor SlmA

Gene

slmA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi31 – 5020H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

  • sequence-specific DNA binding Source: UniProtKB-HAMAP
  • sequence-specific DNA binding transcription factor activity Source: TIGR

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoid occlusion factor SlmAUniRule annotation
Gene namesi
Name:slmAUniRule annotation
Ordered Locus Names:VC_0214
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasmnucleoid UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Nucleoid occlusion factor SlmAPRO_0000198983Add
BLAST

Interactioni

Subunit structurei

Homodimer. Interacts with FtsZ.UniRule annotation

Protein-protein interaction databases

STRINGi243277.VC0214.

Structurei

Secondary structure

1
196
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 2113Combined sources
Helixi25 – 273Combined sources
Helixi32 – 398Combined sources
Helixi43 – 497Combined sources
Helixi53 – 7826Combined sources
Helixi82 – 9918Combined sources
Helixi101 – 1088Combined sources
Helixi112 – 1154Combined sources
Helixi117 – 14529Combined sources
Helixi153 – 17321Combined sources
Turni174 – 1763Combined sources
Turni180 – 1834Combined sources
Helixi184 – 1929Combined sources
Turni193 – 1953Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GCTX-ray2.45A/B/C/D1-196[»]
4GFKX-ray1.95A/B1-196[»]
ProteinModelPortaliQ9KVD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 6862HTH tetR-typeUniRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili110 – 13930UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the nucleoid occlusion factor SlmA family.UniRule annotation
Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG1309.
KOiK05501.
OMAiEKDTSAR.
OrthoDBiEOG6G7R3C.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
HAMAPiMF_01839. NO_factor_SlmA.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR023769. NO_SlmA.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KVD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNKKINRR EEILQALAEM LESNEGASRI TTAKLAKQVG VSEAALYRHF
60 70 80 90 100
PSKARMFEGL IEFIEESLMS RINRIFDEEK DTLNRIRLVM QLLLAFAERN
110 120 130 140 150
PGLTRILSGH ALMFENERLR DRINQLFERI ETSLRQILRE RKLREGKSFP
160 170 180 190
VDENILAAQL LGQVEGSLNR FVRSDFKYLP TANFDEYWAL LSAQIK
Length:196
Mass (Da):22,743
Last modified:August 16, 2005 - v2
Checksum:iD3546115CEC238BD
GO

Sequence cautioni

The sequence AAF93390.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF93390.1. Different initiation.
PIRiH82350.
RefSeqiNP_229871.2. NC_002505.1.
WP_000918350.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF93390; AAF93390; VC_0214.
GeneIDi2614568.
KEGGivch:VC0214.
PATRICi20079472. VBIVibCho83274_0195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF93390.1. Different initiation.
PIRiH82350.
RefSeqiNP_229871.2. NC_002505.1.
WP_000918350.1. NC_002505.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GCTX-ray2.45A/B/C/D1-196[»]
4GFKX-ray1.95A/B1-196[»]
ProteinModelPortaliQ9KVD2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC0214.

Protocols and materials databases

DNASUi2614568.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF93390; AAF93390; VC_0214.
GeneIDi2614568.
KEGGivch:VC0214.
PATRICi20079472. VBIVibCho83274_0195.

Phylogenomic databases

eggNOGiCOG1309.
KOiK05501.
OMAiEKDTSAR.
OrthoDBiEOG6G7R3C.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
HAMAPiMF_01839. NO_factor_SlmA.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR023769. NO_SlmA.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiSLMA_VIBCH
AccessioniPrimary (citable) accession number: Q9KVD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: May 27, 2015
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.