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Q9KV53

- GPPA_VIBCH

UniProt

Q9KV53 - GPPA_VIBCH

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular response to starvation Source: TIGR
  2. guanosine pentaphosphate catabolic process Source: InterPro
  3. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciVCHO:VC0304-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:VC_0304
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000194292Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC0304.

Structurei

3D structure databases

ProteinModelPortaliQ9KV53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
KOiK01524.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KV53-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQAVSSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE
60 70 80 90 100
HNALSLDAMQ RGWDCLSLFA ERLQDIPAEN IRIVGTATLR TATNAGEFIA
110 120 130 140 150
KANQILGHPI DVISGEEEAA TIYKGVAHTS GGLGRRLVVD IGGASTELII
160 170 180 190 200
GEGFEAKALT SLKMGCVTWL ERHFKDRQLT ATNFNNAILA AKQMLDPILT
210 220 230 240 250
QYTELGWNVC VGASGTVQAL QEIMLAQGMD EVITLTKLKR LQKQAMLADH
260 270 280 290 300
LEELDIEGLT LERALVFPSG LSILIAIFES LNIEAMTLAG GALREGLVYE
310 320 330 340 350
MVQDLRQEDI RARTIRCVQT RYQIDSAYGD QVATLASKLL AQCGGEAWIN
360 370 380 390 400
EPQAEMLLRT AAKLHEIGLT IDFKKGGEHS AYLLQHLDLP GYTRAQKHYL
410 420 430 440 450
GEIVRRYREQ LTSLPEQYAL SGTSGKRVLR LLRLAVLLSH RRSPALEPMV
460 470 480 490
ELSAQEDKLT LTLDGEWLAK NPLTRTELEL EANRQTDIGW PLSIECH
Length:497
Mass (Da):54,826
Last modified:October 1, 2000 - v1
Checksum:iBB0BD17FF3B3A331
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF93478.1.
PIRiB82340.
RefSeqiNP_229959.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF93478; AAF93478; VC_0304.
GeneIDi2614974.
KEGGivch:VC0304.
PATRICi20079653. VBIVibCho83274_0285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF93478.1 .
PIRi B82340.
RefSeqi NP_229959.1. NC_002505.1.

3D structure databases

ProteinModelPortali Q9KV53.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC0304.

Protocols and materials databases

DNASUi 2614974.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF93478 ; AAF93478 ; VC_0304 .
GeneIDi 2614974.
KEGGi vch:VC0304.
PATRICi 20079653. VBIVibCho83274_0285.

Phylogenomic databases

eggNOGi COG0248.
KOi K01524.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci VCHO:VC0304-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiGPPA_VIBCH
AccessioniPrimary (citable) accession number: Q9KV53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3