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Q9KV53

- GPPA_VIBCH

UniProt

Q9KV53 - GPPA_VIBCH

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular response to starvation Source: TIGR
    2. guanosine pentaphosphate catabolic process Source: InterPro
    3. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciVCHO:VC0304-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:VC_0304
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_0000194292Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VC0304.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KV53.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    KOiK01524.
    OMAiGLHIEYK.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KV53-1 [UniParc]FASTAAdd to Basket

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    MSQAVSSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE    50
    HNALSLDAMQ RGWDCLSLFA ERLQDIPAEN IRIVGTATLR TATNAGEFIA 100
    KANQILGHPI DVISGEEEAA TIYKGVAHTS GGLGRRLVVD IGGASTELII 150
    GEGFEAKALT SLKMGCVTWL ERHFKDRQLT ATNFNNAILA AKQMLDPILT 200
    QYTELGWNVC VGASGTVQAL QEIMLAQGMD EVITLTKLKR LQKQAMLADH 250
    LEELDIEGLT LERALVFPSG LSILIAIFES LNIEAMTLAG GALREGLVYE 300
    MVQDLRQEDI RARTIRCVQT RYQIDSAYGD QVATLASKLL AQCGGEAWIN 350
    EPQAEMLLRT AAKLHEIGLT IDFKKGGEHS AYLLQHLDLP GYTRAQKHYL 400
    GEIVRRYREQ LTSLPEQYAL SGTSGKRVLR LLRLAVLLSH RRSPALEPMV 450
    ELSAQEDKLT LTLDGEWLAK NPLTRTELEL EANRQTDIGW PLSIECH 497
    Length:497
    Mass (Da):54,826
    Last modified:October 1, 2000 - v1
    Checksum:iBB0BD17FF3B3A331
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF93478.1.
    PIRiB82340.
    RefSeqiNP_229959.1. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF93478; AAF93478; VC_0304.
    GeneIDi2614974.
    KEGGivch:VC0304.
    PATRICi20079653. VBIVibCho83274_0285.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF93478.1 .
    PIRi B82340.
    RefSeqi NP_229959.1. NC_002505.1.

    3D structure databases

    ProteinModelPortali Q9KV53.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC0304.

    Protocols and materials databases

    DNASUi 2614974.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF93478 ; AAF93478 ; VC_0304 .
    GeneIDi 2614974.
    KEGGi vch:VC0304.
    PATRICi 20079653. VBIVibCho83274_0285.

    Phylogenomic databases

    eggNOGi COG0248.
    KOi K01524.
    OMAi GLHIEYK.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci VCHO:VC0304-MONOMER.

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiGPPA_VIBCH
    AccessioniPrimary (citable) accession number: Q9KV53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3