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Q9KV53 (GPPA_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:VC_0304
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_0000194292

Sequences

Sequence LengthMass (Da)Tools
Q9KV53 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: BB0BD17FF3B3A331

FASTA49754,826
        10         20         30         40         50         60 
MSQAVSSPLY AAIDLGSNSF HMLVVRHIDG SVQTMAKIKR KVRLAAGLDE HNALSLDAMQ 

        70         80         90        100        110        120 
RGWDCLSLFA ERLQDIPAEN IRIVGTATLR TATNAGEFIA KANQILGHPI DVISGEEEAA 

       130        140        150        160        170        180 
TIYKGVAHTS GGLGRRLVVD IGGASTELII GEGFEAKALT SLKMGCVTWL ERHFKDRQLT 

       190        200        210        220        230        240 
ATNFNNAILA AKQMLDPILT QYTELGWNVC VGASGTVQAL QEIMLAQGMD EVITLTKLKR 

       250        260        270        280        290        300 
LQKQAMLADH LEELDIEGLT LERALVFPSG LSILIAIFES LNIEAMTLAG GALREGLVYE 

       310        320        330        340        350        360 
MVQDLRQEDI RARTIRCVQT RYQIDSAYGD QVATLASKLL AQCGGEAWIN EPQAEMLLRT 

       370        380        390        400        410        420 
AAKLHEIGLT IDFKKGGEHS AYLLQHLDLP GYTRAQKHYL GEIVRRYREQ LTSLPEQYAL 

       430        440        450        460        470        480 
SGTSGKRVLR LLRLAVLLSH RRSPALEPMV ELSAQEDKLT LTLDGEWLAK NPLTRTELEL 

       490 
EANRQTDIGW PLSIECH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF93478.1.
PIRB82340.
RefSeqNP_229959.1. NC_002505.1.

3D structure databases

ProteinModelPortalQ9KV53.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC0304.

Protocols and materials databases

DNASU2614974.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF93478; AAF93478; VC_0304.
GeneID2614974.
KEGGvch:VC0304.
PATRIC20079653. VBIVibCho83274_0285.

Phylogenomic databases

eggNOGCOG0248.
KOK01524.
OMAGLHIEYK.
OrthoDBEOG6M6JN6.

Enzyme and pathway databases

BioCycVCHO:VC0304-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_VIBCH
AccessionPrimary (citable) accession number: Q9KV53
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways