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Q9KV30

- RPOB_VIBCH

UniProt

Q9KV30 - RPOB_VIBCH

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Protein
DNA-directed RNA polymerase subunit beta
Gene
rpoB, VC_0328
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates By similarity.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. DNA-directed RNA polymerase activity Source: TIGR
  3. ribonucleoside binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit beta (EC:2.7.7.6)
Short name:
RNAP subunit beta
Alternative name(s):
RNA polymerase subunit beta
Transcriptase subunit beta
Gene namesi
Name:rpoB
Ordered Locus Names:VC_0328
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13411341DNA-directed RNA polymerase subunit betaUniRule annotation
PRO_0000047992Add
BLAST

Proteomic databases

PRIDEiQ9KV30.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity.

Protein-protein interaction databases

STRINGi243277.VC0328.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi228 – 24114
Helixi243 – 2464
Beta strandi255 – 2573
Beta strandi260 – 2634
Helixi271 – 2799
Beta strandi284 – 2874
Helixi289 – 2935
Beta strandi308 – 31710
Helixi319 – 3279

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E7HX-ray1.70A/B228-329[»]
ProteinModelPortaliQ9KV30.

Miscellaneous databases

EvolutionaryTraceiQ9KV30.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0085.
KOiK03043.
OMAiICPANME.
OrthoDBiEOG6M9DS6.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 2 hits.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR010243. DNA-dir_RNA_pol_bsu.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KV30-1 [UniParc]FASTAAdd to Basket

« Hide

MVYSYTEKKR IRKDFGTRPQ VLDIPYLLSI QLDSFEKFIE QDPEGQYGLE     50
AAFRSVFPIQ SYNGNSELQY VSYRLGEPVF DVKECQIRGV TYSKPLRVKL 100
RLVIFDKDAP AGTVKDIKEQ EVYMGEIPLM TENGTFVING TERVIVSQLH 150
RSPGVFFDSD KGKTHSSGKV LYNARIIPYR GSWLDFEFDP KDNLYVRIDR 200
RRKLPASIIL RALGKTSAEI LDIFFEKVNF EVKDQTLMME LVPERLRGET 250
ATFDIEADGK VYVEKGRRVT ARHIRQLEKD GVNFIEVPVE YIVGKVSAKD 300
YVNEATGELI ITANQEISLE ALANLSQAGY KKLEVLFTND LDHGPFMSET 350
LRVDSTTDRI SALVEIYRMM RPGEPPTKEA AESLFESLFF SAERYDLSTV 400
GRMKFNSSIG REDAEEQGTL DEVDIIEVMK KLISIRNGKG EVDDIDHLGN 450
RRIRSVGEMA ENQFRVGLVR VERAVKERLS LGDLDNVMPQ DLINAKPISA 500
AVKEFFGSSQ LSQFMDQNNP LSEVTHKRRI SALGPGGLTR ERAGFEVRDV 550
HVTHYGRLCP IETPEGPNIG LINSLSAFAR CNEYGFLETP YRRVVNGVVT 600
DEVDYLSAIE EGQFVIAQAN AKLTEEGGFA DELVTARQKG ESGLHPREHV 650
DYMDVATNQV VSIAASLIPF LEHDDANRAL MGANMQRQAV PTLRSEKPLV 700
GTGIERNVAV DSGVTAVAKR GGVIQSVDAS RIVVKVNEEE LIPGEAGIDI 750
YNLTKYTRSN QNTCINQRPC VMPGEPVARG DVLADGPSTD LGELALGQNM 800
RIAFMPWNGY NFEDSILVSE RVVQDDRFTT IHIQELSCVA RDTKLGAEEI 850
TADIPNVGEA ALSKLDESGI VYIGAEVKGG DILVGKVTPK GETQLTPEEK 900
LLRAIFGEKA SDVKDTSLRV PNSVAGTVID VQVFTRDGVE KDKRALEIEQ 950
MQLKEAKKDL TEEFQILEGG LLARVRSVLL AGGYTEAKLG SIERKKWLEQ 1000
TLENEELQNQ LEQLAEQYDE LKADFDKKFE AKRRKITQGD DLAPGVLKIV 1050
KVYLAVKRRI QPGDKMAGRH GNKGVISKIN PVEDMPYDEN GQPVDIVLNP 1100
LGVPSRMNIG QILEVHLGLA AKGIGDKINQ MIKEQQELAK LREFLQKVYD 1150
LGDTRQRVDI SELSDEDVRT LAHNLRAGLP VATPVFDGAP ESSIKAMLEL 1200
ADLPASGQLT LFDGRTGDAF ERPVTVGYMY MLKLNHLVDD KMHARSTGSY 1250
SLVTQQPLGG KAQFGGQRFG EMEVWALEAY GAAYTLQEML TVKSDDVNGR 1300
TKMYKNIVDG NHAMEPGMPE SFNVLLKEIR SLGINIELED E 1341
Length:1,341
Mass (Da):149,455
Last modified:January 16, 2004 - v2
Checksum:i9C6C824A923295A9
GO

Sequence cautioni

The sequence AAF93501.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF93501.1. Different initiation.
PIRiF82336.
RefSeqiNP_229982.2. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF93501; AAF93501; VC_0328.
GeneIDi2615094.
KEGGivch:VC0328.
PATRICi20079713. VBIVibCho83274_0305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF93501.1 . Different initiation.
PIRi F82336.
RefSeqi NP_229982.2. NC_002505.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3E7H X-ray 1.70 A/B 228-329 [» ]
ProteinModelPortali Q9KV30.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243277.VC0328.

Proteomic databases

PRIDEi Q9KV30.

Protocols and materials databases

DNASUi 2615094.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF93501 ; AAF93501 ; VC_0328 .
GeneIDi 2615094.
KEGGi vch:VC0328.
PATRICi 20079713. VBIVibCho83274_0305.

Phylogenomic databases

eggNOGi COG0085.
KOi K03043.
OMAi ICPANME.
OrthoDBi EOG6M9DS6.

Miscellaneous databases

EvolutionaryTracei Q9KV30.

Family and domain databases

Gene3Di 2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 2 hits.
3.90.1110.10. 2 hits.
HAMAPi MF_01321. RNApol_bact_RpoB.
InterProi IPR010243. DNA-dir_RNA_pol_bsu.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view ]
PANTHERi PTHR20856. PTHR20856. 1 hit.
Pfami PF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02013. rpoB. 1 hit.
PROSITEi PS01166. RNA_POL_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiRPOB_VIBCH
AccessioniPrimary (citable) accession number: Q9KV30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: January 16, 2004
Last modified: June 11, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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