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Q9KUY4 (G6PI_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:VC_0374
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from sequence or structural similarity Ref.1. Source: TIGR

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from sequence or structural similarity Ref.1. Source: TIGR

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180762

Sites

Active site3561Proton donor By similarity
Active site3871 By similarity
Active site5151 By similarity

Secondary structure

................................................................................................ 550
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9KUY4 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 5E38B0421C3A1B16

FASTA55060,691
        10         20         30         40         50         60 
MLKNINPTQT QAWKALTAHF ESAQDMDLKA LFAQDSERFA KYSARFGQDI LVDYSKNLVN 

        70         80         90        100        110        120 
AETMQHLFAL AKETDLQSAI TAMFKGEAIN QTEDRAVLHT ALRNRSNSPV LVNGEDVMPA 

       130        140        150        160        170        180 
VNAVLAKMKA FSERVIGGEW KGFTGKAITD VVNIGIGGSD LGPYMVTEAL VPYKNHLTMH 

       190        200        210        220        230        240 
FVSNVDGTHM AETLKNVDPE TTLFLVASKT FTTQETMTNA HTARDWFLKA AGDEAHVAKH 

       250        260        270        280        290        300 
FAALSTNGKA VAEFGIDTDN MFEFWDWVGG RYSLWSAIGL SIILSIGYDN FVELLAGAHE 

       310        320        330        340        350        360 
MDQHFVNTPF ESNIPVILAL IGIWYNNFHG AESEAILPYD QYLHRFAAYF QQGNMESNGK 

       370        380        390        400        410        420 
YVDRNGNPVT YQTGPIIWGE PGTNGQHAFY QLIHQGTKLI PCDFIAPAVS HNLVGDHHQK 

       430        440        450        460        470        480 
LMSNFFAQTE ALAFGKSAQA VQAELEKAGK SAAEIAALVP FKVFEGNRPT NSILVKQITP 

       490        500        510        520        530        540 
RTLGNLIAMY EHKIFVQGVI WNIFSFDQWG VELGKQLANQ ILPELADSAA VTSHDSSTNG 

       550 
LINAFKAFRA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF93547.1.
PIRB82330.
RefSeqNP_230028.1. NC_002505.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3HJBX-ray1.50A/B/C/D1-550[»]
ProteinModelPortalQ9KUY4.
SMRQ9KUY4. Positions 8-549.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC0374.

Protocols and materials databases

DNASU2615017.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF93547; AAF93547; VC_0374.
GeneID2615017.
KEGGvch:VC0374.
PATRIC20079819. VBIVibCho83274_0350.

Phylogenomic databases

eggNOGCOG0166.
KOK01810.
OMANCHFVAN.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycVCHO:VC0374-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9KUY4.

Entry information

Entry nameG6PI_VIBCH
AccessionPrimary (citable) accession number: Q9KUY4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways