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Q9KUY4

- G6PI_VIBCH

UniProt

Q9KUY4 - G6PI_VIBCH

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei356 – 3561Proton donorBy similarity
    Active sitei387 – 3871By similarity
    Active sitei515 – 5151By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: TIGR

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: TIGR

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    BioCyciVCHO:VC0374-MONOMER.
    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Name:pgi
    Ordered Locus Names:VC_0374
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 550550Glucose-6-phosphate isomerasePRO_0000180762Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VC0374.

    Structurei

    Secondary structure

    1
    550
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 93
    Helixi11 – 2313
    Helixi28 – 336
    Helixi38 – 414
    Beta strandi43 – 464
    Turni47 – 493
    Beta strandi50 – 534
    Beta strandi56 – 583
    Helixi61 – 7313
    Helixi76 – 8510
    Turni91 – 944
    Helixi99 – 1024
    Beta strandi115 – 1173
    Helixi118 – 13720
    Beta strandi150 – 1545
    Helixi157 – 1593
    Helixi161 – 1699
    Helixi171 – 1733
    Beta strandi178 – 1825
    Helixi187 – 1948
    Helixi199 – 2013
    Beta strandi202 – 2076
    Beta strandi209 – 2113
    Helixi214 – 23118
    Helixi234 – 2396
    Beta strandi241 – 2466
    Helixi248 – 2547
    Helixi258 – 2603
    Helixi270 – 2723
    Turni274 – 2763
    Helixi277 – 2793
    Helixi280 – 2867
    Helixi288 – 30720
    Helixi310 – 3123
    Helixi314 – 32714
    Beta strandi333 – 3397
    Helixi341 – 3433
    Helixi346 – 35813
    Beta strandi376 – 3783
    Turni382 – 3854
    Helixi386 – 39510
    Beta strandi396 – 3983
    Beta strandi402 – 4098
    Helixi417 – 43418
    Helixi438 – 44710
    Helixi452 – 46211
    Beta strandi470 – 4767
    Helixi480 – 50021
    Helixi509 – 5113
    Helixi512 – 52110
    Helixi522 – 5254
    Beta strandi526 – 5283
    Helixi536 – 54914

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3HJBX-ray1.50A/B/C/D1-550[»]
    ProteinModelPortaliQ9KUY4.
    SMRiQ9KUY4. Positions 8-549.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9KUY4.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    KOiK01810.
    OMAiNCHFVAN.
    OrthoDBiEOG64R61J.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KUY4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKNINPTQT QAWKALTAHF ESAQDMDLKA LFAQDSERFA KYSARFGQDI    50
    LVDYSKNLVN AETMQHLFAL AKETDLQSAI TAMFKGEAIN QTEDRAVLHT 100
    ALRNRSNSPV LVNGEDVMPA VNAVLAKMKA FSERVIGGEW KGFTGKAITD 150
    VVNIGIGGSD LGPYMVTEAL VPYKNHLTMH FVSNVDGTHM AETLKNVDPE 200
    TTLFLVASKT FTTQETMTNA HTARDWFLKA AGDEAHVAKH FAALSTNGKA 250
    VAEFGIDTDN MFEFWDWVGG RYSLWSAIGL SIILSIGYDN FVELLAGAHE 300
    MDQHFVNTPF ESNIPVILAL IGIWYNNFHG AESEAILPYD QYLHRFAAYF 350
    QQGNMESNGK YVDRNGNPVT YQTGPIIWGE PGTNGQHAFY QLIHQGTKLI 400
    PCDFIAPAVS HNLVGDHHQK LMSNFFAQTE ALAFGKSAQA VQAELEKAGK 450
    SAAEIAALVP FKVFEGNRPT NSILVKQITP RTLGNLIAMY EHKIFVQGVI 500
    WNIFSFDQWG VELGKQLANQ ILPELADSAA VTSHDSSTNG LINAFKAFRA 550
    Length:550
    Mass (Da):60,691
    Last modified:October 1, 2000 - v1
    Checksum:i5E38B0421C3A1B16
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF93547.1.
    PIRiB82330.
    RefSeqiNP_230028.1. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF93547; AAF93547; VC_0374.
    GeneIDi2615017.
    KEGGivch:VC0374.
    PATRICi20079819. VBIVibCho83274_0350.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF93547.1 .
    PIRi B82330.
    RefSeqi NP_230028.1. NC_002505.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3HJB X-ray 1.50 A/B/C/D 1-550 [» ]
    ProteinModelPortali Q9KUY4.
    SMRi Q9KUY4. Positions 8-549.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC0374.

    Protocols and materials databases

    DNASUi 2615017.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF93547 ; AAF93547 ; VC_0374 .
    GeneIDi 2615017.
    KEGGi vch:VC0374.
    PATRICi 20079819. VBIVibCho83274_0350.

    Phylogenomic databases

    eggNOGi COG0166.
    KOi K01810.
    OMAi NCHFVAN.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .
    BioCyci VCHO:VC0374-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9KUY4.

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiG6PI_VIBCH
    AccessioniPrimary (citable) accession number: Q9KUY4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3