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Q9KUY4

- G6PI_VIBCH

UniProt

Q9KUY4 - G6PI_VIBCH

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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei356 – 3561Proton donorBy similarity
Active sitei387 – 3871By similarity
Active sitei515 – 5151By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: TIGR

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciVCHO:VC0374-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:VC_0374
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Glucose-6-phosphate isomerasePRO_0000180762Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC0374.

Structurei

Secondary structure

1
550
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 93Combined sources
Helixi11 – 2313Combined sources
Helixi28 – 336Combined sources
Helixi38 – 414Combined sources
Beta strandi43 – 464Combined sources
Turni47 – 493Combined sources
Beta strandi50 – 534Combined sources
Beta strandi56 – 583Combined sources
Helixi61 – 7313Combined sources
Helixi76 – 8510Combined sources
Turni91 – 944Combined sources
Helixi99 – 1024Combined sources
Beta strandi115 – 1173Combined sources
Helixi118 – 13720Combined sources
Beta strandi150 – 1545Combined sources
Helixi157 – 1593Combined sources
Helixi161 – 1699Combined sources
Helixi171 – 1733Combined sources
Beta strandi178 – 1825Combined sources
Helixi187 – 1948Combined sources
Helixi199 – 2013Combined sources
Beta strandi202 – 2076Combined sources
Beta strandi209 – 2113Combined sources
Helixi214 – 23118Combined sources
Helixi234 – 2396Combined sources
Beta strandi241 – 2466Combined sources
Helixi248 – 2547Combined sources
Helixi258 – 2603Combined sources
Helixi270 – 2723Combined sources
Turni274 – 2763Combined sources
Helixi277 – 2793Combined sources
Helixi280 – 2867Combined sources
Helixi288 – 30720Combined sources
Helixi310 – 3123Combined sources
Helixi314 – 32714Combined sources
Beta strandi333 – 3397Combined sources
Helixi341 – 3433Combined sources
Helixi346 – 35813Combined sources
Beta strandi376 – 3783Combined sources
Turni382 – 3854Combined sources
Helixi386 – 39510Combined sources
Beta strandi396 – 3983Combined sources
Beta strandi402 – 4098Combined sources
Helixi417 – 43418Combined sources
Helixi438 – 44710Combined sources
Helixi452 – 46211Combined sources
Beta strandi470 – 4767Combined sources
Helixi480 – 50021Combined sources
Helixi509 – 5113Combined sources
Helixi512 – 52110Combined sources
Helixi522 – 5254Combined sources
Beta strandi526 – 5283Combined sources
Helixi536 – 54914Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HJBX-ray1.50A/B/C/D1-550[»]
ProteinModelPortaliQ9KUY4.
SMRiQ9KUY4. Positions 8-549.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9KUY4.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
KOiK01810.
OMAiNCHFVAN.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KUY4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKNINPTQT QAWKALTAHF ESAQDMDLKA LFAQDSERFA KYSARFGQDI
60 70 80 90 100
LVDYSKNLVN AETMQHLFAL AKETDLQSAI TAMFKGEAIN QTEDRAVLHT
110 120 130 140 150
ALRNRSNSPV LVNGEDVMPA VNAVLAKMKA FSERVIGGEW KGFTGKAITD
160 170 180 190 200
VVNIGIGGSD LGPYMVTEAL VPYKNHLTMH FVSNVDGTHM AETLKNVDPE
210 220 230 240 250
TTLFLVASKT FTTQETMTNA HTARDWFLKA AGDEAHVAKH FAALSTNGKA
260 270 280 290 300
VAEFGIDTDN MFEFWDWVGG RYSLWSAIGL SIILSIGYDN FVELLAGAHE
310 320 330 340 350
MDQHFVNTPF ESNIPVILAL IGIWYNNFHG AESEAILPYD QYLHRFAAYF
360 370 380 390 400
QQGNMESNGK YVDRNGNPVT YQTGPIIWGE PGTNGQHAFY QLIHQGTKLI
410 420 430 440 450
PCDFIAPAVS HNLVGDHHQK LMSNFFAQTE ALAFGKSAQA VQAELEKAGK
460 470 480 490 500
SAAEIAALVP FKVFEGNRPT NSILVKQITP RTLGNLIAMY EHKIFVQGVI
510 520 530 540 550
WNIFSFDQWG VELGKQLANQ ILPELADSAA VTSHDSSTNG LINAFKAFRA
Length:550
Mass (Da):60,691
Last modified:October 1, 2000 - v1
Checksum:i5E38B0421C3A1B16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF93547.1.
PIRiB82330.
RefSeqiNP_230028.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF93547; AAF93547; VC_0374.
GeneIDi2615017.
KEGGivch:VC0374.
PATRICi20079819. VBIVibCho83274_0350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF93547.1 .
PIRi B82330.
RefSeqi NP_230028.1. NC_002505.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3HJB X-ray 1.50 A/B/C/D 1-550 [» ]
ProteinModelPortali Q9KUY4.
SMRi Q9KUY4. Positions 8-549.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC0374.

Protocols and materials databases

DNASUi 2615017.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF93547 ; AAF93547 ; VC_0374 .
GeneIDi 2615017.
KEGGi vch:VC0374.
PATRICi 20079819. VBIVibCho83274_0350.

Phylogenomic databases

eggNOGi COG0166.
KOi K01810.
OMAi NCHFVAN.
OrthoDBi EOG64R61J.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .
BioCyci VCHO:VC0374-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9KUY4.

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiG6PI_VIBCH
AccessioniPrimary (citable) accession number: Q9KUY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3