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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei356Proton donorBy similarity1
Active sitei387By similarity1
Active sitei515By similarity1

GO - Molecular functioni

  • glucose-6-phosphate isomerase activity Source: TIGR

GO - Biological processi

  • gluconeogenesis Source: UniProtKB-HAMAP
  • glycolytic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciVCHO:VC0374-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:VC_0374
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001807621 – 550Glucose-6-phosphate isomeraseAdd BLAST550

Interactioni

Protein-protein interaction databases

STRINGi243277.VC0374.

Structurei

Secondary structure

1550
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 9Combined sources3
Helixi11 – 23Combined sources13
Helixi28 – 33Combined sources6
Helixi38 – 41Combined sources4
Beta strandi43 – 46Combined sources4
Turni47 – 49Combined sources3
Beta strandi50 – 53Combined sources4
Beta strandi56 – 58Combined sources3
Helixi61 – 73Combined sources13
Helixi76 – 85Combined sources10
Turni91 – 94Combined sources4
Helixi99 – 102Combined sources4
Beta strandi115 – 117Combined sources3
Helixi118 – 137Combined sources20
Beta strandi150 – 154Combined sources5
Helixi157 – 159Combined sources3
Helixi161 – 169Combined sources9
Helixi171 – 173Combined sources3
Beta strandi178 – 182Combined sources5
Helixi187 – 194Combined sources8
Helixi199 – 201Combined sources3
Beta strandi202 – 207Combined sources6
Beta strandi209 – 211Combined sources3
Helixi214 – 231Combined sources18
Helixi234 – 239Combined sources6
Beta strandi241 – 246Combined sources6
Helixi248 – 254Combined sources7
Helixi258 – 260Combined sources3
Helixi270 – 272Combined sources3
Turni274 – 276Combined sources3
Helixi277 – 279Combined sources3
Helixi280 – 286Combined sources7
Helixi288 – 307Combined sources20
Helixi310 – 312Combined sources3
Helixi314 – 327Combined sources14
Beta strandi333 – 339Combined sources7
Helixi341 – 343Combined sources3
Helixi346 – 358Combined sources13
Beta strandi376 – 378Combined sources3
Turni382 – 385Combined sources4
Helixi386 – 395Combined sources10
Beta strandi396 – 398Combined sources3
Beta strandi402 – 409Combined sources8
Helixi417 – 434Combined sources18
Helixi438 – 447Combined sources10
Helixi452 – 462Combined sources11
Beta strandi470 – 476Combined sources7
Helixi480 – 500Combined sources21
Helixi509 – 511Combined sources3
Helixi512 – 521Combined sources10
Helixi522 – 525Combined sources4
Beta strandi526 – 528Combined sources3
Helixi536 – 549Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HJBX-ray1.50A/B/C/D1-550[»]
ProteinModelPortaliQ9KUY4.
SMRiQ9KUY4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9KUY4.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiENOG4107QP8. Bacteria.
COG0166. LUCA.
KOiK01810.
OMAiSHLIAPY.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KUY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKNINPTQT QAWKALTAHF ESAQDMDLKA LFAQDSERFA KYSARFGQDI
60 70 80 90 100
LVDYSKNLVN AETMQHLFAL AKETDLQSAI TAMFKGEAIN QTEDRAVLHT
110 120 130 140 150
ALRNRSNSPV LVNGEDVMPA VNAVLAKMKA FSERVIGGEW KGFTGKAITD
160 170 180 190 200
VVNIGIGGSD LGPYMVTEAL VPYKNHLTMH FVSNVDGTHM AETLKNVDPE
210 220 230 240 250
TTLFLVASKT FTTQETMTNA HTARDWFLKA AGDEAHVAKH FAALSTNGKA
260 270 280 290 300
VAEFGIDTDN MFEFWDWVGG RYSLWSAIGL SIILSIGYDN FVELLAGAHE
310 320 330 340 350
MDQHFVNTPF ESNIPVILAL IGIWYNNFHG AESEAILPYD QYLHRFAAYF
360 370 380 390 400
QQGNMESNGK YVDRNGNPVT YQTGPIIWGE PGTNGQHAFY QLIHQGTKLI
410 420 430 440 450
PCDFIAPAVS HNLVGDHHQK LMSNFFAQTE ALAFGKSAQA VQAELEKAGK
460 470 480 490 500
SAAEIAALVP FKVFEGNRPT NSILVKQITP RTLGNLIAMY EHKIFVQGVI
510 520 530 540 550
WNIFSFDQWG VELGKQLANQ ILPELADSAA VTSHDSSTNG LINAFKAFRA
Length:550
Mass (Da):60,691
Last modified:October 1, 2000 - v1
Checksum:i5E38B0421C3A1B16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF93547.1.
PIRiB82330.
RefSeqiNP_230028.1. NC_002505.1.
WP_000916643.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF93547; AAF93547; VC_0374.
GeneIDi2615017.
KEGGivch:VC0374.
PATRICi20079819. VBIVibCho83274_0350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF93547.1.
PIRiB82330.
RefSeqiNP_230028.1. NC_002505.1.
WP_000916643.1. NC_002505.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HJBX-ray1.50A/B/C/D1-550[»]
ProteinModelPortaliQ9KUY4.
SMRiQ9KUY4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC0374.

Protocols and materials databases

DNASUi2615017.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF93547; AAF93547; VC_0374.
GeneIDi2615017.
KEGGivch:VC0374.
PATRICi20079819. VBIVibCho83274_0350.

Phylogenomic databases

eggNOGiENOG4107QP8. Bacteria.
COG0166. LUCA.
KOiK01810.
OMAiSHLIAPY.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciVCHO:VC0374-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9KUY4.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PI_VIBCH
AccessioniPrimary (citable) accession number: Q9KUY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.