ID MDH_VIBCH Reviewed; 311 AA. AC Q9KUT3; Q8GN36; Q8GN37; Q8GN38; Q8GN39; Q99PZ5; Q99Q77; Q99QN5; Q9AG49; AC Q9AG50; Q9AIU2; Q9R3N1; Q9R3N2; Q9R3N3; Q9S4R7; Q9XCZ8; DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-2001, sequence version 2. DT 27-MAR-2024, entry version 145. DE RecName: Full=Malate dehydrogenase; DE EC=1.1.1.37; GN Name=mdh; OrderedLocusNames=VC_0432; OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae; OC Vibrio. OX NCBI_TaxID=243277; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=M535, M536, M548, M549, M550, M551, M553, M554, M555, M556, RC M557, M558, M559, M560, M561, M562, M563, M645, and M793; RX PubMed=10024551; DOI=10.1128/iai.67.3.1116-1124.1999; RA Byun R., Elbourne L.D., Lan R., Reeves P.R.; RT "Evolutionary relationships of pathogenic clones of Vibrio cholerae by RT sequence analysis of four housekeeping genes."; RL Infect. Immun. 67:1116-1124(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 39315 / El Tor Inaba N16961; RX PubMed=10952301; DOI=10.1038/35020000; RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A., RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.; RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio RT cholerae."; RL Nature 406:477-483(2000). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-248. RC STRAIN=151 / Serotype O37, 208 / Serotype O11, ATCC 25870 / Classical RC Inaba 569B / Serotype O1, CO130 / Serotype O37, V46 / Serotype O141, RC and V52 / Serotype O37; RX PubMed=10986258; DOI=10.1128/jb.182.19.5530-5538.2000; RA Boyd E.F., Heilpern A.J., Waldor M.K.; RT "Molecular analyses of a putative CTXphi precursor and evidence for RT independent acquisition of distinct CTXphis by toxigenic Vibrio cholerae."; RL J. Bacteriol. 182:5530-5538(2000). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-201. RC STRAIN=25872, 329 / Serotype O139, 653/36 / Serotype O139, BO1 / RC Serotype O139, BO2 / Serotype O139, BO4 / Serotype O139, CO391 / RC Serotype O139, CO396 / Serotype O139, CO402 / Serotype O139, CO403 / RC Serotype O139, CO404 / Serotype O139, CO406 / Serotype O139, CO407 / RC Serotype O139, CO414 / Serotype O139, CO415 / Serotype O139, CO418 / RC Serotype O139, CO487 / Serotype O1, MDO90 / Serotype O139, MOD084 / RC Serotype O139, NPO388 / Serotype O139, NPO390 / Serotype O139, NT329 / RC Serotype O139, NT330 / Serotype O139, NT638 / Serotype O139, NT642 / RC Serotype O139, NT648 / Serotype O139, SG24 / Serotype O139, SO19 / RC Serotype O139, SO29 / Serotype O139, SO30 / Serotype O139, and VO6 / RC Serotype O139; RX PubMed=11844759; DOI=10.1128/jb.184.5.1304-1313.2002; RA Farfan M., Minana-Galbis D., Fuste M.C., Loren J.G.; RT "Allelic diversity and population structure in Vibrio cholerae O139 Bengal RT based on nucleotide sequence analysis."; RL J. Bacteriol. 184:1304-1313(2002). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 111-310. RC STRAIN=GD64313 / Serotype O1, GD9512 / Serotype O139, GD98200 / RC Serotype O139, and GD98224 / Serotype O1; RA Yongyu R., Biao K., Shouyi G.; RT "Housekeeping genes of strains of Vibrio cholerae isolated from Guangdong RT province."; RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the reversible oxidation of malate to oxaloacetate. CC {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate; CC Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589, CC ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.37; CC -!- SUBUNIT: Homodimer. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 1 family. CC {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAF93605.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF117859; AAD23488.1; -; Genomic_DNA. DR EMBL; AF117860; AAD23489.1; -; Genomic_DNA. DR EMBL; AF117861; AAD23490.1; -; Genomic_DNA. DR EMBL; AF117862; AAD23491.1; -; Genomic_DNA. DR EMBL; AF117863; AAD23492.1; -; Genomic_DNA. DR EMBL; AF117864; AAD23493.1; -; Genomic_DNA. DR EMBL; AF117865; AAD23494.1; -; Genomic_DNA. DR EMBL; AF117866; AAD23495.1; -; Genomic_DNA. DR EMBL; AF117867; AAD23496.1; -; Genomic_DNA. DR EMBL; AF117868; AAD23497.1; -; Genomic_DNA. DR EMBL; AF117869; AAD23498.1; -; Genomic_DNA. DR EMBL; AF117870; AAD23499.1; -; Genomic_DNA. DR EMBL; AF117871; AAD23500.1; -; Genomic_DNA. DR EMBL; AF117872; AAD23501.1; -; Genomic_DNA. DR EMBL; AF117873; AAD23502.1; -; Genomic_DNA. DR EMBL; AF117874; AAD23503.1; -; Genomic_DNA. DR EMBL; AF117875; AAD23504.1; -; Genomic_DNA. DR EMBL; AF117876; AAD23505.1; -; Genomic_DNA. DR EMBL; AF117877; AAD23506.1; -; Genomic_DNA. DR EMBL; AE003852; AAF93605.1; ALT_INIT; Genomic_DNA. DR EMBL; AF238329; AAK15054.1; -; Genomic_DNA. DR EMBL; AF238330; AAK15055.1; -; Genomic_DNA. DR EMBL; AF238331; AAK15056.1; -; Genomic_DNA. DR EMBL; AF238332; AAK15057.1; -; Genomic_DNA. DR EMBL; AF238333; AAK15058.1; -; Genomic_DNA. DR EMBL; AF238334; AAK15059.1; -; Genomic_DNA. DR EMBL; AF343280; AAK30532.1; -; Genomic_DNA. DR EMBL; AF343281; AAK30533.1; -; Genomic_DNA. DR EMBL; AF343282; AAK30534.1; -; Genomic_DNA. DR EMBL; AF343283; AAK30535.1; -; Genomic_DNA. DR EMBL; AF343284; AAK30536.1; -; Genomic_DNA. DR EMBL; AF343285; AAK30537.1; -; Genomic_DNA. DR EMBL; AF343286; AAK30538.1; -; Genomic_DNA. DR EMBL; AF343287; AAK30539.1; -; Genomic_DNA. DR EMBL; AF343288; AAK30540.1; -; Genomic_DNA. DR EMBL; AF343289; AAK30541.1; -; Genomic_DNA. DR EMBL; AF343290; AAK30542.1; -; Genomic_DNA. DR EMBL; AF343291; AAK30543.1; -; Genomic_DNA. DR EMBL; AF343292; AAK30544.1; -; Genomic_DNA. DR EMBL; AF343293; AAK30545.1; -; Genomic_DNA. DR EMBL; AF343294; AAK30546.1; -; Genomic_DNA. DR EMBL; AF343295; AAK30547.1; -; Genomic_DNA. DR EMBL; AF343296; AAK30548.1; -; Genomic_DNA. DR EMBL; AF343297; AAK30549.1; -; Genomic_DNA. DR EMBL; AF343298; AAK30550.1; -; Genomic_DNA. DR EMBL; AF343299; AAK30551.1; -; Genomic_DNA. DR EMBL; AF343300; AAK30552.1; -; Genomic_DNA. DR EMBL; AF343301; AAK30553.1; -; Genomic_DNA. DR EMBL; AF343302; AAK30554.1; -; Genomic_DNA. DR EMBL; AF343303; AAK30555.1; -; Genomic_DNA. DR EMBL; AF343304; AAK30556.1; -; Genomic_DNA. DR EMBL; AF343305; AAK30557.1; -; Genomic_DNA. DR EMBL; AF343306; AAK30558.1; -; Genomic_DNA. DR EMBL; AF343307; AAK30559.1; -; Genomic_DNA. DR EMBL; AF343308; AAK30560.1; -; Genomic_DNA. DR EMBL; AF343309; AAK30561.1; -; Genomic_DNA. DR EMBL; AF343310; AAK30562.1; -; Genomic_DNA. DR EMBL; AF540657; AAN23136.1; -; Genomic_DNA. DR EMBL; AF540658; AAN23137.1; -; Genomic_DNA. DR EMBL; AF540659; AAN23138.1; -; Genomic_DNA. DR EMBL; AF540660; AAN23139.1; -; Genomic_DNA. DR PIR; G82324; G82324. DR RefSeq; NP_230086.2; NC_002505.1. DR RefSeq; WP_000861563.1; NZ_LT906614.1. DR AlphaFoldDB; Q9KUT3; -. DR SMR; Q9KUT3; -. DR STRING; 243277.VC_0432; -. DR DNASU; 2615693; -. DR EnsemblBacteria; AAF93605; AAF93605; VC_0432. DR GeneID; 69720808; -. DR KEGG; vch:VC_0432; -. DR PATRIC; fig|243277.26.peg.406; -. DR eggNOG; COG0039; Bacteria. DR HOGENOM; CLU_047181_1_0_6; -. DR Proteomes; UP000000584; Chromosome 1. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0030060; F:L-malate dehydrogenase activity; IBA:GO_Central. DR GO; GO:0006108; P:malate metabolic process; IEA:InterPro. DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule. DR CDD; cd01337; MDH_glyoxysomal_mitochondrial; 1. DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1. DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1. DR HAMAP; MF_01516; Malate_dehydrog_1; 1. DR InterPro; IPR001557; L-lactate/malate_DH. DR InterPro; IPR022383; Lactate/malate_DH_C. DR InterPro; IPR001236; Lactate/malate_DH_N. DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C. DR InterPro; IPR001252; Malate_DH_AS. DR InterPro; IPR010097; Malate_DH_type1. DR InterPro; IPR023958; Malate_DH_type1_bac. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR NCBIfam; TIGR01772; MDH_euk_gproteo; 1. DR PANTHER; PTHR11540; MALATE AND LACTATE DEHYDROGENASE; 1. DR PANTHER; PTHR11540:SF16; MALATE DEHYDROGENASE, MITOCHONDRIAL; 1. DR Pfam; PF02866; Ldh_1_C; 1. DR Pfam; PF00056; Ldh_1_N; 1. DR PIRSF; PIRSF000102; Lac_mal_DH; 1. DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1. DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1. DR PROSITE; PS00068; MDH; 1. PE 3: Inferred from homology; KW NAD; Oxidoreductase; Reference proteome; Tricarboxylic acid cycle. FT CHAIN 1..311 FT /note="Malate dehydrogenase" FT /id="PRO_0000113328" FT ACT_SITE 177 FT /note="Proton acceptor" FT /evidence="ECO:0000250" FT BINDING 7..13 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0000250" FT BINDING 34 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0000250" FT BINDING 81 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 87 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 94 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0000250" FT BINDING 117..119 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0000250" FT BINDING 119 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 153 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 227 FT /ligand="NAD(+)" FT /ligand_id="ChEBI:CHEBI:57540" FT /evidence="ECO:0000250" FT VARIANT 63 FT /note="P -> T (in strain: M551)" FT VARIANT 171 FT /note="V -> L (in strain: M553, M535, CO391, CO407 and FT 653/36)" FT VARIANT 204 FT /note="K -> N (in strain: M548)" FT VARIANT 223 FT /note="A -> T (in strain: 569B)" FT VARIANT 277 FT /note="A -> E (in strain: M550, M551, M554, M557, M558 and FT GD98200)" SQ SEQUENCE 311 AA; 32015 MW; 5AD037C0E548BE9C CRC64; MKVAVIGAAG GIGQALALLL KNRLPAGSDL ALYDIAPVTP GVAADLSHIP TPVTIKGYAG EDPTPALEGA DVVLVSAGVA RKPGMDRADL FNVNAGIVKA LAEKIAVVCP KACVGIITNP VNTTVPIAAE VLKKAGVYDK RKLFGVTTLD VIRSETFVAA LKDKDPGQVR VPVIGGHSGV TILPLLSQVE GVSFTDEEVA ALTKRIQNAG TEVVEAKAGG GSATLSMGQA ACRFGLALVK ALQGESDVVE YAYVEGEGEY APFFAQPIKL GKNGVEALLD IGKLSAYEQA ALDGMLDTLK GDIQIGVEFV K //