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Protein

Malate dehydrogenase

Gene

mdh

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADBy similarity1
Binding sitei81SubstrateBy similarity1
Binding sitei87SubstrateBy similarity1
Binding sitei94NADBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei153SubstrateBy similarity1
Active sitei177Proton acceptorBy similarity1
Binding sitei227NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 13NADBy similarity7
Nucleotide bindingi117 – 119NADBy similarity3

GO - Molecular functioni

  • L-malate dehydrogenase activity Source: UniProtKB-EC
  • malic enzyme activity Source: TIGR

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • malate metabolic process Source: InterPro
  • tricarboxylic acid cycle Source: TIGR

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:VC_0432
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001133281 – 311Malate dehydrogenaseAdd BLAST311

Proteomic databases

PRIDEiQ9KUT3

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi243277.VC0432

Structurei

3D structure databases

ProteinModelPortaliQ9KUT3
SMRiQ9KUT3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
KOiK00024
OMAiQCTPKVE

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_01516 Malate_dehydrog_1, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010097 Malate_DH_type1
IPR023958 Malate_DH_type1_bac
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR11540:SF22 PTHR11540:SF22, 1 hit
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01772 MDH_euk_gproteo, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KUT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVAVIGAAG GIGQALALLL KNRLPAGSDL ALYDIAPVTP GVAADLSHIP
60 70 80 90 100
TPVTIKGYAG EDPTPALEGA DVVLVSAGVA RKPGMDRADL FNVNAGIVKA
110 120 130 140 150
LAEKIAVVCP KACVGIITNP VNTTVPIAAE VLKKAGVYDK RKLFGVTTLD
160 170 180 190 200
VIRSETFVAA LKDKDPGQVR VPVIGGHSGV TILPLLSQVE GVSFTDEEVA
210 220 230 240 250
ALTKRIQNAG TEVVEAKAGG GSATLSMGQA ACRFGLALVK ALQGESDVVE
260 270 280 290 300
YAYVEGEGEY APFFAQPIKL GKNGVEALLD IGKLSAYEQA ALDGMLDTLK
310
GDIQIGVEFV K
Length:311
Mass (Da):32,015
Last modified:June 1, 2001 - v2
Checksum:i5AD037C0E548BE9C
GO

Sequence cautioni

The sequence AAF93605 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti63P → T in strain: M551. 1
Natural varianti171V → L in strain: M553, M535, CO391, CO407 and 653/36. 1
Natural varianti204K → N in strain: M548. 1
Natural varianti223A → T in strain: 569B. 1
Natural varianti277A → E in strain: M550, M551, M554, M557, M558 and GD98200. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117859 Genomic DNA Translation: AAD23488.1
AF117860 Genomic DNA Translation: AAD23489.1
AF117861 Genomic DNA Translation: AAD23490.1
AF117862 Genomic DNA Translation: AAD23491.1
AF117863 Genomic DNA Translation: AAD23492.1
AF117864 Genomic DNA Translation: AAD23493.1
AF117865 Genomic DNA Translation: AAD23494.1
AF117866 Genomic DNA Translation: AAD23495.1
AF117867 Genomic DNA Translation: AAD23496.1
AF117868 Genomic DNA Translation: AAD23497.1
AF117869 Genomic DNA Translation: AAD23498.1
AF117870 Genomic DNA Translation: AAD23499.1
AF117871 Genomic DNA Translation: AAD23500.1
AF117872 Genomic DNA Translation: AAD23501.1
AF117873 Genomic DNA Translation: AAD23502.1
AF117874 Genomic DNA Translation: AAD23503.1
AF117875 Genomic DNA Translation: AAD23504.1
AF117876 Genomic DNA Translation: AAD23505.1
AF117877 Genomic DNA Translation: AAD23506.1
AE003852 Genomic DNA Translation: AAF93605.1 Different initiation.
AF238329 Genomic DNA Translation: AAK15054.1
AF238330 Genomic DNA Translation: AAK15055.1
AF238331 Genomic DNA Translation: AAK15056.1
AF238332 Genomic DNA Translation: AAK15057.1
AF238333 Genomic DNA Translation: AAK15058.1
AF238334 Genomic DNA Translation: AAK15059.1
AF343280 Genomic DNA Translation: AAK30532.1
AF343281 Genomic DNA Translation: AAK30533.1
AF343282 Genomic DNA Translation: AAK30534.1
AF343283 Genomic DNA Translation: AAK30535.1
AF343284 Genomic DNA Translation: AAK30536.1
AF343285 Genomic DNA Translation: AAK30537.1
AF343286 Genomic DNA Translation: AAK30538.1
AF343287 Genomic DNA Translation: AAK30539.1
AF343288 Genomic DNA Translation: AAK30540.1
AF343289 Genomic DNA Translation: AAK30541.1
AF343290 Genomic DNA Translation: AAK30542.1
AF343291 Genomic DNA Translation: AAK30543.1
AF343292 Genomic DNA Translation: AAK30544.1
AF343293 Genomic DNA Translation: AAK30545.1
AF343294 Genomic DNA Translation: AAK30546.1
AF343295 Genomic DNA Translation: AAK30547.1
AF343296 Genomic DNA Translation: AAK30548.1
AF343297 Genomic DNA Translation: AAK30549.1
AF343298 Genomic DNA Translation: AAK30550.1
AF343299 Genomic DNA Translation: AAK30551.1
AF343300 Genomic DNA Translation: AAK30552.1
AF343301 Genomic DNA Translation: AAK30553.1
AF343302 Genomic DNA Translation: AAK30554.1
AF343303 Genomic DNA Translation: AAK30555.1
AF343304 Genomic DNA Translation: AAK30556.1
AF343305 Genomic DNA Translation: AAK30557.1
AF343306 Genomic DNA Translation: AAK30558.1
AF343307 Genomic DNA Translation: AAK30559.1
AF343308 Genomic DNA Translation: AAK30560.1
AF343309 Genomic DNA Translation: AAK30561.1
AF343310 Genomic DNA Translation: AAK30562.1
AF540657 Genomic DNA Translation: AAN23136.1
AF540658 Genomic DNA Translation: AAN23137.1
AF540659 Genomic DNA Translation: AAN23138.1
AF540660 Genomic DNA Translation: AAN23139.1
PIRiG82324
RefSeqiNP_230086.2, NC_002505.1
WP_000861563.1, NC_002505.1

Genome annotation databases

EnsemblBacteriaiAAF93605; AAF93605; VC_0432
GeneIDi2615693
KEGGivch:VC0432
PATRICifig|243277.26.peg.406

Similar proteinsi

Entry informationi

Entry nameiMDH_VIBCH
AccessioniPrimary (citable) accession number: Q9KUT3
Secondary accession number(s): Q8GN36
, Q8GN37, Q8GN38, Q8GN39, Q99PZ5, Q99Q77, Q99QN5, Q9AG49, Q9AG50, Q9AIU2, Q9R3N1, Q9R3N2, Q9R3N3, Q9S4R7, Q9XCZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health